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Experimental Study of Spinal Reconstruction Using Bioabsorbable Material

Research Project

Project/Area Number 13671481
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

ABUMI Kuniyoshi  Hokkaido Univ., Health Administration Center, Prof, 保健管理センター, 教授 (00159419)

Co-Investigator(Kenkyū-buntansha) ITO Manabu  Hokkaido Univ., Hokkaido University Hospital, Lec, 病院・講師 (00271677)
KOTANI Yoshihisa  Hokkaido Univ., Hokkaido University Hospital, Assist, 病院・助手 (40312368)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
KeywordsAbsorbable Material / Spinal Reconstruction / Biomechanics / Intervertebral Disc Replacement / Artificial Intervertebral Disc / 脊椎 / 椎間板
Research Abstract

Objectives of the study were to evaluate the validity and advantage of forged composite of uncalcined hydroxyapatite Poly L-Lactite cage (F-u-HA/PLLA) radiographically, biomechanically, and histlogically when compared to conventional autologousiliac bone (AM) and carbon fiber cage (CFC). Twenty-five mature sheep underwent posterior lumbar interbody fusion at L2-3 level with pedide screw system. Three types of interbody fusion implants were grafted : AIB (n=7), CFC (n=9), F-u-HA/PLLA((n=9). Two types of cages were packed with autologous fragmented cancellous bone harvested locally. All animals were euthanized at 120 days after surgery. The fusion scoreing using the coronal view CT scans was designed to three dimentionally evaluate fusionquality within and around cages. The meen CT scores of threee groups were 33.3 points, 35.0 points, 33.6 points in AIB, CFC, and F-u-HA/PLLA cage groups, respectively (full-score : 56 points). Statistical differences were not detected among the three groups. The mean range of motion values among fused groups had no significant diffierence under all pure moment loadings. The range of motion showed strong and significant correlation with the CT fusion scores. Histologic results demonstrated that F-u-HA/PLLA cages contacted with the surrounding bone directly, and CFC was encircled with thick fibrous tissue layrs without any sign of inflammation around cages. The fusion quality of fused spinal segment using F-u-HA/PLLA cages was equal to that of AIB or CFC both radiographically and biomechanically. In the histological observation, biocompatibility of F-u-HA/PLLA cage was obviously superior to CFC. It has been confirmed that the novel bioactive and bioabsorbable cages had valuable advantages over existing CFC for use in spinal re constructive surgery.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (49 results)

All 2005 2004 2003 2002 2001 Other

All Journal Article (35 results) Publications (14 results)

  • [Journal Article] Cervical spine injuries associated with lateral mass and facet joint fracture : New classification and surgical treatment with pedicle screw fixation2005

    • Author(s)
      Kotani K, Abumi K, Ito M, Minami A.
    • Journal Title

      Eur Spine J 14

      Pages: 99-102

    • NAID

      120000963007

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Iliac crest reconstruction with a bioactive ceramic spacer2005

    • Author(s)
      Ito M, Abumi K, Moridaira H, Shono Y, Kotani Y, Minami A, Kaneda K
    • Journal Title

      Eur Spine J 14

      Pages: 994-999

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Minami A : A biomechanical and histological evaluation of a bioresorbable lumbar interbody fusion cage2005

    • Author(s)
      Hojo Y, Kotani Y, Ito M, Abumi K, Kadosawa T, Shikinami Y
    • Journal Title

      Biomaterials 26

      Pages: 2643-2651

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multidirectional flexibility analysis of cervical artificial disc reconstruction : In vitro human cadaveric spinal model2005

    • Author(s)
      Kotani Y, Cunningham BW, Abumi K, Dmitriew AE, Ito M, Hu Niabin, Shikinami Y, McAfee PC, Minami A
    • Journal Title

      J Neurosurg (Spine) 102

      Pages: 188-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cervical spine injuries associated with lateral mass and facet joint fracture : New classification and surgical treatment with pedicle screw fixation.2005

    • Author(s)
      Kotani K, Abumi K, Ito M, Minami A
    • Journal Title

      Eur Spine J 14

      Pages: 69-77

    • NAID

      120000963007

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Iliac crest reconstruction with a bioactive ceramic spacer.2005

