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An experimental study on hypotensive resuscitation of near-lethal uncontrolled hemorrhage : Effects on tissue dysoxia, mortality and end-organ function at 72 hours

Research Project

Project/Area Number 13671613
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHamamatsu University School of Medicine (2002)
Keio University (2001)

Principal Investigator

AOKI Katsunori  Hamamatsu University School of Medicine, Emergency Medicine, Professor, 医学部, 教授 (20124927)

Co-Investigator(Kenkyū-buntansha) NISHINA Masayoshi  Hamamatsu University School of Medicine, Emergency Medicine, Associate Professor, 医学部, 助教授 (20180622)
関根 和彦  慶應義塾大学, 医学部, 助手 (90296715)
並木 淳  慶應義塾大学, 医学部, 助手 (20189195)
相川 直樹  慶應義塾大学, 医学部, 教授 (40110879)
葉 季久雄  慶應義塾大学, 医学部, 助手 (00327644)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordshemorrhagic shock / experimental model / resuscitation / fluid replacement / tissue oxygen metabolism / acidosis / survival / hyperoxia / ショック / 出血モデル / 外傷 / 血栓 / トノメーター / 酸素代謝 / 臓器障害
Research Abstract

The purpose of this study was to evaluate tissue dysoxia, survival and incidence of end-organ injury, 3 days following normotensive and hypotensive resuscitation of uncontrolled hemorrhage. Fifteen canines (Beagle, BW 13〜16kg) were assigned to 3 groups : Groups A, B, and C were hemorrhaged to a mean pressure 40 mmHg in the presence of a 4-mm aortic tear : Group A (n=5) was resuscitated to a mean pressure 100 mmHg for 45 min ; Group B (n=5) was moderately under resuscitated to a mean pressure 60 mmHg for 45 min ; Group C (n=5) was moderately under resuscitated to a mean pressure 60 mmHg simultaneously with hyperoxia (PaO2=600 mmHg) for 45 min. After 45 min, the aortotomy was repaired, and animals were resuscitated baseline physiologic parameters. Gastric mucosal Pco_2, and arterial blood pH were significantly improved in Gr.C as compared to Gr.A and B during the 45 min of moderate under-resuscitation. By 72 h, physiologic parameters in surviving animals had returned to baseline levels. Seventy-two-hour mortality was 80%, 0%, and 0% for Group A through C. Measures of kidney, liver, and pulmonary function did not change from baseline. There was no histologic evidence of end-organ injury. In this model, 45 min of under-resuscitation did not result in end-organ injury. There was a trend toword greater survival, and tissue dysoxia was significantly prevented with hyperoxia with moderate under-resuscitation (mean pressure of 60 mmHg).

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Aoki K.: "Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns"Burns. 27. 569-575 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ng W.: "Characteristics of elderly patients presenting to the emergency department with injury"Keio J Med. 51. 11-16 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki M.: "Correlation between QT dispersion and burn severity"Burns. 28. 481-485 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura I.: "Cardiopulmonary arrest induced by anaphylactoid reaction with contrast media"Resuscitation. 53. 223-226 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yashino A.: "Enhanced secretion of tissue plasminogen activator by simultaneous use of retinoic acid and ascorbic acid from tissue cultured gastroepiploic artery"Life Sciences. 70. 1461-1470 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 青木克憲: "胃粘膜PrCO_2による多臓器不全の予知に関する検討"日本救命医療学会雑誌. 15. 53-59 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 相川直樹, 堀 進悟, 青木克憲: "救急データブック"中外医学社. 351 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Aoki, Katsunori: "Elevation of plasma free PAI-1 levels as an integrated endofhelial response to severe burns"Burns. 27. 569-575 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ng. Wang: "Characteristics of elderly patients presenting to the emergency department with injury"Keio J Med. 51. 11-16 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, Masaru: "Correlation between QT dispersion and burn severity"Burns. 28. 481-485 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura, Iwao: "Caridiopulmonary arrest induced by anaphylactoid reaction with contrast media"Resuscitation. 53. 223-226 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshino, Atsuto: "Enhanced secretion of tissue plasminogen activator by simultaneous use of retinoic acid and ascorbic acid from tissue cultured gastroepiploic artery"Life Science. 70. 1461-1470 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Aoki, Katsunori: "Validation of gastric mucosal PCO2 as a prognostic marker of multiple organ dysfunction syndrome"Jpn J Crit Care Med. 15. 53-59 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Aoki K.: "Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns"Burns. 27(6). 569-575 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ng W.: "Characteristics of elderly patients presenting to the emergency department with injury"Keio J Med. 51(1). 11-16 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuki M.: "Correlation between QT dispersion and burn severity"Burns. 28(4). 481-485 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakamura I.: "Caridiopulmonary arrest induced by anaphylactoid reaction with contrast media"Resuscitation. 53(2). 223-226 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshino A.: "Enhanced secretion of tissue plasminogen activator by simultaneous use of retinoic acid and ascorbic acid from tissue cultured gastroepiploic artery"Life Sciences. 70(8). 1461-1470 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 青木克憲: "胃粘膜PrCO2による多臓器不全の予知に関する検討"日本救命医療学会雑誌. 15(1). 53-59 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 相川直樹, 堀 進悟, 青木克憲: "救急データブック"中外医学社. 351 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Katsunori Aoki: "Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns"Burns. 27(6). 569-575 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 青木 克憲: "胃粘膜PrCO_2による多臓器不全の予知に関する検討"日本救命医療学会雑誌. 15(1). 53-59 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 青木 克憲: "ショック"外科と代謝・栄養. 35(1). 53-57 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 青木 克憲: "外傷とSIRS、CARS"医学のあゆみ. 196(1). 33-38 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 青木 克憲: "消化管粘膜pHモニタリング"救急医学. 25(7). 795-800 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 青木 克憲: "重症外傷・広範囲熱傷の栄養管理"静脈経腸栄養. 16(3). 3-7 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 相川直樹, 青木克憲: "救急データブック"中外医学社. 351 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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