| Project/Area Number |
13671560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hirosaki University |
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Principal Investigator |
MATSUKI Akitomo Hirosaki University School of Medicine Professor, 医学部, 教授 (20003543)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Takeshi Hirosaki University, University Hospital Instructor, 医学部附属病院, 医員
KUSHIKATA Tetsuya Hirosaki University, University Hospital Instructor, 医学部附属病院, 医員 (80250603)
HIROTA Kazuyoshi Hirosaki University, University Hospital Lecturer, 医学部附属病院, 講師 (20238413)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | General anesthetic agents / Sleep / Noradrenaline / Sleep Related Substance |
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| Research Abstract |
We studied an interaction among general anesthetics and endogenous sleep-related substance. It is suggested that post anesthesia sleep was affected by ketamine, a general anesthetics. We found that non-rapid eye movement sleep (NREMS) was reduced but REMS was increased after a few days later of ketamine anesthesia On the other hand, orexin, a wake-promote substance thus sleep-related substance, decreased anesthesia-induced loss of consciousness duration by several intravenous general anesthetics ; pentobarbital, thiopental and phenobarbital. Our results suggest that there would be some interaction among general anesthetics and endogenous sleep-related substance.
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