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Basic research of new modality for assessment of fetal condition using blood flow pattern in inferior vena cava

Research Project

Project/Area Number 13671711
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

KANZAKI Toru  Osaka University, Hospital, Associate professor, 医学部付属病院, 助教授 (00263278)

Co-Investigator(Kenkyū-buntansha) FUKUDA Hirotsugu  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40324751)
MURATA Yuji  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (40283759)
藤井 絵里子  大阪大学, 医学系研究科, 助手 (70231561)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsFetal cardiac failure / Fetal central venous pressure / Fetal IVC blood flow / 胎児下大静脈血液 / 下大静脈血流波形
Research Abstract

Objective : In the fetal hydrops hypoxemia or acidemia are not always present, but the fetal jeopardy resulting in the death actually exists. This is the reason why the assessment of fetal circulation is imperative to evaluate the fetal wellbeing. In the fetus cardiac impairment seems to be manifested by right heart failure, thus the investigation of venous circulation is particularly important. The purpose of this study is to elucidate the usefulness of inferior vena caval (IVC) blood flow measurement for the evaluation of the fetal wellbeing and to confirm the pathophysiology which influence the blood flow of IVC using animal model
Methods : The new index named preload index (PLI) was defined to evaluate the reverse flow of the IVC. Among several fetal diseases including IUGR, the PLI values were compared. In the chronically prepared pregnant sheep animal model, the effect of the transfusion on the fetus was studied
Results : The mean of PLI is almost constant after 24 gestational weeks and the cut off value is set at 0.4 throughout this period. The PLI value was high in the case of endometrial fibroelastosis of the heart with hydrops, which represents the typical fetal heart failure. In the IUGR the elevation of PLI indicated the poor neonatal outcome. In the animal model, the correlation between the fetal central venous pressure and the blood flow pattern was confirmed
Conclusion : The usefulness of the IVC blood flow analysis for the assessment of the fetal condition was confirmed

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Satoh S., T Kanzaki., et al.: "Chronologic change in Doppler indices in the umbilical and middle cerebral arteries in the Japanese fetus : JSUM standardization committee for fetal measurements."J Med Ultrasound. 9. 73-78 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mu J., Kanzaki T., Tomimatsu T., Fukuda H., Murata Y., et al.: "A comparative study of intraplacental villous arteries by latex cast model in vitro and color Doppler flow imaging in vivo."J Obstet Gynaecol Res. 27. 297-303 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mu J., Kanzaki T., Tomimatsu T., Fukuda H., Murata Y., et al.: "Investigation of intraplacental villous arteries by Doppler flow imaging in growth-restricted fetuses."Am J Obstet Gynecol. 186. 297-302 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kanagawa, T.Kanzaki, Y.Chiba: "Chronologic changes in the PLI value at the fetal inferior vena cava in the Japanese fetuses."J Med Ultrasound. 10. 94-98 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fuke S, Kanzaki T, Mu J, et al.: "Antenatal prediction of pulmonary hypoplasia by acceleration time/ejection time ratio of fetal pulmonary arteries by Doppler blood flow velocimetry."Am J Obstet Gynecol. 188. 228-233 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 神崎 徹: "下大静脈血流波形による胎児循環動態の評価"日本産科婦人科学会雑誌. 54. 1139-1151 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Satoh, Y.Fujita, H.Nakano, N.Akamatsu, Y.Chiba, T.Okai, M.Natri, T.Kanzaki, N.Shinozuka, H.Takeuchi: "Chronologic change in Doppler indices in the umbilical and middle cerebral arteries in the Japanese fetus : JSUM standardization committee for fetal measurements"J Med Ultrasound. 9. 73-78 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] J.Mu, T.Kanzaki, T.Tomimatsu, H.Fukuda, E.Fujii, S.Fuke, K.Wasada, H.Takeuchi, Y.Murata: "A comparative study of intraplacental vinous arteries by latex cast model in vitro and color Doppler flow imaging in vivo"J Obstet Gynaecol Res. 27. 297-303 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] J.Mu, T.Kanzaki, T.Tomimatsu, H.Fukuda, E.Fujii, H.Takeuchi, Y.Murata: "Investigation of intraplacental vinous arteries by Doppler flow imaging in growth restricted fetuses"Am J Obstet Gynecol. 186. 297-302 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kanagawa, T.Kanzaki, Y.Chiba: "Chronologic changes in the PLI value at the fetal inferior vena cava in the Japanese fetuses"J Med Ultrasound. 10. 94-98 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kanzaki: "Assessment of fetal hemodynamic condition using IVC blood flow pattern"Acta Obst Gynec JPN. 54. 1139-1151 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fuke S, Kanzaki T, Mu J, Wasada K, Takemura M, Mitsuda N, Murata Y.: "Antenatal prediction of pulmonary hypoplasia by acceleration time/ejection time ratio of fetal pulmonary arteries by Doppler blood flow velocimetry"Am J Obstet GyneCol.. 188. 228-233 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mu J., Kanzaki T., Tomimatu T., Fukuda H., Murata Y., et al.: "Investigation of intraplacental villous by Doppler flow imaging in growth restricted fetuses"Am J Obstet Gynecol. 186. 297-301 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mu J., Kanzaki T., Tomimatu T., Fukuda H., Murata Y., et al.: "A comparative study of intraplacental villous arteries by latex cast model in vitro and color Doppler flow imaging in vivo"J Obstet Gynaecol Res. 27. 297-303 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 神崎 徹: "下大静脈血液波形による胎児循環動態の評価"日本産婦人科雑誌. 54. 1139-1157 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M, J.Kanzaki, T.Tomimatsu, T.Fukuda, H.Fujii, E.Murata, Y: "Investigation of intraplacental villous arteries by Doppler flow imaging in growth-restricted fetuses"Am J Obstet Gynecol. 186. 297-302 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mu, J.Kanzaki, T.Tomimatsu, T.Fukuda, H.Fujii, E.Murata, Y: "A comparative study of intraplacental villous arteries by latex cast model in vitro and color Doppler flow imaging in vivo"J Obstet Gynecol Res. 27. 297-303 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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