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Studies on the Significance of Magnesium Metabolism in Physiological and Pathological Changes During Pregnancy

Research Project

Project/Area Number 13671738
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNara Medical University

Principal Investigator

MORIKAWA Hajime  Nara Medical University, School of Medicine, Professor, 医学部, 教授 (30030894)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Yoshiharu  Nara Medical University, School of Medicine, Assistant Professor, 医学部, 助手 (40291611)
KITANAKA Takashi  Nara Medical University, School of Medicine, Lecturer, 医学部, 講師 (10211195)
YAMASAKI Mineo  Nara Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (00220301)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2001: ¥3,100,000 (Direct Cost: ¥3,100,000)
KeywordsSerum total Mg / Ionized Mg in blood / Intracellular ionized Mg / Pregnancy / Menstrual cycle / Preeclampsia / Estradiol / Progesterone / 細胞内イオンMg / 卵胞ホルモン / 黄体ホルモン / 血小板
Research Abstract

I. Comparisons of magnesium metabolism in pregnant women with that in non-pregnant subjects revealed the following findings: l) serum total Mg levels in 2^<nd> and 3^<rd> trimester were significantly lower than those of non-pregnant women and in 1^<st> trimester of pregnancy, 2) ionized Mg levels in blood in 1^<st> trimester were significantly lower than those in non-pregnant women, followed by further declining in 2^<nd> and 3^<rd> trimester, 3) platelet intracellular Mg concentration in non-pregnant women in luteal phase was significantly higher than that in follicular phase. The value in 1^<st> trimester of pregnancy was still higher than that in luteal phase, although it significantly decreased in 2^<nd> and 3^<rd> trimester compared with that in 1^<st> trimester, 4) there was an inverse correlation between intracellular ionized Mg levels and ionized Mg in blood in non-pregnant women, while no such a relationship was observed in pregnant women. In vitro experiments revealed that es … More tradiol has an effect of reducing intracellular Mg ion and that progesterone has an effect of elevating that.
II. Comparisons of magnesium metabolism in preeclampsia with that in normal pregnancy revealed that 1) there were no differences in serum total Mg levels, 2) ionized Mg levels were significantly lower, 3) intracellular Mg levels were significantly lower, 4) either intracellular Mg levels of ionized Mg or its blood levels showed significant inverse correlation with mean blood pressure, 5) urinary output of Mg was significantly higher. In vitro experiments showed that PTH, Endothelin and serum obtained from patient with preeclampsia lowered the intracellular Mg concentration.
III. Experiments using rats revealed that there was a mechanism that augmented active absorption of calcium, a divalent cation just like Mg. In the duodenum during pregnancy, although there was no such a system for Mg. These results suggest that gestational hormonal changes bring altered Mg metabolism in pregnant subjects and that preeclampsia is affected with relative deficient state for Mg compared with normal pregnancy. This pathological state may be an important factor in maintaining the pathophysiology Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] S.Yoshida, H.Morikawa, et al.: "Study on the absorption site of divalent cations in the intestinal loop, using the multitracer technique"Riken Review. 35. 67-68 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Masuda, H.Morikawa, et al.: "Changes of sex steroids during the menstrual cycle and pregnancy alter the intracelluar free magnesium level"Trace Elem Electrol.. 20. 51-59 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森川 肇, 佐道俊幸: "妊婦の体重管理-栄養とビタミン"産婦人科の世界. 53. 611-621 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 山崎峰夫, 森川 肇他: "妊娠中毒症における電解質代謝の病態生理学的意義"日本妊娠中毒症学会雑誌. 9. 79-82 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 山崎峰夫: "妊娠時の血圧調整と電解質代謝動態"腎と透析. 51. 659-663 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森川 肇, 山崎峰夫他: "重症妊娠中毒症と血小板凝集能"産婦人科の世界. 53. 943-949 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 山崎峰夫: "妊娠中毒症の病態維持に影響を与える因子-Mgと妊娠中毒症-"産婦人科の実際. 51. 833-838 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森川 肇, 他: "母体合併症と救急医療-HELLP症候群-"産婦人科治療. 84. 924-928 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 山崎峰夫: "妊娠中毒症-予後の改善を目指して-臨床像:Terminationの基準"産科と婦人科. 69. 1751-1756 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 山崎峰夫: "妊娠中毒症の周産期管理-治療-"日本産婦人科学会雑誌. 55(掲載予定). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森川 肇, 山崎峰夫他: "新女性医学大系24「妊娠中毒症」"中山書店. 342 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森川 肇, 原田直哉他: "新女性医学大系2「妊娠・分娩・産褥の生理と異常」"中山書店. 382 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森川 肇, 山崎峰夫他: "新しい産科学"名古屋大学出版会. 