| Project/Area Number |
13671713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
SHIMOYA Koichiro Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40291950)
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| Co-Investigator(Kenkyū-buntansha) |
ISAKA Shigeyuki Osaka University Graduate School of Medicine, Assiatant Professor, 医学系研究科, 助手 (50346201)
TAKEMURA Masahiko Osaka University Graduate School of Medicine, Assistant Professor, 医学部附属病院, 助手 (50294062)
KOYAMA Masayasu Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (00183351)
東 千尋 大阪大学, 医学部・附属病院, 助教授 (20151061)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | protease inhibitor / Fallopian tube / SLPI / acrosome reaction / fraclalkine / SLPI(secretory leukocyte elastase inhibitor) |
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| Research Abstract |
In the present study we examined the function of fractalkine in the reproductive area. Western blot analysis revealed the presence of fractalkine protein in the seminal plasma and the association between the fractalkine concentration of the seminal plasma and sperm mortality. We demonstrated the existence of fractalkine in the Fallopian tubes the localization of fractalkine in the epithelial cells of the Fallopian tubes. RT-PCR revealed the expression of fractalkine mRNA in the Fallopian tubes. We demonstrated the presence of CX3CR1 (fractalkine receptor) and the localization of CX3CR1 in the tails of the sperm. These results suggest that fractalkine in the Fallopian tube may have an important role in the sperm motion.
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