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ISOLETION OF GENES RELATED TO HORMONE-REFRACTORY PROCESS OF PROSTATE CANCER AND GENETIC DIAGNOSIS

Research Project

Project/Area Number 13671635
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionCHIBA UNIVERSITY

Principal Investigator

SUZUKI Hiroyoshi  Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (60301818)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsprostate cancer / hormonal therapy / hormone-independency / androgen receptor / testosterone / p51 gene / neuroendocrine differentiation / chromogrnine A / 前平腺癌 / ホルモン依存性腫瘍 / 内分泌療法 / CD44 / KAI1 / retinoic acid receptor β / p51
Research Abstract

(1) Neuroendocrine differentiation (NED) is thought to be one of important mechanisms involved in hormone-refractory process in prostate cancer. I found that serum NED markers (i.e., chromogrnine A and neuro-specific enolase) could be prognostic markers for matastatic prostate cancer patients treated by hormonal therapy.
(2) I found that serum testosterone level and/or CAG polymorphic lengths of androgen receptor gene could be prognostic markers for matastatic prostate cancer patients treated by hormonal therapy.
(3) I investigated expression and structural abnormalities of p51 gene, a homologue of p53 tumor suppressor gene, and found that this gene is related to prostate cancer progression.
These results made clear hormone-refractory processes of prostate cancer. To clarify more detail of molecular mechanism of prostate cancer, further studies should be performed.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Akakura, K., Suzuki, H., et al.: "Possible mechanism of dexamethasone therapy for prostate cancer : Suppression of circulating levels of interleukin-6"Prostate. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nagata, M., Suzuki, H., et al.: "Paraplegia or quadriplesia due to metastatic spinal cord compression in prostate cancer"Prostate Cancer P. D.. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Xu, J., Suzuki, H., et al.: "Germline mutations of the Macrophage Scavenger Receptor 1 gene are associated with prostate cancer risk in Caucasian and African American men"Nature Genet.. 32. 321-325 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawana, Y., Suzuki, H., et al.: "Loss of heterogeneity at 7q31.1 and 12p13-12 in advanced prostate cancer"Prostate. 53. 60-64 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamachi, H., Suzuki, H., et al.: "Clinical significance of pulmonary metastases in stage D2 prostate cancer patients"Prostate Cancer P. D.. 5. 159-163 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, H., Akakura, K., et al.: "CAG polymorphic repeat lengths in androgen receptor gene among Japanese prostate cancar patients : Potential predictor of prognosis after endocrine therapy"Prostate. 51. 219-224 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi, H., Fukutome, K., Watanabe, M., Furusato, M., Shiraishi, T., Ito, H., Suzuki H., Ikawa, S., Hano, H.: "Mutation analysis of the p51 gene and correlation between p53, p73, and p51 expressions in prostate carcinoma"Prostate. 47. 85-90 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakayama, T., Watanabe, M., Yamanaka, M., Yoshifumi, H., Suzuki. H., Ito, H., Yatani, R., Shiraishi, T.: "The role of epigenetic modifications in retinoic acid receptor β2 gene expression in human prostate cancers"Lab. Invest.. 81. 1049-1057 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sekita, N., Suzuki. H., Ichikawa, T., Kito, H., Akakura, K., Igarashi, T., Nakayama, T., Watanabe, M., Shiraishi, T., Toyota, M., Yoshie, O., Ito, H.: "Epigenetic regulation of the KAI-1 metastasis suppressor gene in human prostate cancer cell lines"Jpn. J. Cancer Res.. 92. 947-951 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kito, H., Suzuki H., Ichikawa, T., Sekita, N., Kamiya, N., Akakura, N., Igarashi, T., Nakayama, N., Watanabe, M., Harigaya, K., Ito, H.: "Hypermethylation of the CD44 gene is associated with progression and metastasis of human prostate cancer"Prostate. 49. 110-115 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imamoto, T., Suzuki H.. Akakura, K., Komiya, A., Nakamachi, H., Ichikawa, T., Igarashi, T., Ito, H.: "Pretreatment serum level of testosterone as a prognostic factor in Japanese men with hormonally treated stage D2 prostate cancer"Endocr. J.. 48. 573-578 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Isshiki, S., Akakura, K., Komiya, A., Suzuki. H., Kamiya, N., Ito, H.: "Chromogranin A concentration as a serum marker to predict prognosis after endocrine therapy in prostate cancer"J. Urol.. 167. 512-515 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Filippova, G.N., Qi, C.F., Ulmer, J.E., Ward, M.D., Hu, Y.J., Loukinov, D.I., Pugacheva, E.M., Klenova, E.M., Gundy, P.E., Feinberg, A.P., Cleton-Jansen, A.M., Moerland, E.W., Cornelisse, C.J., Suzuki H., Komiya, A., Lindblom, A., Dorion-Bonnet, F., Neiman, P.E., Morse, H.C., Collins, S.J., Lobanenkov, V.V.: "Tumor-associated zinc-finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity"Cancer Res.. 62. 