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Correlation between Histological Degree of Chondrosarcoma and Detection of MMps, ADAMTSs and TIPs

Research Project

Project/Area Number 13671546
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNihon University School of Medicine

Principal Investigator

SHUNZO Osaka  Nihon University School of Medicine, Department of Orthopaedic Surgery, Nihon University School of Medicine, 助教授 (30158795)

Co-Investigator(Kenkyū-buntansha) SUGITANI Masahiko  Nihon University, Department of Pathology, 助教授 (40187654)
YOSHIDA Yukihiro  Nihon University, Department of Orthopaedic Surgery, 講師 (20201022)
川野 壽  日本大学, 医学部, 助教授 (00150706)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsChondrosarcoma / Malignancy / Immunochemstry / Prognosis / Matrx metalloproteinase / A disintegrin and metalloproteinase / Tissue inhibitor of metalloproteinases / 軟骨系腫瘍 / マトリックスメタプロテアーゼ / 軟骨系良性腫瘍 / Matrix Metalloproteinase
Research Abstract

Background: Malignant degree of human chondrosarcoma can be difficult to determine using only histological findings. We therefore assessed expressions of matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase (ADAM) with thrombospondin motifs (ADAMTSs) and tissue inhibitor of metal I oprotei nases (TIMPs) in chondrosarcoma and ascertained relationships to histological degree of malignancy and prognosis.
Materials and Methods: In 28 chondrosarcoma patients, inimunostaining was performed using antibodies for each of the proteins of MMP-2, 3, 7, 9, 13, ADAMTS-4, 5 and TIMP-1, 2, 3.
Results: Chondrosarcoma were classified into 7, 15 and 6 cases in histologically malignant grade I, 11 and 111, respectively. All target proteins were expressed in. chondrosarcoma. Positive correlations (p<0.05) existed between immunostaining scores and histological grades for all proteins except MMP 9, with strong correlations (p<0.01) for MMPs 2, 3 and 13, both ADAMTSs and all 3 TIMPs. No correlation existed between prognosis and immunostaining scores.
Conclusions: These proteins could thus indicate degree of malignancy in human chondrosarcoma.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (6 results)

All 2004 Other

All Journal Article (5 results) Publications (1 results)

  • [Journal Article] 軟骨肉腫におけるmmp-2,9,TIMP-1,2の免疫組織学的検討2004

    • Author(s)
      大幸俊三、杉谷雅彦, 吉田行弘
    • Journal Title

      関東骨軟部腫瘍の基礎を語る会雑誌 1

      Pages: 8-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] 軟骨肉腫におけるMMps, TIMPs, ADAMs免疫組織学的検討:追加研究

    • Author(s)
      大幸俊三、杉谷雅彦, 吉田行弘
    • Journal Title

      日本癌治療学会雑誌(抄録)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Correlation between histological degree of chondrosarcoma and expression of MMPs, ADAMTSs and TIMPs

    • Author(s)
      Shunzo Osaka, Masahiko Sugitani、Yukihiro Yoshida
    • Journal Title

      Anticancer Research (投稿中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Study of human cartilage tumor and matrix metalloproteinase

    • Author(s)
      Osaka S, Yoshida Y, Sugitani Y
    • Journal Title

      First Meeting of Basic Science in Bone and Soft Tissue Tumor

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Correlation between histological degree of chondrosarcoma and detection of MMPs, ADAMTSs and T1MPs

    • Author(s)
      Osaka S, Yoshida Y, Sugitani Y
    • Journal Title

      Anticancer Research (waiting)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 大塚俊三他: "軟骨肉腫におけるMMP-2,MMP-9,TIMP-1,TIMP-2の免疫組織学的検討"第1回関東骨軟部腫瘍の基礎を語る会. 4 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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