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Hydroxyapatite and bFGF Coating of Detachable Coils for Endovascular Occlusion of Experimental Aneurysm

Research Project

Project/Area Number 13671450
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKagoshima University

Principal Investigator

SIMOZURU Tetsuro  Kagoshima University, University Hospital Faculty of medicine, Assistant Professor, 医学部附属病院, 講師 (20284870)

Co-Investigator(Kenkyū-buntansha) AKASHI Mitsuru  Kagoshima University, Graduate School of Science and Engineering, Professor, 大学院・理工学研究科, 教授 (20145460)
NIIRO Masaki  Kagoshima University, Faculty of medicine, Assistant Professor, 医学部, 助教授 (30172612)
KURATSU Jun-ichi  Kagoshima University, Faculty of medicine, Professor, 医学部, 教授 (20145296)
KISHIDA Akio  Department of Bioengineering, National Cardio-Vascular Center Research Institute, Director, 生体工学部, 部長 (60224929)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsExperimental aneurysm / Embolization / Hydroxyapatite / bFGF / GDC / aneurysm
Research Abstract

Aneurysmal embolization are clinically adapted as a useful alternative of the direct surgery. However, an incomplete occlusion in wide-necked, large aneurysms, remains to be unsolved.
We produced the coating of hydroxyapatite (HAp) and fibroblast growth factor-basic (bFGF) on Guglielmi detachable coils (GDCs), and check the development of coated coils on endotherialization across the orifice.
A total of 18 aneurysms were experimentally made in the common cartoid arteries of swine using microsurgical technique. Embolization was done on these aneurysms using standard GDCs and coated GDCs with HAp (GDC-HAp) and with bFGF (GDC-HAp-bFGF). The animals were then killed 14 days after embolization. The development of tissue scarring and coverage the aneurysm's orifice were evaluated macroscopically. No significant difference of volume ratio of the coils exited in each groups. Macroscopically, covering ratio of fibrous membrane at the neck of aneurysms were 88.3% in a group with GDC-HAp-bFGF, while it were 26.7% in a group with standard GDC and it was 41.7% in a group with GDC-HAp.
These results indicated that coating by hydroxyapatite and bFGF might facilitate a wound healing in an experimental aneurysm model.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Shimozuru T, Kamezawa T, Kurats J: "Hydroxyapatite coating of detachable coils for endovascular occlusion of experimental aneurysm"Interventional neruoradiology. 7(Suppl 1). 105-110 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimozuru T, Kamezawa T, Kuratsu J: "Hydroxyapatite & bFGF coating of detachable coils for endovascular occlusion of experimental aneurysm"Interventional neuroradiology. 9(suppl 1). 29-33 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsusaki M, Kamezawa T, Shimozuru T: "Novel Guglielmi detachable coils (GDCs) for the treatment of brain aneurysms. In vitro study of hydroxyapatite coating on Pt plate as GDCs model"Journal of Biomedical Materials Research. Jul.15 66B(1). 429-438 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimozuru T, Kamezawa T, Kuratsu J, et al.: "Hydroxyapatite coating of detachable coils for endovascular occlusion of experimental aneurysm"Interventional neuroradiology. 7 (Suppl 1). 105-110 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimozuru T, Kamezawa T, Kuratsu J, et al.: "Hydroxyapatite & bFGF coating of detachable coils for endovascular occlusion of experimental aneurysm"Interventional neuroradiology. 9 (Suppl 1). 29-33 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsusaki M, Kamezawa T, Shimozuru T, et al.: "Novel Guglielmi detachable coils (GDCs) for the treatment of brain aneurysms. In vitro study of hydroxyapatite coating on Pt plate as GDCs model"Journal of Biomedical Materials Research. 66B(1). 429-438 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimozuru T, Kamezawa T, Kuratsu J: "Hydroxyapatite coating of detachable coils for endovascular occlusion of experimental aneurysm"Interventional neuroradiology. 7(Suppl 1). 105-110 (2001)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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