    • Author(s)
      Ito M, Abumi K, Moridaira H, Shone Y, Kotani Y, Minami A, Kaneda K
    • Journal Title

      Eur Spine J 14

      Pages: 99-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multidirectional flexibility analysis of cervical artificial disc reconstruction : In vitro human cadaveric spinal model.2005

    • Author(s)
      Kotani Y Cunningham BW, Abumi K, Dmitriew AE, Ito M, Hu Niabin, Shikinami Y, McAfee PC, Minami A
    • Journal Title

      J Neurosurg Spine 2

      Pages: 188-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A biomechanical and histological evaluation of a bioresorbable lumbar interbody fusion cage2005

    • Author(s)
      Hojo Y, Kotani Y, Ito M, Abumi K, Kadosawa T, Shikinami Y, Minami A
    • Journal Title

      Biomaterials 26

      Pages: 2643-2651

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Two-year observation of artificial intervertebral disc replacement : results after supplemental ultra-high strength bioresorbable spinal stabilization2004

    • Author(s)
      Kotani Y, Abumi K, Shikinami Y, Takahata M, Kadoya K, Kadisawa T, Minami A, Kaneda K
    • Journal Title

      J Neurosurg (Spine) 100

      Pages: 337-342

    • NAID

      120000957893

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A biomechanical analysis of metastatic vertebral collapse of the thoracic spine : a sheep model study2004

    • Author(s)
      Ebihara H, Ito M, Abumi K, Taneich H, Kotani Y, Minami A, Kaneda K.
    • Journal Title

      Spine 29

      Pages: 994-999

    • NAID

      10017377082

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A biomimetic artificial disc with improved properties compared to biological intervertebral discs.2004

    • Author(s)
      Shikinami Y, Kotani Y, Cunningham BW, Abumi K, Kaneda K.
    • Journal Title

      Adv Funct Mater 14

      Pages: 1039-1046

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Two-year observation of artificial intervertebral disc replacement : results after supplemental ultra-high strength bioresorbable spinal stabilization.2004

    • Author(s)
      Kotani Y, Abumi K, Shikinami Y, Takahata M, Kadoya K, Kadisawa T, Minami A, Kaneda K
    • Journal Title

      J Neurosurg (Spine) 100(4)

      Pages: 337-342

    • NAID

      120000957893

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A biomechanical analysis of metastatic vertebral collapse of the thoracic spine : a sheep model study.2004

    • Author(s)
      Ebihara H, Ito M, Abumi K, Taneich H, Kotani Y, Minami A, Kaneda K
    • Journal Title

      Spine 29

      Pages: 994-999

    • NAID

      10017377082

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A biomimetic artificial disc with improved properties compared to biological intervertebral discs.2004

    • Author(s)
      Shikinami Y, Kotani Y, Cunningham BW, Abumi K, Kaneda K
    • Journal Title

      Adv Fund Mater 14

      Pages: 1039-1046

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Two-year observation of artificial intervertebral disc replacement : results after supplemental ultra-high strength bioresorbable spinal stabilization2004

    • Author(s)
      Kotani Y, Abumi K, Shikinami Y, Takahata M, Kadova, et al.
    • Journal Title

      J Neurosurg (Spine) 100・4

      Pages: 337-342

    • NAID

      120000957893

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A biomimetic artificial disc with improved properties compared to biological intervertebral discs2004

    • Author(s)
      Shikinami Y, Kotani Y, Cunningham BW, Abumi K, Kaneda K
    • Journal Title

      Adv Funct Mater 14

      Pages: 1039-1046

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Bone ingrowth fixation of artificial intervertebral disc consisting of bioceramic coated three-dimensional fabric2003

    • Author(s)
      Takahata M, Kotani Y, Abumi K, Shikinami Y, Kadosawa T, Kaneda K
    • Journal Title

      Spine 28

      Pages: 637-644

    • NAID

      10017363964

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Types of spinal instability that require interbody support in posterior lumbar reconstruction. An in-vitro biomechanical investigation2003

    • Author(s)
      Oda I, Abumi K, Yu BS, Sudo H, Minami A
    • Journal Title

      Spine 28

      Pages: 1573-1580

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Static and dynamic analysis of five anterior instrumentation systems for thoracolumbar scoliosis2003

