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Expression of basic transcription regulatory element binding protein 2 (BTEB2) in human cerebral aneurysms

Research Project

Project/Area Number 13671439
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionThe University of Tokushima

Principal Investigator

NAKAJIMA Norito  The University of Tokushima, School of Medicine, Assistant, 医学部附属病院, 助手 (00332817)

Co-Investigator(Kenkyū-buntansha) ISATOH Koichi  The University of Tokushima, School of Medicine, Assistant Professor, 医学部附属病院, 講師 (90225938)
SANO Toshiaki  The University of Tokushima, School of Medicine, Professor, 医学部, 教授 (80154128)
NAGAHIRO Shinji  The University of Tokushima, School of Medicine, Professor, 医学部, 教授 (60145315)
松原 俊二  徳島大学, 医学部, 助手 (60294675)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordscerebral aneurysm / smooth muscle cell / macrophage / BTEB2 / 脳動脈癌
Research Abstract

Introduction: Smemb, which is known increase in synthetic smooth muscle cells (SMCs). The induction of the gene for Smemb is regulated by basic transcription regulatory element binding protein 2 (BTEB2). In the current study we investigated the expression of BTEB2 in the aneurysm to determine its role in aneurysmail development and in protection against wall rupture.
Methods: Non-ruptured aneurysms (n=15) and ruptured aneurysms (n=12) were obtained at surgery or autopsy. Five control arteries were obtained at autopsy. The spesimens were stained immunohistochemically with antibodies to a-smooth muscle actin, macrophages and BTEB2.
Results: In control cerebral arteries, SMCs in the media and macrophages in the adventitia were negative for BTEB2. In 7 of 9 non-ruptured aneurysms larger than 10 mm, but not in any of the small non-ruptured aneurysms, macrophages and SMCs in the luminal layer were positive for BTEB2. And in thrombus of non-ruptured giant aneurysms, SMCs migrated and macrophages were strongly positive for BTEB2. With the exception of a few large or giant aneurysms, in ruptured aneurysms, macrophages and SMCs in the luminal layer were negative for BTEB2.
Conclusion: In our study, BTEB2-positive macrophages and SMCs were present in the luminal layer of larger and giant non-ruptured aneurysms. This suggests that BTEB2 expression in the aneurysmal wall is related to aneurismal growth and may against rupture.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 永廣信治: "部分血栓化巨大動脈癌の増大機序と治療"Jpn J Neurosurg. 10. 10-17 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 佐藤浩一: "老年脳神経外科の最前線 未破裂脳動脈瘤"CLINlCAL NEUROSCIENCE. 19. 999-1002 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Matsubara: "Guiglielmi detachable coid emboliation for ruptured lower-midbasilar trunk aneurysms-a report of five cases-"Neuroradiology. 43. 884-890 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Satoh: "Cerebellar hemorrhage caused by dural arteriovenous fistula : a review of five cases"Journal of Neurosurgery. 94. 422-426 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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