| Project/Area Number |
13672127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
USHAKU Lee Kanagawa Dental College, Oral Surgery, Assistant, 歯学部, 助手 (90288085)
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| Co-Investigator(Kenkyū-buntansha) |
OHMI Yasushi Kanagawa Dental College, Oral Surgery, Assistant, 歯学部, 助手 (10318892)
MATSUMOTO Goichi Kanagawa Dental College, Oral Surgery, Instructor, 歯学部, 講師 (60199867)
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| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Angiostatin / Oral Cancer / Gene Therapy / Angiogenesis / アンジオスタチン / 扁平上皮癌 / 遺伝子治療 |
|---|
| Research Abstract |
Antiangiogenic tumor therapies have recently attracted intense interest because of their direct endothelial targeting and the absence of drug resistance. To achieve tumor regression and tumor dormancy, antiangiogenic agents need to be administered. Local antiangiogenic gene therapy for cancer offers a potential way to achieve sustained therapeutic release of antiangiogenic substances. As a step toward this goal, we used liposomes complexed to angiostatin cDNA and targeted to human squamous cell carcinoma cell lines in vivo. Tumor cells expressing angiostatin after local gene transfer showed markedly reduced vascularity and contained many apoptotic tumor cells. These results demonstrate the potential utility of liposome-derived angiostatin for adjuvant therapy of oral cancer in humans.
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