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Mechanisms of neuronal cell death and treatments after spinal cord ischemia

Research Project

Project/Area Number 13671606
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNara Medical University

Principal Investigator

KAWAGUCHI Masahiko  Nara Medical University, Dept.of Anesthesiology, Assistant Professor, 医学部, 講師 (60275328)

Co-Investigator(Kenkyū-buntansha) INOUE Satoki  Nara Medical University, Dept.of Anesthesiology, Assistant Professor, 医学部, 講師 (50295789)
FURUYA Hitoshi  Nara Medical University, Dept.of Anesthesiology, Professor, 医学部, 教授 (70183598)
坂本 尚典  奈良県立医科大学, 医学部, 講師 (40275334)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
KeywordsSpinal cord ischemia / cell death / rat / 神経保護 / 白質 / 神経細胞 / 脊椎虚血 / アポトーシス
Research Abstract

For the assessments of spinal cord injury following the spinal cord ischemia, gray matter injury has been mainly focused as a target for therapy, because of traditional view that white matter is less vulnerable to ischemic injury compared with the gray matter. However, recent evidence suggested an importance of white matter injury as well as gray matter injury following spinal cord ischemia. We quantitatively assessed the gray and white matter injury following spinal cord ischemia in rats. Spinal cord ischemia(SCI) was induced with intra-aortic balloon catheter and hypotension. Twenty-four hours after reperfusion, hind limb motor function was assessed using Basso, Beattie, Bresnahan(BBB) scale scoring. The white matter damage was assessed on the basis of the extent of vacuolation and amyloid precursor protein(APP) immunoreactivity. The results indicated that both gray and white matters were injured following spinal cord ischemia in rats and the degree of white mater injury was well correlated with the severity of gray matter injury and hind-limb motor function. Although low-dose lidocaine did not affect the degree of gray and white matter injury, intra-thecal administration of delta opioid agonist SNC80 attenuated both gray and white matter injury following spinal cord ischemia in rats.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (12 results)

All 2005 2004 2003 Other

All Journal Article (7 results) Publications (5 results)

  • [Journal Article] An evaluation of white matter injury after spinal cord ischemia in rats2005

    • Author(s)
      Kurita N, Kawaguchi M, et al.
    • Journal Title

      Anesth Analg 100(3)

      Pages: 847-854

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An evaluation of white matter injury after spinal cord ischemia in rats : a comparison with gray matter injury.2005

    • Author(s)
      Kurita N, Kawaguchi M, Horiuchi T, Inoue S, Sakamoto T, Nakamura M, Konishi N, Furuya H.
    • Journal Title

      Anesth Analg 100(3)

      Pages: 847-854

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An Evaluation of white matter injury after spinal cord ischemia in rats2005

    • Author(s)
      Kurita N, Kawaguchi M, Horiuchi T, et al.
    • Journal Title

      Anesth Analg 100(3)(in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The effects of the delta-opioid agonist SNC80 on hind-limb motor function and neuronal injury 〜2004

    • Author(s)
      Horiuchi T, Kawaguchi M, et al.
    • Journal Title

      Anesth Analg 99(1)

      Pages: 235-240

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The effects of the delta-opioid agonist SNC80 on hind-limb motor function and neuronal injury after spinal cord ischemia in rats.2004

    • Author(s)
      Horiuchi T, Kawaguchi M, Sakamoto T, Kurita N, Inoue S, Nakamura M, Konishi N, Furuya H.
    • Journal Title

      Anesth Analg 99(1)

      Pages: 235-240

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The effects of the delta-opioid agonist SNC80 on hind-limb motor function and neuronal injury2004

    • Author(s)
      Horiuchi T, Kawaguchi M, Sakamoto T, et al.
    • Journal Title

      Anesth Analg 99(1)

      Pages: 235-240

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Long-term assessment of hind limb motor function and neuronal injury following spinal cord ischemia2003

    • Author(s)
      Sakamoto T, Kawaguchi M, Kurita N.et al.
    • Journal Title

      J Neurosurg Anesthesiol 15(2)

      Pages: 104-109

    • Related Report
      2004 Annual Research Report
  • [Publications] Kakimoto M., Kawaguchi M.et al.: "Evaluation of rapid ischemic preconditioning in a rabbit model of spinal cord ischemia"Anesthesiology. 99(5). 1112-1117 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakamoto T, Kawaguchi M, et al.: "Long-term assessment of hind limb motor function and neuronal injury following spinal cordischemia in rats"J Neurosurg Anesthesiol. 15(2). 104-109 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakamoto T, Kawaguchi H, Kurita N, et al.: "Long-ferw assessment of hind limb motor function and neuronal injury spinal cord ischemia in rats"Journal of Neurosurgnal Ares physiology. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawaguchi. et al.: "Isoflwrare delays but does not prevent cerebral infarction in rats subjected to focal lschemia"Anesthesiology. 92. 1335-1342 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] MASAHIKO KAWAGUCHI, PIYUSH M.PATEL: "Neuroprotection and Anesthetic Agents"Current Anesthesiology Reports. 2. 232-235 (2000)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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