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An investigation of underlying mechanism of delayed inflammatory state and hyperalgesia located in a healed wound-A study of involvement of sympathetic activity and possibility of therapeutical effect of preemptive sympathectomy

Research Project

Project/Area Number 13671503
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

NAKAMURA Ryogo  Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (10115610)

Co-Investigator(Kenkyū-buntansha) SATO Jun  Nagoya University, Research Institute of Environmental Medicine, Associate Professor, 環境医学研究所, 助教授 (00235350)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsSYMPATHETIC NERVE / HYPERALGESIA / NORADRENALINE / ATP / CHRONIC PAIN / アジュバント関節炎ラット / 痛覚線維 / 低気圧環境 / 低温環境
Research Abstract

1, Preemptive sympathectomy prevented the development of inflammatory changes (swelling, redness) in the hindpaw, while but not influence the augmenting effects of noradrenaline on the C-fiber nociceptors of chronic inflamed rats. This suggests fundamental differences of underlying mechanism between developments of inflammatory process and adrenergic sensitivity of nociceptors under chronic inflamed condition.
2, There was a clear development of daily change in plasma noradrenaline in rats rendered neuropathic. This suggests that sympathetic activity is not stable through the whole period of CRPS.
3, Low concentration of ATP (a mimic dose of sympathetic transmitter) excited some of the CPRs after heat stimulations, but the subsequent heat responses were decreased. Higher concentration of ATP (a mimic dose of damaged cell) excited some CPRs and increased the heat responses. ATP seems not to have a predominant role in the sympathetically maintained hyperalgesia in CRPS.
4, There were clear differences between the Lewis strain and Sprague-Dawley rate in chronic inflammation induced noradrenaline sensitivity of cutaneous C-fiber nociceptors. This suggests that wide rage of therapeutic effect of sympathectomy is due to difference of sympathetic dependency of each subject.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Nakamura R.: "Diagnosis of ulnar wrist pain"Nagoya Journal of Medical Science. 64. 81-91 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Banik R.K.: "Differences between the Lewis and Sprague Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors"Neuroscience Letters. 299. 21-24 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, Y.: "Lowered response threshold and increased responsiveness to mechanical stimulation of cutaneous nociceptive fibers in streptozotocin-diabetic rat sin in vitro -correlates of mechanical allodvnia and hyperalgesia observed in the early stage of diabetes"Neuroscience Research. 43. 475-484 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中尾悦宏: "手関節痛を生じる手根不安定症の診断と治療"整形・災害外科. 44(2). 145-153 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤 純: "糖尿病ラットの皮膚痛覚線維活動"末梢神経. 12. 137-140 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤 純: "慢性疼痛と交感神経"CLINICAL NEUROSCIENCE (月刊臨床神経科学). 20. 1132-1133 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura R.: "Diagnosis of ulnar wrist pain"Nagoya Journal of Medical Science. 64. 81-91 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Banik R.K.: "Differences between the Lewis and Sprague Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors"Neuroscience Letters. 299. 21-24 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki,Y.: "Lowered response threshold and increased responsiveness to mechanical stimulation of cutaneous nociceptive fibers in streptozotocin-diabetic rat sin in vitro - correlates of mechanical allodynia and hyperalgesia observed in the early stage of diabetes"Neuroscience Research. 43. 475-484 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakao,E.: "Diagnosis and treatment for carpal instability"Orthopaedic Surgery and Traumatology. 44-2. 145-153 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato,J.: "Cutaneous nociceptor activity in diabetic rats"Peripheral Nerve. 12. 137-140 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato,J.: "Chronic pain and sympathetic nerve"Clinical Neuroscience. 20. 1132-1133 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, Y.: "Lowered response threshold and increased responsiveness to mechanical stimulation of cutaneous nociceptive fibers in streptozotocin-diabetic rat sin in vitro -correlates of mechanical allodynia and hyperalgesia observed in the early stage of diabetes"Neuroscience Research. 43(2). 475-484 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi, K., et al.: "Artificially Produced Meteorological Changes Aggravate Mechanical Allodynia in Adjuvant Induced Arthris Rats"Society for Neuroscience Abstracts. 27. 508 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yajima H., et al.: "Noradrenaline but no ATP sensitized the heat respouse of cutaneous nociceptors in chronically inflamea rats"Society for Neuroscience Abstracts. 27. 508 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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