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Drug Interactions between Sedatives and Analgesics in Rat Cerebral Cortical Synaptoneurosomes, Phospholipids Model Membrane, and Autonomic Nervous Activity

Research Project

Project/Area Number 13672116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

KUDO Masaru  HEALTH SCIENCES UNIVERSITY OF HOKKAIDO, SCHOOL OF DENTISTRY, ASSISTANT PROFESSOR, 歯学部, 講師 (90244863)

Co-Investigator(Kenkyū-buntansha) ODA Kazuaki  HEALTH SCIENCES UNIVERSITY OF HOKKAIDO, SCHOOL OF PHARMACY, ASSOCIATE PROFESSOR, 薬学部, 助教授 (80094829)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordssedative and analgesic / Conscious Sedation / Prolonged sedated state / Postoperative nausea and vomiting / Anxiety / Pain / GABAA receptor complex / 鎮痛剤 / 鎮静剤 / 薬剤相互作用 / 運動機能低下 / GABA_Aレセプター / リン脂質二重膜
Research Abstract

Presently, we conducted the following general studies using the electroencephalogram and( electrocardiogram real time analysis through observation of the degree of stress and tension in patients, behavioral observation by introducing a behavioral pharmacological observation apparatus, test tubes binding experiments using radioisotopes, quantitative analysis of hormone excretions, with analysis of isatine which is an endogenous nerve active substance having broad biological activities using proton-NMR.
・The results of the electroencephalogram revealed that the electroencephalogram component: n-wave (13-30Hz) component increased when both pentazocine and midazolam were given together and extended the sedative state.
・Sympathetic nerve activities increased with pentazocine, while midazolam decreased these activities. Therefore, the effects of pentazocine and midazolam on the sympathetic nerves were found to be directly opposite actions.
・Parasympathetic nerve activities increased with pentaz … More ocine, but decreased with midazolam.
・With injection of an epinephrine-added local anesthetic solution to the oral mucous membrane, the epinephrine level in the adrenal veins decreased, but the epinephrine level increased in the femoral artery.
・We found no effects from administration of either analgesics or sedatives in terms of anxiety two hours after sedation was completed.
・Nausea, vomiting and dizziness after sedation were exacerbated by administering analgesics.
・We could not find a suitable method of administering both sedatives and analgesics to minimize the side effects of both agents.
・We developed and synthesized thiazole-coumarin derivatives: 3-(4-chloromethylthiazole-2-y)-7-dimethyl-aminochromen--2-one and 3-(5-acetyl-4-methylthiazole-2-yl)-7-diethylaminochromen-2one, fluorescent derivative forming agents against isatine for high performance liquid chromatography which are applicable as fluorescent derivative forming agents for HPLS when analyzing biological functions and biokinetics.
In the future, we would like to concentrate our studies in behavioral observations which can be applied to clinical studies, and to promote collaborative studies combining experiments using the electroencephalogram and electrocardiogram real time analysis with biochemical experiments, in an attempt to contribute our efforts to provide "successful operations, treatments and routine operation management with adequate safety under optimal conditions for both patients and medical care providers in the field of dentistry." Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 工藤 勝: "歯科における亜酸化窒素・酸素吸入鎮静法の有効性-痛くない,安心・快適な歯科医療を目指した笑気吸入鎮静法の有効利用-"Medical Gases. 5・1. 21-27 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masaru KUDO, et al.: "Positive correlation between the face anxiety scale and the state anxiety inventory in elderly Dental patients"HIGASHI NIPPON DENTAL JOURNAL. 22・1. 29-33 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naozumi Nichizono, et al.: "A novel method for the synthesis of 4'-thiopyrimidine nucleoside using hypervalent iodine compounds"Organic biomolecular Chemistry. 1. 