    • Author(s)
      Shimamoto N, Kotani Y, Shono Y, Kadoya K, Abumi K, Minami A, Kaneda K
    • Journal Title

      Spine 28

      Pages: 1678-1685

    • NAID

      10017368771

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] In vitro biomechanical effects of reconstruction on adjacent motion segment : comparison of aligned/kyphotic posterolateral fusion with aligned posterior lumbar interbody fusion/posterolateral fusion2003

    • Author(s)
      Sudo H, Oda I, Abumi K, Ito M, Kotani Y, Hojo Y, Minami A
    • Journal Title

      J Neurosurg (Spine) 99

      Pages: 221-228

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Bone ingrowth fixation of artificial intervertebral disc consisting of bioceramic coated three-dimensional fabric.2003

    • Author(s)
      Takahata M, Kotani Y, Abumi K, Shikinami Y, Kadosawa T, Kaneda K
    • Journal Title

      Spine 28

      Pages: 637-644

    • NAID

      10017363964

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Static and dynamic analysis of five anterior instrumentation systems for thoracolumbar scoliosis.2003

    • Author(s)
      Shimamoto N, Kotani Y, Shone Y, Kadoya K, Abumi K, Minami A, Kaneda K
    • Journal Title

      Spine 28

      Pages: 1678-1685

    • NAID

      10017368771

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] In vitro biomechanical effects of reconstruction on adjacent motion segment : comparison of aligned/kyphotic posterolateral fusion with aligned posterior lumbar interbody fusion/posterolateral fusion.2003

    • Author(s)
      Sudo H, Oda I, Abumi K, Ito M, Kotani Y, Hojo Y, Minami A
    • Journal Title

      J Neurosurg (Spine 2) 99

      Pages: 221-228

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An in-vitro human cadaveric study investigating the biomechanical properties of the thoracic spine2002

    • Author(s)
      Oda I, Abumi K, Cunningham BW, Kaneda K, McAfee PC
    • Journal Title

      Spine 27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Complications related hydroxyapatite vertebral spacer in anterior cervical spine surgery.2002

    • Author(s)
      Ito M, Abumi K, Shono Y, Kotani Y, Minami A, Kaneda K
    • Journal Title

      Spine 27

      Pages: 428-431

    • NAID

      10016392506

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Artificial intervertebral disc replacement using bioactive three-dimensional fabric. Design, development, and preliminary animal study2002

    • Author(s)
      Kotani Y, Abumi K, Kaneda K, Shikinami Y, Takada T, Kadoya K
    • Journal Title

      Spine 27

      Pages: 925-935

    • NAID

      10016393866

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of aging and spinal degeneration on mechanical properties of lumbar supraspinous and interspinous igaments2002

    • Author(s)
      Iida T, Abumi K, Kotani Y, Kaneda K
    • Journal Title

      Spine Journal 2

      Pages: 95-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An in-vitro human cadaveric study investigating the biomechanical properties of the thoracic spine.2002

    • Author(s)
      Oda I, Abumi K, Cunningham BW, Kaneda K, McAfee PC
    • Journal Title

      Spine 27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Complications related hydroxyapatite vertebral spacer in anterior cervical spine surgery.2002

    • Author(s)
      Ito M, Abumi K, Shone Y, Kotani Y, Minami A, Kaneda K
    • Journal Title

      Spine 27

      Pages: 428-431

    • NAID

      10016392506

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Artificial intervertebral disc replacement using bioactive three-dimensional fabric. Design, development, and preliminary animal study.2002

    • Author(s)
      Kotani Y, Abumi K, Kaneda K, Shikinami Y, Takada T, Kadoya K, Shimamoto N, Ito M, Shone Y, Kadosawa T, Fujinaga T
    • Journal Title

      Spine 27

      Pages: 925-935

    • NAID

      10016393866

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of aging and spinal degeneration on mechanical properties of lumbar supraspinous and interspinous igaments.2002

    • Author(s)
      Iida T, Abumi K, Kotani Y, Kaneda K
    • Journal Title

      Spine Journal 2

      Pages: 95-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Biomechanical and morphological evaluation of sheep artificial intervertebral disc using three-dimensional fabric- In vitro and in vivo analysis.2001

