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MRI evaluation of cruciate ligaments-bone junction in rheumatoid arthritis.

Research Project

Project/Area Number 13671543
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionJIKEI UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

FUJII Katsuyuki  Jikei University, School of Medicine Department of Orthopaedic Surgery, Professor, 医学部, 教授 (10112856)

Co-Investigator(Kenkyū-buntansha) TANAKA Maki  Jikei University, School of Medicine,Department of Orthopaedic Surgery, Research Assistant, 医学部, 助手 (00266701)
TSUJI Michiko  Jikei University, School of Medicine Department of Orthopaedic Surgery, Lecture, 医学部, 講師 (80207365)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsRheumatoid arthritis / Cruciate ligaments - bone junction / Collagen - induced arthritis / MRI / 膝関節内靱帯付着部
Research Abstract

In some of the rheumatoid arthritis (RA) patients, with therapeutically controlled synovial inflammation, cartilage destruction silently progresses, eventually leading to arthroplasty. Initiation and primary changes of joint destruction in RA have not yet been clarified. Inorder to approach the pathogenesis of joint destructionin RA, we examined serum levels of atiti-type II collagen antibodies and microscopic changes accompanying cartilage degeneration in collagen-induced arthritis(CIA). The early phase of cartilage degeneration was examined in order to evaluate of cruciate ligaments-bone junction in RA by MRI. In CIA, the periphysis and its surroundings form the junction between cartilage and bone marrow, corresponding to the subchondral area in humans.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

Research Products

(6 results)

All Other

All Publications (6 results)

  • [Publications] 田中真希: "慢性関節リウマチの傍関節性骨萎縮の病態 -破骨細胞、骨細胞を中心とした病理組織学的検討-"日本整形外科学会雑誌. 75・8. S1048 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 山岸 千晶: "慢性関節リウマチ罹患関節における十字靭帯付着部のMRI所見"日本リウマチ・関節外科学会雑誌. 21. S118 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Tanaka, et al.: "Histopathologic studies on osteoclasts and osteocytes in periarticular atrophic bone tissue of rheumatoid arthritis."J. Jpn. Orthop. Assoc.. 75(8). S1048 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] C. Yamagishi, et al.: "MRI evaluation of cruciate ligament-bone junction in rheumatoid arthritis."Jpn. J. Rheum. Joint Surg.. 21. S118 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 田中真希: "慢性関節リウマチの関節内靭帯病変-コラーゲン誘導関節炎ラットの十字靭帯付着部の病理組織学的検討"日本整形外科学会雑誌. 74・8. S1482 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 田中真希: "慢性関節リウマチの傍関節性骨萎縮の病態-破骨細胞、骨細胞を中心とした病理組織学的検討-"日本整形外科学会雑誌. 75・8. S1048 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-03-31   Modified: 2016-04-21  

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