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Analysis of the neural circuit related to sensory discrimination based on multi-dipole estimation with high temporal resolution

Research Project

Project/Area Number 13671452
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTokyo Metropolitan University of Health Sciences

Principal Investigator

KIKUCHI Yoshiaki  Tokyo Metropolitan University of Health Sciences, Professor, 保健科学部, 教授 (50134739)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsmagnetoencephalography (MEG) / multi-dipole / hippocampus / P3 / working memory / 弁別処理機構
Research Abstract

Although new imaging methods for measuring regional cerebral blood flow and metabolism such as PET and fMRI provide a detailed anatomical picture of the brain regions that are active during an sensory discrimination process, these methods fail to reveal the time course of the active regions with sufficiently high temporal resolution. On the other hand, the time course of brain activity patterns can be measured at the millisecond level of resolution through recordings of the neuromagnetic fields that are generated by active populations of nerve cells. Furthermore, recently developed whole-cortex MEG systems enabled us to measure all the brain areas at a time, without repositioning to record each area. The purpose of the present study was to construct the system for semi-automatically estimating multiple dipoles with sufficiently high temporal resolution. Furthermore, the temporal structure of the neural activity related to sensory discrimination was investigated by using the analyzing s … More ystem.
The algorithm for multi-dipole estimation is based on the following three basic points: 1) In selection of the pair of the inward maximum and the outward maximum, the most neighboring pair in one hemisphere is to be selected as the first step for estimation. 2) Estimation errors are less than 10%, 15% and 20% for 4, 3 and 2 dipoles respectively. 3) Multi-dipole estimation is carried out based on spatio-temporal continuity and stability of the neuronal activities.
By using the system, the following neuronal activities were observed related to sensory discrimination: 1) activity in its modality-specific area. 2) the areas related to attention such as prefrontal area, cingulate gyrus, and so on. 3) the areas related to memory such as dorsolateral prefrontal cortex, hippocampus, parietal association cortex and temporal association cortex. These activities were estimated following the above order during the beginning, and in parallel after. These brain areas may construct the working memory system required for sensory discrimination. Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y., et al.: "Rule discovery from fMRI brain images by logical regression analysis"Progress in Discovery Science, Springer-Verlag Berlin, Heidelberg, New York. 232-245 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 畠山英子, 石川宣子, 菊池吉晃, 他: "生命科学を基礎とする感性と食環境ならびに音・音楽環境の相関に関する研究"東北福祉大学感性福祉研究所研究報告書. 62-65 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 大渕 新, 乳井嘉之, 篠原広行, 菊池吉晃: "MRI2次元フーリエ変換法における位相エンコード数と再構成像の関係"第8回東京保健科学学会学術集会抄録集. 34 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 大渕 新, 乳井嘉之, 篠原広行, 菊池吉晃: "MRIスピンエコー法の計算機シミュレーション"第8回東京保健科学学会学術集会抄録集. 35 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 栃木捷一郎, 渡邉 修, 木下正信, 菊池吉晃, 笠井久隆, 米本恭三: "片側性大脳半球血管障害例における定量的脳幹誘発電筋電図所見"第40回日本リハビリテーション医学会学術集会. (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kikuchi, Y., Tanaka, M., Nishimura, C., Yoshizawa, S.: "Sensory discrimination mechanism by multi-dipole estimation with high temporal resolution"The transaction of IEEJ (The Institute of Electrical Engineers of Japan). IM-01-55. 5-9 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kikuchi, Y., Yonemoto, K.: "Temporal structure of the brain activities related to left-right hand discrimination"Japanese Journal of rehabilitation medicine. 38: supplement. S234 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y.: "Nonparametric regression analysis of functional brain images"Journal of the Japan Institute of Electronics, Information and Communication Engineers. 12. 2623-2633 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morita, C., Tsukimoto, H., Kakimoto, M., Kikuchi, Y.: "Knowledge discovery from functional brain images by logical regression analysis"Transactions of the Japanese Society for Artificial Intelligence. 16. 212-219 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y.: "Intelligent analysis of fMRI images by logical regression analysis"The transaction of IEEJ (The Institute of Electrical Engineers of Japan). IM-01-58. 21-26 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka, M., Kikuchi, Y., Sato, T., Mori, T.: "Basic Investigation on brain activity by using f-MRI"The transaction of IEEJ (The Institute of Electrical Engineers of Japan). IM-01-59. 27-30 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hatakeyama, E., Miyazaki, Y., Kikuchi, Y., Ishikawa, N., Yamaguchi, M.: "A study of the influence of food and music (sound) on the sense of wellbeing based on a Life Science perspective"Report of Kansei Fukushi Research Center. 2. 127-133 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishimura, C., Kumagai, T., Kikuchi, Y., Endo, H., J. Nenonen, R. J. Iimoniemi and T. Katila, eds.: "Neuromagnetic fields elicited by multimodal inputs, in Vision of Biomag 2000"Helsinki Univ. of Technology. 141-215 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y., Hatakeyama, E. and Miyazaki, Y.: "Rule discovery from fMRI brain images by logical regression analysis, in Progress in Discovery Science"Springer-Verlag. 232-245 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y., et al.: "Rule discovery from fMRI brain images by logical regression analysis"Progress in Discovery Science, Springer-Verlag Berlin, Heidelberg, New York. 232-245 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 畠山英子, 石川宣子, 菊池吉晃, 他: "生命科学を基礎とする感性と食環境ならびに音・音楽環境の相関に関する研究"東北福祉大学感性福祉研究所研究報告書. 62-65 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大渕 新, 乳井嘉之, 篠原広行, 菊池吉晃: "MRI2次元フーリエ変換法における位相エンコード数と再構成像の関係"第8回東京保健科学学会学術集会抄録集. 34 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大渕 新, 乳井嘉之, 篠原広行, 菊池吉晃: "MRIスピンエコー法の計算機シミュレーション"第8回東京保健科学学会学術集会抄録集. 35 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 栃木捷一郎, 渡邊 修, 木下正信, 菊池吉晃, 笠井久隆, 米本恭三: "片側性大脳半球血管障害例における定量的脳幹誘発電筋電図所見"第40回日本リハビリテーション医学会学術集会. (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 月本洋, 柿本満, 森田千絵, 菊池吉晃: "脳機能画像のノンパラメトリック回帰分析"電子情報通信学会論文誌. J84-D-II. 2623-2633 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nishimura, C., Kumagai, T., Kikuchi, Y., Endo, H.: "Neuromagnetic fields elicited by a bimodal input"Biomag 2000, Proceedings of the 12^<th> International Conference on Biomagnetism (J.Nenonen, R.J.Iimoniemi and T.Katila eds.)Helsinki University of Technology, Espoo, Finland. 141-215 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 菊池吉晃, 田中雅行, 西村千秋, 吉澤修治: "高時間分解能の複数電流双極子推定による感覚情報の弁別処理機構について"日本電気学会計測研究会資料. IM-01-55. 5-9 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 田中雅行, 菊池吉晃, 佐藤知正: "fMRIを用いた脳活動の基礎検討"日本電気学会計測研究会資料. IM-01-59. 27-30 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 月本洋, 柿本満, 森田千絵, 菊池吉晃: "論理回帰分析によるfMRI画像の知的分析"日本電気学会計測研究会資料. IM-01-58. 21-26 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 菊池吉晃, 米本恭三: "左右手判別に伴う脳内活動の時間構造-脳磁界の解析から-"リハビリテーション医学. Vol.38. S234 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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