| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Research Abstract |
We developed the system in which we could measure changes of pial artery diameter, and changes in cerebral blood fow in rats. By using this system, we found that acute fall in cerebral blood flow and diameter after subarachnoid hemorrhage (SAH) was prevented by the inhibitor of 20-HETE, 17-ODYA. We also found that the concentration of 20HETE was increased after SAH, and this increased level of 20-HETE was attenuated by the inhibitor. Furthermore, if we simultaneously block 20-HETE production and increased EETs levels by the another inhibitor, we could successfully reverse the acute fall of cerebral blood flow.
Therefore, from our study, it is suggested that the production of 20-HETE and may be the fall in EETs levels after SAH contributes to the acute fall in cerebral blood flow (acute cerebral vasospasm). Further, the inhibition of 20-HETE production and administration of EETS may give us therapeutic insights after SAH.
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