| Project/Area Number |
13671450
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
SIMOZURU Tetsuro Kagoshima University, University Hospital Faculty of medicine, Assistant Professor, 医学部附属病院, 講師 (20284870)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AKASHI Mitsuru Kagoshima University, Graduate School of Science and Engineering, Professor, 大学院・理工学研究科, 教授 (20145460)
NIIRO Masaki Kagoshima University, Faculty of medicine, Assistant Professor, 医学部, 助教授 (30172612)
KURATSU Jun-ichi Kagoshima University, Faculty of medicine, Professor, 医学部, 教授 (20145296)
KISHIDA Akio Department of Bioengineering, National Cardio-Vascular Center Research Institute, Director, 生体工学部, 部長 (60224929)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
|
|---|
| Keywords | Experimental aneurysm / Embolization / Hydroxyapatite / bFGF / GDC / aneurysm |
|---|
| Research Abstract |
Aneurysmal embolization are clinically adapted as a useful alternative of the direct surgery. However, an incomplete occlusion in wide-necked, large aneurysms, remains to be unsolved.
We produced the coating of hydroxyapatite (HAp) and fibroblast growth factor-basic (bFGF) on Guglielmi detachable coils (GDCs), and check the development of coated coils on endotherialization across the orifice.
A total of 18 aneurysms were experimentally made in the common cartoid arteries of swine using microsurgical technique. Embolization was done on these aneurysms using standard GDCs and coated GDCs with HAp (GDC-HAp) and with bFGF (GDC-HAp-bFGF). The animals were then killed 14 days after embolization. The development of tissue scarring and coverage the aneurysm's orifice were evaluated macroscopically. No significant difference of volume ratio of the coils exited in each groups. Macroscopically, covering ratio of fibrous membrane at the neck of aneurysms were 88.3% in a group with GDC-HAp-bFGF, while it were 26.7% in a group with standard GDC and it was 41.7% in a group with GDC-HAp.
These results indicated that coating by hydroxyapatite and bFGF might facilitate a wound healing in an experimental aneurysm model.
|
