| Project/Area Number |
13671566
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
MURAKAWA Yuji The University of Tokyo, Faculty of Medicine, research associate, 医学部附属病院, 助手 (20239510)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
|
|---|
| Keywords | Defibrillation / Defibrillation threshold / Autonomic nerve system / Implantable cardioverter-defibrillator / Ventricular fibrillation / 除細動閾値 / 心室細動 / 迷走神経 |
|---|
| Research Abstract |
The efficacy of electrical defibrillation is considered to be related to the autonomic status. In search of a possible adjunct to enhance the therapeutic performance of implantable cardioverter-defibrillator, we investigated whether parasympathetic manipulation by cervical vagal nerve stimulation (VNS) increases defibrillation efficacy. In fifty-five anesthetized dogs, effects of VNS on transcardiac defibrillation threshold (DFT) were assessed. In neurally intact dogs, right and left unilateral VNS at 10 mA for 7 sec significantly decreased the DFT after 10 sec of ventricular fibrillation (control : 3.1 ± 0.9 J, right : 2.1± 0.9 J [ Δ -35 ± 12%, p<0.0001], left : 2.2 ±0.8 J [ Δ -31± 11%, p<0.0005]), while bilateral VNS did not (2.8± 1.0 J). In dogs with decentralized vagus nerves, both unilateral and bilateral VNS decreased the DFT. The extent of the VNS-induced decrease in DFT was dependent on the current and the duration of stimulation. These results suggest that unilateral VNS decreases the DFT, while bilateral VNS paradoxically has no effect on the DFT unless the vagi are decentralized.
|
