| Project/Area Number |
13671476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
NAKANO Atsuhisa Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (70258151)
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| Co-Investigator(Kenkyū-buntansha) |
IKEMOTO Hideyasu Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (30278824)
ARITA Norio Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (80159508)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | metalloproteinase / invasion / glioma / 浸潤 / 浸潤能 |
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| Research Abstract |
A cDNA encoding a new member of the membrane-type (MT) matrix metalloproteinase (MMP) family has been identified and cloned from a human brain cDNA library. This novel human MMP has been called MT5-MMP because it represents the fifth member of the MT-MMP subfamily of MMPs. Northern blot analysis demonstrated that MT5-MMP is predominantly expressed in brain, kidney, pancreas, and lung. In addition, MT5-MMP transcripts were detected at high levels compared to normal brain tissue in a series of brain tumors, including astrocytomas and glioblastomas. The catalytic domain of MT5-MMP exhibits a potent proteolytic activity against progelatinase A, leading to the generation of the Mr 62,000 active form of this enzyme. These data suggest that MT5-MMP may contribute to the activation of progelatinase A in tumor tissues, in which it is overexpressed, thereby facilitating tumor progression.
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