Restoration of function in the paralyzed laryngeal muscles by functional electrical stimulation

• Project/Area Number: 13671763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Asahikawa Medical College
• Principal Investigator: NONAKA Satoshi Otolaryngology-Head & Neck Surgery, Associate Professor, 医学部, 助教授 (50180758)
• Co-Investigator(Kenkyū-buntansha): KATADA Akihiro Otolaryngology-Head & Neck Surgery, Assistant, 医学部, 助手 (90281899)
• Project Period (FY): 2001 – 2002
• Project Status: Completed (Fiscal Year 2002)
• Budget Amount: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
• Keywords: Recurrent laryngeal nerve paralysis / Functional electrical stimulation / Restoration of laryngeal functions / Control of laryngeal movements / Atrophy of intrinsic laryngeal muscles / Decerebrate cats / Anesthetized rats / 内喉頭筋萎縮 / 組織学的検討 / 機能適電気刺激 / 最適刺激条件 / 吸気運動 / 発声運動

Research Abstract

Functional electrical stimulation (FES) has been debated as an innovative treatment in the management of patients with laryngeal paralysis. In this study, we examined whether FES to the paralyzed laryngeal adductor muscles improves the voice sounds impaired by unilateral laryngeal paralysis. We also examined whether FES is capable of preventing atrophy of the intrinsic laryngeal muscles cased by denervation of the recurrent laryngeal nerve (RLN). Our study indicates the possibility that FES to the paralyzed laryngeal adductor muscle is accepted as a new therapy for patients with unilateral laryngeal paralysis. Moreover, we confirmed that FES prevented atrophy of the paralyzed intrinsic laryngeal muscle. These results suggest the possibility that FES can reduce the impairment in laryngeal function induced by recurrent laryngeal nerve palsy.

Research Products

• [Publications] 片田彰博, 野中 聡, 他: "脱神経後の内喉頭筋萎縮に対する機能的電気刺激の効果"日本気管食道科学会会報. 54(印刷中). (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] A.Katada, S.Nonaka, et al.: "Restoration of function in the paralyzed laryngeal muscles by functional electrical stimulation in cats"International Congress Series 2444. (in press). (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] I.Kunibe, S.Nonaka: "The neuronal circuit of augmenting effects on intrisic laryngeal muscle activities induced by nasal air-jet stimulation in decerebrate cats"Brain Res.. (in press). (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Akihiro Katada, Satoshi Nonaka, Isamu Kunibe, Masaaki Adachi, Hiroshi Shigyo, Masanobu Imada, Tatsuya Hayashi, Yasuaki Harabuchi: "The effects of functional electrical stimulation on intrinsic laryngeal muscle atrophy after denervation"J. Jpn. Bronchoesophagol. Soc.. 54 (in press). (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Akihiro Katada, Satoshi Nonaka, Isamu Kunibe, Masanobu Imada, Tatsuya Hayashi, Yasuaki Harabuchi: "Restoration of function in the paralyzed laryngeal muscles by functional electrical stimulation in cats"International congress Series. 2444 (in press). (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Isamu Kunibe, Satoshi Nonaka, Akihiro Katada, Masaaki Adachi, Kei-ichi Enomoto, Yasuaki Harabuchi: "The neuronal circuit of augmenting effects on intrinsic laryngeal muscle activities induced by nasal air-jet stimulation in decerebrate cats"Brain Research. (in press). (2003)
  • Description: 「研究成果報告書概要(欧文)」より