| Project/Area Number |
13671821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gunma University |
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Principal Investigator |
IIDA Tomohiro Gunma University, Ophthalmology, associate professor, 医学部, 助教授 (50241881)
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| Co-Investigator(Kenkyū-buntansha) |
KANDA Tsugiyasu Kanazawa Medical University, Professor, 医学部, 教授 (40261838)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | choroidal neovascularization / BTEB2 / age-ralated macular degeneration / idiopathic choroidal neovascularization / smooth muscle / transcription factor |
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| Research Abstract |
We carried out an immunohistochemical investigation of the choroidal neovascular membranes from 12 eyes surgically excised because of age-related macular degeneration (n = 6) or idiopathic choroidal neovascularization (n = 6). Immunohistochemical staining was performed with antibodies specific for basic transcriptional element binding protein-2, actin or smooth muscle cell 1. In all membranes, the endothelial cells and stromal components around the vessels were immunoreactive for expression of basic transcriptlonal element binding protein-2, while immunoreactive expression of actin and smooth muscle cell type 1 was found in the surrounding stromal cells. These results suggest that basic transcriptional element binding protein-2, a zinc finger transcription factor, may contribute to establishment of the choroidal neovascularization observed in the pathogenesis of age-related macular degeneration and idiopathic choroidal neovascularization.
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