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POLYMORPHISMS ASSOCIATED WITH ENDOMETRIOSIS

Research Project

Project/Area Number 13671736
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKYOTO PREFECTURAL UNIVERSITY OF MEDICINE

Principal Investigator

KITAWAKI Jo  KYOTO PREF. UNIV . MED, MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (00204925)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsENDOMETRIOSIS / POLYMORPHISM / ESTROGEN RECEPTOR / AROMATASE / INTERLEUKIN-10 / HLA / 子宮内膜
Research Abstract

Endometriosis is defined by the presence of endometrial glands and stroma outside of the uterine cavity. Although its exact etiology and pathogenesis are unclear, the growth of endometriosis is estrogen-dependent. Studies have implied a role for genetic factors in the association between the development of endometriosis and genetic polymorphisms
A single nucleotide polymorphism in intron 1 of the ER-α gene and a 3-base pair insertion/deletion polymorphism in intron 4 of the CYP 19 gene encoding P450arom are associated with the susceptibility of endometriosis in a Japanese population
Interleukin-10 promoter polymorphisms were associated with the production of autoantibodies to carbonic anhydrase II in patients with endometriosis
Finally, we investigated the frequencies of HL-A-A, -B, -C and -DRB1 antigens or alleles in the patients with endometriosis and healthy control women. Significant positive association with endometriosis was observed for HLA-B7 and for Cw^*0702. Our results indicated that the HLA-A24-B^*0702-Cw^*0702-DRB1^*0101 haplotype was associated with endometriosis susceptibility

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Koshiba H. et al.: "Progesterone inhibition of functional leptin receptor mRNA expression in human endometrium"Molecular Human Reproduction. 7. 567-572 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kusuki I, et al.: "Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis"Europian Journal of Obstetrics and Gynecology and Reproductive Biology. 98. 114-118 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitawaki J et al.: "Genetic contribution of the interleukin-1Opromoter polymorphism in endometriosis susceptibility"American Journal of Reproductive Immunology. 47. 12-18 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kado N, et al.: "Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis In Japanese women"Human Reproduction. 17. 897-902 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitawaki J, et al.: "Association of HLA class I and class II alleles with susceptibility to endometriosis"Human Immunology. 63. 1033-1038 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishihara H, et al.: "Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from Women with endometriosis, adenomyosis, or leiomyomas"Fertility and Sterility. 79. 735-742 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koshiba H, et al: "Progesterone inhibition of functional leptin receptor Mrna expression in human endometrium"Molecular Human Reproduction. 7(6). 567-572 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kusuki I, et al: "Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis"Europian Journal of Obstetrics and Gynecology and Reproductive Biology. 98(1). 114-118 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitawaki J, et al: "Genetic contribution of the interleukin-10 promoter polymorphism in endometriosis susceptibility"American Journal of Reproductive Immunology. 47(1). 12-18 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kado N, et al: "Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women"Human Reproduction. 17(4). 897-902 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tatsumi H, et al: "Lack of stimulatory effect of dienogest on the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by endothelial cell as compared with other synthetic progestins"Maturias. 42(4). 287-294 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitawaki J, et al: "Association of HLA class I and class II alleles with susceptibility to endometriosis"Human lmmunology. 63(11). 1033-1038 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishihara H, et al: "Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in entopic endometrium from women with endometriosis, adenomyosis, or leiomyomas"Fertil Steril. 79(3 Suppl 1). 735-742 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kado N, et al.: "Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women"Human Reproduction. 17. 897-902 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 門 紀子 他: "子宮内膜症とIL-10の遺伝子多型との関連"エンドメトリオシース研究会会誌. 23. 107-110 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石原広章 他: "GnRHアゴニストとダナゾールの子宮内膜アロマターゼ発現抑制機序の違い"エンドメトリオーシス研究会会誌. 23. 111-114 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tatsumi H, et al.: "Lack of stimulatory effect of dienogest on the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by endothelial cell as compared with other synthetic progestins"Maturitas. 42. 287-294 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kitawaki J, et al.: "Association of HLA class I and class II alleles with susceptibility to endometriosis"Human Immunology. 63. 1033-1038 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishihara H, et al.: "Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas"Fertility and Sterility. 79. 735-742 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 北脇 城, 楠木 泉, 石原 広章, 小柴 寿人, 門 紀子, 塚本 克美, 本庄 英雄: "「子宮内膜症臨床診断法の向上への努力」-子宮内膜生検組織におけるアロマターゼの発現:子宮内膜症診断への応用"エンドメトリオーシス研究会会誌. 22. 72-76 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koshiba H, Kitawaki J, Ishihara H, Kado N, Kusuki I, Tsukamoto K, Honjo H.: "Progesterone inhibition of functional leptin receptor mRNA expression in human endometrium"Molecular Human Reproduction. 7(6). 567-572 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 門 紀子, 北脇 城, 石原 広章, 小柴 寿人, 楠木 泉, 塚本 克美, 本庄 英雄: "子宮内膜症、子宮腺筋症、および子宮筋腫とエストロゲン受容体αの遺伝子多型の関連"エンドメトリオーシス研究会会誌. 22. 181-184 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石原 広章, 北脇 城, 門 紀子, 楠木 泉, 小柴 寿人, 塚本 克美, 本庄 英雄: "GnRHアゴニストおよびダナゾール療法による子宮内膜アロマターゼ発現の抑制"エンドメトリオーシス研究会会誌. 22. 197-200 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kusuki I, Kitawaki J, Ishihara H, Koshiba H, Kado N, Ohshima K, Honjo H: "Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis"Europian Journal of Obstetrics and Gynecology and Reproductive Biology. 98(1). 114-118 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kitawaki J, Obayashi H, Ohta M, Kado N, Ishihara H, Koshiba H, Kusuki I, et al.: "Genetic contribution of the interleukin-10promoter polymorphism in endometriosis susceptibility"American Journal of Reproductive lmmunology. 47(1). 12-18 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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