    • Author(s)
      Kadoya K, Kotani Y, Abumi K, Takada T, Shimamoto M, Isayama H, Shikinami Y, Kadosawa T, Kaneda K
    • Journal Title

      Spine 26

      Pages: 1562-1569

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Biomechanical and morphological evaluation of sheep artificial intervertebral disc using three-dimentional fabric In vitro and in vivo analysis.2001

    • Author(s)
      Kadoya K, Kotani Y, Abumi K, Takada T, Shimamoto M, Isayama H, Shikinami Y, Kadosawa T, Kaneda K
    • Journal Title

      Spine 26

      Pages: 1562-1569

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Types of spinal instability that require interbody support in posterior lumbar reconstruction. An in-vitro biomechanical investigation.

    • Author(s)
      Oda I, Abumi K, Yu BS, Sudo H, Minami A
    • Journal Title

      Spine 28

      Pages: 1573-1580

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A biomechanical and histological evaluation of a bioresorbable lumbar interbody fusion cage.

    • Author(s)
      Hojo Y, Kotani Y, Ito M, Abumi K, Kadosawa T, Shikinami Y, Minami A
    • Journal Title

      Biomaterials 26

      Pages: 2643-2651

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Oda I, Abumi K, Yu BS, Sudo H, Minami A: "Types of spinal instability that require interbody support in posterior lumbar reconstruction. An in-vitro biomechanical investigation."Spine. 28. 1573-1580 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahata M, Kotani Y, Abumi K, Shikinami Y, Kadosawa T, Kaneda K: "Bone ingrowth fixation of artificial intervertebral disc consisting of bioceramic coated three-dimensional fabric."Spine. 28. 637-644 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sudo H, Oda I, Abumi K, Ito M, Kotani Y, Hojo Y, Minami A: "In vitro biomechanical effects of reconstruction on adjacent motion segment : comparison of aligned/kyphotic posterolateral fusion with aligned posterior lumbar interbody fusion/posterolateral fusion."J Neurosurg. 99(Spine 2). 221-228 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Abumi K, Ito M, Kotani Y: "In The Cervical Spine Surgery Atlas, 2^<nd> Edition. Pp411-422, Ed by Cervical Spine Research Society"Lippincott Williams Wilkins. 11 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kotani Y, Abumi K, Kaneda K, et al.: "Artificial intervertebral disc replacement using bioactive three-dimensional fabric Design, development, and preliminary animal study"Spine. 27. 925-935 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iida T, Abumi K, Kotani Y, Kaneda K: "Effects of aging and spinal degeneration on mechanical properties of lumbar supraspinous and interspinous igaments"Spine Journal. 2. 95-100 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鐙 邦芳, 放生憲博: "生体内吸収性材料の脊椎外科への応用の可能性"関節外科. 21. 52-56 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 小谷善久, 鐙 邦芳, 三浪明男: "人工椎間板"現代医療. 34. 131-133 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Abumi K, Ito M, Kotani Y: "Seminors in Spine Surgery Ed by Wiezel SM and Boden SD"WB Saunders. 112-124 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kadoya K., Kotani Y., Abumi K., Takada T., Shimamoto M., Isayama H., Shikinami Y., Kadosawa T., Kaneda K.: "Biomechanical and morphological evaluation of sheep artificial intervertebral disc using three-dimentional fabric-In vitro and in vivo analysis"Spine. 26. 1562-1569 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Oda I., Abumi K., Cunningham BW., Kaneda K., McAfee PC.: "An in-vitro human cadaveric study investing the biomechanical properties of the thoracic spine"Spine. 27. E64-70 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ito M., Abumi K., Shono Y., Kotani Y., Minami A., Kaneda K.: "Complications related hydroxyapatite vertebral spacer in anterior cervical spine surgery"Spine. 27. 428-431 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kotani Y., Abumi K., Kaneda K., et al: "Artificial intervertebral disc replacement using bioactive three-dimensional fabric. Design, development, and preliminary animal study"Spine. Feb(in press)(issue). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 鐙 邦芳: "人工骨による脊柱再建"THE BONE. 15. 477-481 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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