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Study of the cyclic ADP-ribose signal system in the olfactory pathway

Research Project

Project/Area Number 13671773
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

MIWA Takaki  Kanazawa University, Graduate School of medical Sciences, Associate Professor, 大学院・医学系研究科, 助教授 (20229909)

Co-Investigator(Kenkyū-buntansha) KARASAWA Tadahiro  Kanazawa University, Graduate School of medical Sciences, Associate Professor, 大学院・医学系研究科, 助教授 (90251917)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordscyclic ADP-ribose / Olfactory pathway / signal transduction / olfactory receptor cell / mouse / セカンドメッセンジヤー
Research Abstract

It has been believed that olfactory transduction is mediated by two intracellular pathways, cAMP and IP3-pathways. These pathways are mediated by G-coupled protein. Recent studies have indicated that cyclic ADP-ribose (cADPR) related with signal systems in both insulin secretion from pancreas and signal transduction in Purkinje's cells of cerebellum. It is the purpose of this research to make inquiries into the relation of cADPR with signal transduction in olfactory receptor cells. To resolve this, we investigated them using olfactory epithelium of mouse by molecular biological technique. Cyclic AMP and cADPR concentrations of the extract from olfactory cilia fragments were measured by modified calcium shock method, to which evaluate in an instant of olfactory stimulation, but no remarkable changes were gained. The ligand binding of olfactory molecule to its receptor is vanished in an instant. More ingenious experiment system are needed to measure the instantaneous response in olfactory system.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Miwa T et al.: "Role of nerve growth factor in the olfactory epithelium"Microscopy Research and Technique. 58. 197-203 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 三輪高喜: "嗅覚障害の診断 現状と展望"日本味と匂学会誌. 10. 59-66 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 三輪高喜: "アロマサイエンスシリーズ21 ニオイの受容"フレグランスジャーナル. 272 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] TAKAKI MIWA: "Role of nerve growth factor in the olfact ory epithelium"Microscopy Research and Technique. 58. 197-203 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] TAKAKI MIWA: "The diagnosis of olfactory disturbance in Japan"The Japanese Journal of Taste and Smell Research. 10, 1. 59-66 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miwa T: "Role of nerve growth factor in the olfactory epithelium"Microscopy Research and Technique. 5. 197-203 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 三輪高喜: "嗅覚障害の診断展望と現状"日本味と匂学会誌. 10・1. 59-66 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 三輸高喜: "アロマサイエンスシリーズ21 においの受容"渋谷達明, 外池光雄. 272 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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