MRI evaluation of cruciate ligaments-bone junction in rheumatoid arthritis.
| Project/Area Number |
13671543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | JIKEI UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
FUJII Katsuyuki Jikei University, School of Medicine Department of Orthopaedic Surgery, Professor, 医学部, 教授 (10112856)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Maki Jikei University, School of Medicine,Department of Orthopaedic Surgery, Research Assistant, 医学部, 助手 (00266701)
TSUJI Michiko Jikei University, School of Medicine Department of Orthopaedic Surgery, Lecture, 医学部, 講師 (80207365)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Rheumatoid arthritis / Cruciate ligaments - bone junction / Collagen - induced arthritis / MRI / 膝関節内靱帯付着部 |
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| Research Abstract |
In some of the rheumatoid arthritis (RA) patients, with therapeutically controlled synovial inflammation, cartilage destruction silently progresses, eventually leading to arthroplasty. Initiation and primary changes of joint destruction in RA have not yet been clarified. Inorder to approach the pathogenesis of joint destructionin RA, we examined serum levels of atiti-type II collagen antibodies and microscopic changes accompanying cartilage degeneration in collagen-induced arthritis(CIA). The early phase of cartilage degeneration was examined in order to evaluate of cruciate ligaments-bone junction in RA by MRI. In CIA, the periphysis and its surroundings form the junction between cartilage and bone marrow, corresponding to the subchondral area in humans.
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Report
(3 results)
Research Products
(6 results)