3692-3697 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naozumi Nishizono, Kazuaki Oda, Yutaka Kato, et al.: "Reaction of Inatin 3-aryl-7-diethylamino-coumarins and their Fluore scent Properties"Heterocycles. 63・5. 1083-1091 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 河合拓郎, 工藤勝, 大桶華子, その他: "異常絞扼反射患者の脳波・心電リアルタイム解析システムを用いた歯科治療時の鎮静維持"日本歯科麻酔学会雑誌. 30・2. 248-249 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Kudo, H.Ohke, T.Kawai, et al.: "The Relationship Between trait Anxiety and Pain Sensation : Anxiety and Pain levels at puncture and Cannulation in High-Anxiety-State Volunteers"Anesth Prog. 48. 97-98 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] KUDO MASARU: "Efficacy of nitrous oxide/oxygen inhalation sedation dentistry-providing painless, safe, and comfortable dental treatment-"Medical Gas. 5(1). 21-27 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masaru KUDO, Flanako Ohke, Noboru Shinya: "Positive correlation between the face anxiety scale and the state anxiety inventory in elderly Dental patients"HIGASHI NIPPON DENTAL JOURNAL. 22(1). 29-33 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naozumi Nichizono, Ryosuke Baba, Chika Nakaimura, Kazuaki Oda, Minoru Machida: "A novel method for the synthesis of 4'-thiopyrimidine nucleoside using hypervalent iodine compounds"Organic biomolecular Chemistry. 1. 3692-3697 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naozumi Nishizono, Kazuaki Oda, Yutaka Kato, Kosei Ohno, Masaru Minami, Minoru Machida: "Reaction of Isatin 3-aryl-7-diethylamino-coumarins and their Fluorescent Properties"Heterocycles. 63(5). 1083-1091 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] TAKURO KAWAI, KIJDO MASARU, HANAKO OHKE, et al.: "Electroencephalogram and Electrocardiogram Real Time Analysis Measures Sedation for Gagging Patient during Dental Treatment"Journal of Japanese Dental Society of Anesthesiology. 30(2). 248-249 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Kudo, H.Ohke, T.Kawai, et al.: "The Relationship Between trait Anxiety and Pain Sensation: Anxiety and Pain levels at puncture and Cannulation in High-Anxiety-State Volunteers"Anesth Prog. 48. 97-98 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Kudo, H.Ohke, T.Kawai, et al.: "Effects of thinnerdental disposable injection needle and nitrous oxide inhalation sedation on pain relief in the puncture of the oral mucosa"HIGASHI NIPPON DENTAL JOURNAL. 21(2). 261-266 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masalu KUDO, et al.: "Positive correlation between the face anxiety scale and the state anxiety inventory in elderly Dental patients"HIGASHI NIPPON DENTAL JOURNAL. 22・1. 29-33 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 工藤 勝: "歯科における亜酸化窒素・酸素吸入鎮静法の有効性-痛くない,安心・快適な歯科医療を目指した笑気吸入鎮静法の有効利用-鎮静法の-"Medical Gases. 5・1. 21-27 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 工藤 勝, 他: "歯肉粘膜下浸潤麻酔時の注入圧と注射時間が不安と痛みに及ぼす影響"日本歯科麻酔学会雑誌. 32・1. 49-54 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naozumi Nichizono, Kazuaki Oda, et al.: "A novel method for the synthesis of 4'-thiopyrimidine nucleoside using hypervalent iodine compounds"Organic Biomolecular Chemistry. 1. 3692-3697 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naozumi Nishizono, Kazuaki Oda, Yutaka Kato, et al.: "Reaction of Inatin 3-aryl-7-diethylamino-coumarins and their Fluorescent Properties"Heterocycles. 63(5). 1083-1091 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 河合拓郎, 工藤 勝, 他: "研究異常絞扼反射患者の脳波・心電リアルタイム解析システムを用いた歯科治療時の鎮静維持"日本歯科麻酔学雑誌. 30・2. 248-249 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 工藤 勝, 他: "静脈路確保に伴う痛み・不安・成功率について"東日本歯学雑誌. 21・1. 127-136 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大桶 華子, 工藤 勝, 他: "極細歯科用ディスポーザブル注射針と笑気吸入鎮静法が口腔粘膜刺入の疼痛緩和に及ぼす影響"東日本歯学雑誌. 21・2. 261-266 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 工藤 勝: "不快と不安を与える歯科用局所麻酔注射針の視覚要因に関する"東日本歯学雑誌. 21・1. 75-80 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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