Correlation between Histological Degree of Chondrosarcoma and Detection of MMps, ADAMTSs and TIPs
| Project/Area Number |
13671546
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nihon University School of Medicine |
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Principal Investigator |
SHUNZO Osaka Nihon University School of Medicine, Department of Orthopaedic Surgery, Nihon University School of Medicine, 助教授 (30158795)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITANI Masahiko Nihon University, Department of Pathology, 助教授 (40187654)
YOSHIDA Yukihiro Nihon University, Department of Orthopaedic Surgery, 講師 (20201022)
川野 壽 日本大学, 医学部, 助教授 (00150706)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Chondrosarcoma / Malignancy / Immunochemstry / Prognosis / Matrx metalloproteinase / A disintegrin and metalloproteinase / Tissue inhibitor of metalloproteinases / 軟骨系腫瘍 / マトリックスメタプロテアーゼ / 軟骨系良性腫瘍 / Matrix Metalloproteinase |
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| Research Abstract |
Background: Malignant degree of human chondrosarcoma can be difficult to determine using only histological findings. We therefore assessed expressions of matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase (ADAM) with thrombospondin motifs (ADAMTSs) and tissue inhibitor of metal I oprotei nases (TIMPs) in chondrosarcoma and ascertained relationships to histological degree of malignancy and prognosis.
Materials and Methods: In 28 chondrosarcoma patients, inimunostaining was performed using antibodies for each of the proteins of MMP-2, 3, 7, 9, 13, ADAMTS-4, 5 and TIMP-1, 2, 3.
Results: Chondrosarcoma were classified into 7, 15 and 6 cases in histologically malignant grade I, 11 and 111, respectively. All target proteins were expressed in. chondrosarcoma. Positive correlations (p<0.05) existed between immunostaining scores and histological grades for all proteins except MMP 9, with strong correlations (p<0.01) for MMPs 2, 3 and 13, both ADAMTSs and all 3 TIMPs. No correlation existed between prognosis and immunostaining scores.
Conclusions: These proteins could thus indicate degree of malignancy in human chondrosarcoma.
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Report
(3 results)
Research Products
(6 results)
