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Roles of reactive glial cells after brain injury

Research Project

Project/Area Number 13671448
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOITA MEDICAL UNIVERSITY

Principal Investigator

ISONO Mitsuo  Oita University, School of Medicine, Assistant Professor, 医学部, 助教授 (60151437)

Co-Investigator(Kenkyū-buntansha) KAMIDA Tohru  Oita University, School of Medicine, Associate Professor, 医学部, 講師 (90315333)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsTGF / astrocyte / microglia / BrDU / TGF2 / astrogliosis / IL-6
Research Abstract

To determine the exact role of TGF-α in glial activation after traumatic brain injury, we investigated the astroglial and microglial responses after cortical stab wound injury in TGF-α overexpressing mice. Adult male B6D2-TgN (MMTVTGFA) 29RjC transgenic mice were used for the subjects. This transgenic line carries a TGF-alpha cDNA under the control of the dexamethasone-inducible MMTV promoter. Thus, exogenous administration of dexamethasone induces TGF-α overexpression. Male B6D2F1/J mice at the same age served as wild-type animals. After the cortical stab wound injury, expression of glial fibrilary acidic protein, CD-11b and interleukine-6 were investigated immunohistochemically. The results indicate that TGF-α might affect astrocytic hypertrophy without affecting microgliosis not only in the normal condition, but also in the pathological condition. Moreover, overexpression of TGF-α induced obvious expression of IL-6 around the lesion. This fact might indicate possible role of TGF-α in affecting neuronal function.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Isono M, Goda M, et al.: "TGF-alpha overexpression induces astrocytic hypertrophy after cortical stab wound injury"Neurological Research. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Isono M, Goda M, Kobayashi H, Wu LJI: "TGF-alpha overexpression induces astrocytic hypertrophy after cortical stab wound injury"Neurological Research. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary

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Published: 2001-04-01   Modified: 2016-04-21  

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