| Project/Area Number |
13671505
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
NEO Masashi Kyoto University, Faculty of Medicine, Lecturer, 医学研究科, 講師 (80311736)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takashi Kyoto University, Faculty of Medicine, professor, 医学研究科, 教授 (10201675)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Artificial bone / Growth factor / Hydroxyapatite / Bioactivity / Porous / D-FGF / Bone formation / 生体活性セラミック / マイクロCT / 血管新生 / バイオミメティック法 / 生体活性材料 |
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| Research Abstract |
The purpose of this study is to create an artificial bone that has a comparable bone-forming ability to natural bone by adding growth factors to bioactive ceramics
1: Enhancement of bone-bonding ability by TAK-778
TAK778 is a newly formed low molecular agent, which may exert regulatory effects on osteoblast differentiation. This agent was applied to the interface between bioactive ceramics and bone at implantation, which demonstrated that TAK-778 enhanced the bone bonding strength of the ceramics
2: Absorption of porous AW
Cylinders of porous AW or porous HA (porosity 70% and mean pore diameter 200 urn for both materials) were implanted into the bone marrow cavity of rabbit femurs, and analyzed chronologically. AW was absorbed continuously, and at 12 months the residual material corresponded to about 30% of the starting material, whereas HA was hardly absorbed. The volume of newly formed bone in the material pores was higher with AW than with HA. AW-bone bonding was maintained during bone remodeling and material absorption. Thus porous AW showed faster absorption and greater bone ingrowth than HA, suggesting better suitability for a carrier of growth factors
3: Boneforming ability of AW-b-FGF complex
Porous AW cylinders were soaked in the solution of b-FGF under high vacuum and were implanted into rabbit femur. Although more vascular formation into the pores was observed in FGF group than control (AW without b-FGF), the amounts of bone formation were comparable
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