Basic and clinical research of endovascular therapy for intracranial atherosclerosis lesions
| Project/Area Number |
13671455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
TERADA Tomoaki Wakayama Medical University, Department of Neurological Surgery, Associate Professor, 医学部, 助教授 (60227519)
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| Co-Investigator(Kenkyū-buntansha) |
津浦 光晴 和歌山県立医科大学, 医学部, 講師 (70254555)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | intracranial artery / atherosclerosis / endovascular therapy / stent / atherosclerosis / intracronical artery / PTA / stent / endovascular therapy / brain / intracranical artery / bFGF / VEGF / cerebral artory / compls cation |
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| Research Abstract |
1)Patency of the perforation artery after stent placement for the intracranial artery : In atherosclerosis induced rabbits, the orifice of the lumbar artery showed narrowing due to the proliferation of the intima around stent strut. However, most of cases, the lumbar artery was patent. These changes were different from those seen in normal rabbits.
2)Results of clinical cases: 31 cases with intracranial atherosclerotic stenosis were treated with stenting. In three cases with total occlusion, one case showed re-occlusion in spite of the successful stenting and two cases showed restenosis. The rate of abnormality demonstrated in diffusion weighted MRI was small in number compared with carotid stenting. In 26 cases, long-term patency and stroke prevention was confirmed. Form these points, intracranial stenting was safe and effective.
3)PVA coated covered stent : VEGF and bFGF were dissolved in the PVA polymer and released after stent placement. However, these materials were released within 24 hours. Slower release may be preferable for clinical use.
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Report
(4 results)
Research Products
(9 results)
