| Project/Area Number |
13671614
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
KOTAKE Yoshifumi Keio University, School of Medicine, Assistant professor, 医学部, 講師 (70195733)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Yoshihisa Keio University, School of Medicine, Instructor, 医学部, 助手 (10276983)
TAKEDA Junzo Keio University, School of Medicine, Professor, 医学部, 教授 (30101968)
印南 靖志 慶應義塾大学, 医学部, 助手 (80296615)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | ischemia / reperfusion / preconditioning / liver / rabbit / inflammation / 静脈麻酔薬 / K ATP channel |
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| Research Abstract |
In this research project, the interaction between anesthetic agents as well as ATP-dependent potassium channel activation and protective effects caused by ischemic preconditioning in hepatosplanchnic organs. We established the partial hepatic ischemia-reperfusion model in anesthetized rabbits and determined the hepatic ischemia-reperfusion injury with microvascular blood flow and galactose clearance. First, we found that isoflurane, volatile anesthetic agent, offered stronger protection compared to intravenous anesthetic, propofol (Am Soc Anesthesiologists, annual meeting A-94, 2002). Second, activation of ATP-dependent potassium channel by nicorandil did not offer signiftcant protection in the liver ischemic injury (Am Soc Anesthesiologists, annual meeting A-721, 2003). These results are either under submission or during preparatory phase for future submission to the English academic journals. Furthermore, the interaction between preconditioning and suppression of neutrophil or Kupffer cell-dependent inflammatory process are under investigation.
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