48-52 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, H., Akakura, K., Ueda, T., Mikami, K., Tobe, T, Komiya A., Ichikawa, T., Igarashi, T. and Ito, H.: "Clinical characteristics of prostate cancer in elderly Japanese patients 80 years of age or older"Eur. Urol.. 41. 172-177 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzuki, H., Akakura, K., Komiya, A., Ueda, T., Imamoto, T., Furuya, Y., Ichikawa, T., Watanabe, M., Shiraishi, T., Ito, H.: "CAG polymorphic repeat lengths in androgen receptor gene among Japanese prostate cancer patients : Potential predictor of prognosis after endocrine therapy"Prostate. 51. 219-224 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamachi, H., Suzuki, H., Akakura, K., Imamoto, T., Ueda, T., Ishihara, M., Furuya, F. and Ito, H.: "Clinical significance of pulmonary metastases in stage D2 prostate cancer patients"Prostate Cancer P. D.. 5. 159-163 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hamano, M., Kuramochi, H., Nihei, N., Kamiya, N., Suzuki, H., Igarashi, T., Barrett, J.C., Ichikawa, T., Ito, H.: "Mechanisms of metastasis suppression by introduction of human chromosome 10 into rat prostate cancer"Asian J. Androl.. 4. 123-129 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoki, S., Ota, S., Ichikawa, Y., Suzuki, H., Ueda, T., Naya, Y., Akakura, K., Igarashi, T., Oshimura, M., Nihei, N., Barrett, J.C., Ichikawa, T., Ito, H.: "Suppression of metastasis of rat prostate cancer by introduction of human chromosome 13"Asian J. Androl.. 4. 131-136 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawana, Y,, Ichikawa, T., Suzuki, H., Ueda, T., Komiya, A., Ichikawa, Y., Furuya, Y, Akakura. K., Igarashi, T., Ito, H.: "Loss of heterogeneity at 7q31.1 and 12p13-12 in advanced prostate cancer"Prostate. 53. 60-64 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Xu, J., Zheng, S.L., Komiya, A., Mychaleckyj, J., Isaacs, S.D., Faith, D.A., Hu, J.J., Sterling, D., Lange, E., Hawkins, G.A., Turner, A., Ewing, C.M., Johnson, J.R., Suzuki. H., Bujnovszky, P., Wiley, K.E., DeMarzo, A., Chang, B., Hall, M.C., McCullough, D.L., Partin, A.W., Kassabian, V.S., Carpten, J.D., Bailey-Wilson, J., Trent, J.M., Ohar, J., Bleecker, E.R., Walsh, P.C., Isaacs, W.B., Meyers, D.A.: "Germline mutations of the Macrophage Scavenger Receptor 1 gene are associated with prostate cancer risk in Caucasian and African American men"Nature Genet. 32. 321-325 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Akakura, K., Suzuki, H., et al.: "Possible mechanism of dexamethasone therapy for prostate cancer : Suppression of circulating levels of interleukin-6"Prostate. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagata, M., Suzuki, H., et al.: "Paraplegia or quadriplesia due to metastatic spinal cord compression in prostate cancer"Prostate Cancer P. D.. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Xu, J.,, Suzuki, H., et al.: "Germline mutations of the Macrophage Scavenger Receptor 1 gene are associated with prostate cancer risk in Caucasian and African American men"Nature Genet.. 32. 321-325 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawana, Y., Suzuki, H., et al.: "Loss of heterogeneity at 7q31.1 and 12p13-12 in advanced prostate cancer"Prostate. 53. 60-64 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakamachi, H., Suzuki, H., et al.: "Clinical significance of pulmonary metastases in stage D2 prostate cancer patients"Prostate Cancer P. D.. 5. 159-163 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuki, H., Akakura, K., et al.: "CAG polymorphic repeat lengths in androgen receptor gene among Japanese prostate cancer patients : Potential predictor of prognosis after endocrine therapy"Prostate. 51. 219-224 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi H, et al.: "Mutation analysis of the p51 gene and correlation between p53,p73,and p51 expressions in prostate carcinoma"The Prostate. 47. 85-90 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakayama T, et al.: "The role of epigenetic modifications in retinoic acid receptor β2 gene expression in human prostate cancers"Laboratory Investigation. 81. 1049-1057 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sekita N, et al.: "Epigenetic regulation of the KAI-1 metastasis suppressor gene in human prostate cancer cell lines"Japanese Journal of Cancer Research. 92. 947-951 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kito H, et al.: "Hypermethylation of the CD44 gene is associated with progression and metastasis of human prostate cancer"The Prostate. 49. 110-115 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Imamoto T, et al.: "Pretreatment serum level of testosterone as a prognostic factor in Japanese men with hormonally treated stage D2 prostate cancer"Endocrine Journal. 48. 573-578 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki H, et al.: "Clinical characteristics of prostate cancer in elderly Japanese patients 80 years of age or older"European Urology. (in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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