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Eradication of HPV post surgical treatments, its correlation with specific types, type of surgeries, and the physical status

Research Project

Project/Area Number 13671720
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

YOSHINOUCHI Mitsuo  OKAYAMA UNIVERSITY, Medical Hospital, Lecturer, 医学部附属病院, 講師 (50261235)

Co-Investigator(Kenkyū-buntansha) NAGAO Shoji  OKAYAMA UNIVERSITY, Medical Hospital, Assistant, 医学部附属病院, 助手 (70335602)
NASU Yasutomo  OKAYAMA UNIVERSITY, Medical Hospital, Lecturer, 医学部附属病院, 講師 (20237572)
KODAMA Junichi  OKAYAMA UNIVERSITY, Medical Hospital, Lecturer, 医学部附属病院, 講師 (90263582)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsHuman Papilloma Virus / cervical cancer / cervical dysplasia / physical slate / surgery / ヒトパピロース・ウイルス / 子宮頚癌
Research Abstract

Low-risk human papillomaviruses (HPVs) will be completely eradicated as long as most visible lesions are treated. However, it is uncertain whether this is also the case for high risk HPVs that are capable of causing cervical cancer. Many recent studies have demonstrated a high incidence of HPV persistence during post conization or loop electrosurgical excision (LEEP) due to high-grade cervical intraepithelial neoplasia (CIN). We correlated the postoperative HPV status with preoperative HPV types, types of surgeries, and HPV's physical status.
Postoperative HPV E6 amplification by nested PCR was carried out for 157 female patients with positive preoperative HPV. They underwent LEEPs, therapeutic laser conizations, and simple or radical hysterectomies. We found that high risk types of HPVs were eradicated in 42 out of 169 patients (26.4%) after extirpation of the lesions. The clearance rate of HPVs increased to 39.2% (40 of 102), excluding patients with other high risk (OHR) kinds of type 31, 52b, and 58, since OHR persisted after almost all surgeries. Eradication of HPV after radical hysterectomies are highly expected for patients with invasive cancer (70.0% when excluding OHR), while more than half of them with CIN continue to carry preoperative types of HPV or some different types from before treatment. Type 33 is most frequently persistent among types 16, 18, and 33. Persistent high risk HPVs increase the risk for recurrence post surgical treatments of CIN, but the incidence is not high as long as the lesion is completely removed.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] S.Nagao: "Rapid and sensitive detection of physical status of human papillomavirus type 16 DNA by quantitative real-time PCR."J.Clin.Microbiol.. 40(3). 863-867 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Kato: "Regression of esophageal papillomatous polyposis caused by high-risk type human papilloma virus."J.Gastroenterol.. 38(6). 579-583 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Yoshinouchi: "In vitro and in vivo growth suppression of human papillomavirus (HPV) 16-positive cervical cancer cells by E6 siRNA."Mol.Ther.. 8(5). 762-768 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] J.Fen: "Eradication of HPV post surgical treatments, its correlation with specific types, type of surgeries, and the physical status"Oncology Reports. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M Yoshinouchi: "RESEARCH ADVANCES IN MICROBIOLOGY The 3^<rd> ed."Global Research Network, Kerala, India. 174 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] J.Fen, M.Yoshinouchi, K.Nakamura, J.Kodama, Y.Nasu, K.Yamato, Y.Hiramatsu: "Eradication of HPV post surgical treatments, its correlation with specific types, type of surgeries, and the physical status."Oncology Reports. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Yoshinouchi, T.Yamada, M.Kizaki, J.Fen, T.Koseki, Y.Ikeda, T.Nishihara, K.Yamato: "In vitro and in vivo growth suppression of human papilloma virus (HPV) 16-positive cervical cancer cells by E6 siRNA."Mol.Ther.. 8(5). 762-768 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Kato, E.Orito, T.Yoshinouchi, R.Ueda, T.Koizumi, M.Yoshinouchi, M.Mizokami: "Regression of esophageal papillomatous polyposis caused by high-risk type human papilloma virus."J.Gastroenterol.. 38(6). 579-583 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Nagao, M.Yoshinouchi, Y.Miyagi, A.Hingo, J.Kodama, S.Itoh, T.Kudo: "Rapid and sensitive detection of physical status of human papillomavirus type 16 DNA by quantitative real-time PCR."J.Clin.Microbiol.. 40(3). 863-867 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Yoshinouchi, S.Nagao, J.Fen, A.Hongo, J.Kodama, K.Yamato: "Physical Status of Human Papillomavirus : Episomal, Integrated, or Concomitant?"RESEARCH ADVANCES IN MICROBIOLOGY The 3rd ed. (R.Mohan. eds.) (Global Research Network, Kerata, India). 51-65 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mitsuo Yoshinouchi: "Physical Status of Human Papillomavirus : Episomal, Integrated, or Concomitant?"RESEARCH ADVANCES IN MICROBIOLOGY. The 3^<rd> ed.. 51-65 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shoji Nagao: "Rapid and Sensitive Detection of Physical Status of Human Papillomavirus Type 16 DNA by Quantitative Real-Time PCR"Journal of Clinical Microbiology. 40(3). 863-867 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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