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Reconstruction of ligament using mesenchymal stem cells

Research Project

Project/Area Number 13671489
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionGunma University

Principal Investigator

TAKAGISHI Kenji  Gunma Univ., Medicine, Professor, 医学部, 教授 (70154763)

Co-Investigator(Kenkyū-buntansha) SHINOZAKI Tetsuya  Gunma Univ., Medicine, Assistant Prof., 医学部, 講師 (90251115)
WATANABE Hideomi  Gunma Univ., Medicine, Associate Prof., 医学部, 助教授 (40231724)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsMesenchymal stem cells / 靭帯 / 靱帯 / 骨髄 / 幹細胞 / 軟骨
Research Abstract

Mesenchymal stem cells harvested from the bone marrow are cultured in vitro and differentiated into the objected cells to repair the tissue defect. However, ligament tissue is hard to make. In this study, we tried to make the ligament tissue using stem cells. Stem cells were harvested from bone marrow in the rabbit and proliferated and embedded in the type I collagen gel. Stem cells secreted the type I collagen and present same character as the cells in the ligament. Cells differentiated into the cartilage cells showed the type II collagen.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Ahmed A.R., et al.: "Reconstruction with autologous pasteurized whole knee joint I experimental study in a rabbit model."Journal of Orthopaedic Science. 8. 170-179 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Watanabe H. et al.: "Reconstruction with autologous pasteurized whole knee joint II application for Osteosarcoma of the proximal tibia."Journal of Orthopaedic Science. 8. 180-186 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Higuchi H. et al.: "The relation between static and dynamic knee stability afterACL reconstruction."Acta Orthopaedic Belgica. 69. 257-266 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kanbe K., et al.: "Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis."J Bone joint Surg.. 86-B. 296-300 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ahmed A.R., et al.: "Reconstruction with autologous pasteurized whole knee joint : experimental study in a rabbit model."Journal of Orthopaedic Science. 8. 170-179 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Watanabe H.et al.: "Reconstruction with autologous pasteurized whole knee joint II : application for Osteosarcoma of the proximal tibia."Journal of Orthopaedic Science. 8. 180-186 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Higuchi H.et al.: "The relation between static and dynamic knee stability after ACL reconstruction."Acta Orthopaedic Belgica. 69. 257-266 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kanbe K., et al.: "Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis."J Bone joint Surg.. 86-B. 296-300 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ahmed A.R., et al.: "Reconstruction with autologous pasteurized whole knee joint I experimental study in a rabbit model."Journal of Orthopaedic Science. 8. 170-179 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watanabe H.et al.: "Reconstruction with autologous pasteurized whole knee joint II : application for Osteosarcoma of the proximal tibia."Journal of Orthopaedic Science. 8. 180-186 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Higuchi H.et al.: "The relation between static and dynamic knee stability afterACL reconstruction."Acta Orthopaedic Belgica. 69. 257-266 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanbe K., et al.: "Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis."J Bone joint Surg.. 86-B. 296-300 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yanagawa T et al.: "Expression of bone formation-related molecules in a newly established protein-independent osteosecoma"Int. J. Oncol.. 18. 1195-1205 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yanagawa T. et al.: "The natural history of disappearing bone tumours and tumour-like conditions"Clin. Radiol.. 56. 877-886 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Adel AR. et al.: "The role of PET in the preoperative planning"Eur. J. Nucl. Med.. 28. 1541-1551 (2001)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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