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Effect of ions on in vitro mineral induction by dentin matrix

Research Project

Project/Area Number 13672007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

TOYOOKA Hiroki  Health Sciences University of Hokkaido, School of Dentistry, Department of Operative Dentistry and Endodontology, Instructor, 歯学部, 助手 (30285530)

Co-Investigator(Kenkyū-buntansha) SAITO Takashi  Health Sciences University of Hokkaido, School of Dentistry, Department of Operative Dentistry and Endodontology, Assistant Professor, 歯学部, 講師 (40265070)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsdentin / mineral induction / ion
Research Abstract

The effect of ions that could be released from restorative materials on the mineralization of dentin are not known. Restorative material contains fluoride, silicate, calcium, phosphate, and sometimes magnesium, and silver at well. We examined the effects of various ions on mineralization of dentin matrix in vitro. Demineralized dentin matrix was incubated in metastable calsium phosphate solution with or without silicate, fluoride, calcium, phosphate, magnesium or silver. In soluble dentin matrix induced mineral fomation in metastable solution without added ions. Silicate and fluoride significantly reduced mineral induction by insoluble dentin matrix. At least calcium or phosphate was required to promote mineral induction. Conversely, magnesium and silver inhibited mineral induction. The mineral induced by each sample after incubation for 24h was identified by its X-ray diffraction pattern as apatite. We conclude that silicate is a stronger inducer of remineralization of dentin matrix than fluoride, calcium or phosphate, and that magnesium and silver inhibit the induction of mineralization of dentin matrix.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 豊岡広起: "リンタンパク質によるin vitro石灰化誘導実験-石灰化誘導におけるpHの変化-"日本歯科保存学雑誌. 第44巻・秋期特別号. 169 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 伊藤修一: "リンタンパク質によるin vitro石灰化誘導実験-誘導された石灰化物の解析-"日本歯科保存学雑誌. 第44巻・秋期特別号. 170 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 森清裕士: "Phosphophorynの組織工学への応用に関する基礎実験-培養ラット骨髄細胞に対するPhosphophorynの作用-"日本歯科保存学雑誌. 第44巻・秋期特別号. 73 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroki TOYOOKA et al: "In vitro mineral induction by phosphoprotein - Changing of pH in mineral induction -"The Japanese Journal of Consavative Dentistry. Vol. 44, Autumn issue. 169 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shuichi ITO et al.: "In vitro mineral induction by phosphoprotein - Mineralogical analysis -"The Japanese Journal of Consavative Dentistry. Vol. 44, Autumn issue. 170 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi MORIKIYO et al.: "Fundamental experiment on application of phosphophorin to tissue engineering - Effect of phosphophorin on differentiation of bone narrow cell -"The Japanese Journal of Consavative Dentistry. Vol. 44, Autumn issue. 73 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 豊岡広起: "リンタンパク質によるin vitro石灰化誘導実験 -石灰化誘導におけるpHの変化-"日本歯科保存学雑誌. 第44巻・秋期特別号. 169 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 伊藤修一: "リンタンパク質によるin vitro石灰化誘導実験 -誘導された石灰化物の解析-"日本歯科保存学雑誌. 第44巻・秋期特別号. 170 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森清裕士: "Phosphophorynの組織工学への応用に関する基礎実験 -培養ラット骨髄細胞に対するPhosphophorynの作用-"日本歯科保存学雑誌. 第44巻・秋期特別号. 73 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 豊岡広起: "リンタンパク質によるin vitro石灰化誘導実験 -石灰化誘導におけるpHの変化-"日本歯科保存学雑誌. 第44巻・秋期特別号. 169 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 伊藤修一: "リンタンパク質によるin vitro石灰化誘導実験 -誘導された石灰化物の解析-"日本歯科保存学雑誌. 第44巻・秋期特別号. 170 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 森清裕士: "Phosphophorynの組織工学への応用に関する基礎実験 -培養ラット骨髄細胞に対するPhosphophorynの作用-"日本歯科保存学雑誌. 第44巻・秋期特別号. 73 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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