283 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. Yoshida, M. Masuda, M. Nakayama, M. Yamasaki, H. Morikawa, R. Hirunuma, and S. Enomoto: "Study on the absorption site of divalent cations in the intestinal loop, using the multitracer technique"Riken Review. Vol. 35. 67-68 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Masuda, M. Yamasaki, H. Morikawa, S. Tohno, and Y. Tohno: "Changes of sex steroids during the menstrual cycle and pregnancy alter the intracellular free magnesium level"Trace Elm Electrol.. Vol. 20. 51-59 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Morikawa and T. Sadou: "Weight control in pregnant women - nutrition and vitamins - (in Jpaanese)"The World of Obstetrics and Gynecology. Vol. 53. 611-621 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Yamasaki, N. Furukawa, M. Masuda, S. Yoshida and H. Morikawa: "Pathophysiological roles of electrolytes metabolism in preeclampsia ( in Japanese)"J. Japan Society for the Study of Toxemia of Pregnancy. Vol. 9. 79-82 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Yamasaki: "The role of electrolytes metabolism in regulation of blood pressure during Pregnancy ( in Japanese)"Kidney and Dialysis. Vol. 51. 659-663 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Morikawa, R. Kawaguchi and M. Yamasaki: "Platelet aggregation in preeclampsia ( in Japanese)"The World of Obstetrics and Gynecology. Vol. 53. 943-949 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Yamasaki: "Magnesium metabolism in preeclampsia ( in Japanese)"Obstetrical and Gynecological Practice. Vol. 51. 833-838 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Morikawa, T. Sadou, H. Hirano, and H. Umekage: "HEELP syndrome ( in Japanese)"Obstetrical and Gynecological Therapy. Vol. 84. 924-928 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Yamasaki: "clinical considering: Criteria for termination of pregnancy ( in Japanese)"Obstetrics and Gynecology. Vol. 69. 1751-1756 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Yamasaki: "Management of preeclampsia - Therapeutic tactics - ( in Japanese)"ACTA OBSTETRICA ET GYNAECOLOGICA JAPONICA. Vol. 55 (9) (in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Morikawa, S. Yoshida, M. Yamasaki, et al.: "Comprehensive Handbook of Women's Medicine 24 "Preeclampsia" (in Japanese)"NAKAYAMA-SHOTEN. 342 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Morikawa, N. Harada, M. Yamasaki, et al.: "Comprehensive Handbook of Women's Medicine 2 (in Japanese), "Physiology and Pathophysiology in pregnancy ・partrition・ puerperium"NAKAYAMA-SHOTEN. 382 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Morikawa, M. Yamasaki, et al.: "New Concept of Obstetrics (in Japanese)"NAGOYA-DAIGAKU-SHUPPANKAI. 283 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Yoshida, H.Morikawa, et al.: "Study on the absorption site of divalent cations in the intestinal loop, using the multitracer technique"Riken Review. Vol.35. 67-68 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Masuda, H.Morikawa, et al.: "Changes of sex steroids during the menstrual cycle and pregnancy alter the intracellular free magnesium level"Trace Elem Electrol.. Vol.120. 51-59 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森川 肇, 佐道俊幸: "妊婦の体重管理-栄養とビタミン"産婦人科の世界. 53巻. 611-621 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山崎峰夫, 森川 肇 他: "妊娠中毒症における電解質代謝の病態生理学的意義"日本妊娠中毒症学会雑誌. 9巻. 79-82 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山崎峰夫: "妊娠時の血圧調節と電解質代謝動態"腎と透析. 51巻. 659-663 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森川 肇, 山崎峰夫 他: "重症妊娠中毒症と血小板凝集能"産婦人科の世界. 53巻. 943-949 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山崎峰夫: "妊娠中毒症の病態維持に影響を与える因子-Mgと妊娠中毒症-"産婦人科の実際. 51巻. 833-838 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森川 肇, 他: "母体合併症と救急医療-HELLP症候群-"産婦人科治療. 84巻. 924-928 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山崎峰夫: "妊娠中毒症-予後の改善を目指して-臨床像: Terminationの基準"産科と婦人科. 69巻. 1751-1756 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山崎峰夫: "妊娠中毒症の周産期管理-治療-"日本産科婦人科学会雑誌. 55巻(掲載予定). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森川 肇, 山崎峰夫, 他: "新女性医学大系24「妊娠中毒症」"中山書店. 342 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森川 肇, 原田直哉, 他: "新女性医学大系2「妊娠・分娩・産褥の生理と異常」"中山書店. 382 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森川肇, 山崎峰夫, 他: "新しい産科学"名古屋大学出版会. 283 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山崎峰夫, 古川直人, 桝田充彦, 吉田昭三, 森川肇: "妊娠中毒症における電解質代謝の病態生理学的意義"日本妊娠中毒症学会雑誌. 9巻・1号. 79-82 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山崎峰夫: "妊娠時の血圧調節と電解質代謝動態"腎と透析. 51巻・5号. 659-663 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 森川肇, 吉田昭三, 山崎峰夫: "病因と病態形成-カルシウム代謝異常"新女性医学大系24「妊娠中毒症」. 24巻. 102-108 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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