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Microsatellite Instability of Head and Neck Cancer and Field Cancerization

Research Project

Project/Area Number 13671803
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionTokai University

Principal Investigator

OKAMI Kenji  Tokai University, School of Medicine, Associate Professor, 医学部, 助教授 (90223734)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordshead and neck cancer / microsaellite instability / saliva / methylation / p16 tumor suppressor gene / 頭頚部癌
Research Abstract

A key to improve the prognosis of head and neck cancers is an early diagnosis of the disease. No screening method to detect these cancers has been developed yet. Molecular techniques using polymerase chain reaction are a sensitive method to detect a small population of cancer cells among normal cells. We conducted a series of microsatellite analysis to detect cancer cells in saliva from 23 oral and pharyngeal cancer patients. Eight microsatellite markers were selected to test for microsatellite instability (MSI) in the tumor and saliva samples. Of 23 samples, 5 (22%) had MSI in the tumor samples. No correlation between MSI and clinicopathological feature was identified. In 4 of 5 (80%) MSI positive samples, we detected the identical MSI in saliva. The possibility of the molecular screening and molecular follow-up is discussed.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Okami K, et al.: "Molecular detection of cancer cells in saliva from oral and pharyngeal cancer patients"The Tokai Journal of Experimental and Clinical Medicine. 27(3)(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okami K, Imate Y, Hashimoto Y, Kamada T, and Takahashi M.: "Molecular detection of cancer cells in saliva from oral and pharyngeal cancer patients"Tokai J Exp Clin Med. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okami K, et al.: "Molecular detection of cancer cells in saliva from oral and pharyngeal cancer patients"The Tokai Journal of Experimental and Clinical Medicine. 27・3(in press). (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2017-09-15  

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