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Expression of Connexin 26 (Cx26) in oral squamous cell carcinoma

Research Project

Project/Area Number 13672118
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionDokkuo University School of Medicine

Principal Investigator

IMAI Yutaka  Dokkyo University School of Medicine, Professor, 医学部, 教授 (80114239)

Co-Investigator(Kenkyū-buntansha) SASAKI Tadaaki  Dokkyo University School of Medicine, Instructor, 医学部, 講師 (40225876)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsOral squamous cell carcinoma / Connexin 26 gene / Invasion / metastasis / ギャップ結合 / コネキシン26遺伝子 / 転移
Research Abstract

Connexins are a family of at least 12 proteins that make up intercellular channels of gap junction. Connexin 26 (Cx26) is one of those subtypes, and it is indicated to become an index to the cancer metastasis. However, there have been no reports of the role of this gene in oral cancer.
The present study was undertaken in order to investigate the expression of the Cx26 gene in oral squamous cell carcinoma (oral SCC). The relationship between these genes and clinico-pathological factors and the applicability of Cx26 as an index of cancer metastasis in oral SCC was also investigated.
The results of this study suggested that Cx26 gene expressions may be associated with metastasis of oral SCC, and the expression of this gene may interact with mesenchymal tissue. Clinically, Cx26 gene expression may be useful approach in obtaining information concerning the metastasis of oral SCC cells.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Imai Y, Narikawa K, Fujita Y, Akimoto K, Fujibayashi T: "Expression of connexin 26 gene in oral squamous cell arcinoma and itsclinico-pathological significant"Cranio-Maxillofacial Surgery. 30. 285-285 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imai Y, Narikawa K, Akimoto K, Fujibayashi T: "Expression of connexin 26 gene in oral squamous cell carcinoma and its clinico-pathological significant"Cranio-Maxillofacial Surgery. 30. 285-285

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imai Y, Narikawa K, Fujita Y, Akimoto K, Fujibayashi T: "Expression of connexin 26 gene in oral squamous cell carcinoma and its clinico-pathological significant"J. Cranio-Maxillofacial Surgery. 30. 285 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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