A study on the mechanism of General Anesthesia-inuduced sleep-relation to endogenous sleep related substances
| Project/Area Number |
13671560
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Hirosaki University |
|---|
Principal Investigator |
MATSUKI Akitomo Hirosaki University School of Medicine Professor, 医学部, 教授 (20003543)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Takeshi Hirosaki University, University Hospital Instructor, 医学部附属病院, 医員
KUSHIKATA Tetsuya Hirosaki University, University Hospital Instructor, 医学部附属病院, 医員 (80250603)
HIROTA Kazuyoshi Hirosaki University, University Hospital Lecturer, 医学部附属病院, 講師 (20238413)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | General anesthetic agents / Sleep / Noradrenaline / Sleep Related Substance |
|---|
| Research Abstract |
We studied an interaction among general anesthetics and endogenous sleep-related substance. It is suggested that post anesthesia sleep was affected by ketamine, a general anesthetics. We found that non-rapid eye movement sleep (NREMS) was reduced but REMS was increased after a few days later of ketamine anesthesia On the other hand, orexin, a wake-promote substance thus sleep-related substance, decreased anesthesia-induced loss of consciousness duration by several intravenous general anesthetics ; pentobarbital, thiopental and phenobarbital. Our results suggest that there would be some interaction among general anesthetics and endogenous sleep-related substance.
|
Report
(3 results)
Research Products
(5 results)
