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Metabolic activation of endocrine-disruptors in animal body

Research Project

Project/Area Number 13672343
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

KITAMURA Shigeyuki  Hiroshima University Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (40136057)

Co-Investigator(Kenkyū-buntansha) OHTA Shigeru  Hiroshima University Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (60160503)
WATANABE Hiromitsu  Hiroshima University Research Institute for Radiation Biology and Medicine, Professor, 原爆放射線医科学研究所, 教授 (00034653)
FUJIMOTO Nariaki  Hiroshima University Research Institute for Radiation Biology and Medicine, Associate Professor, 原爆放射線医科学研究所, 助教授 (40243612)
SUGIHARA Kazumi  Hiroshima University, Faculty of Medicine, Teaching Associate, 医学部, 教務員 (20271067)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsEstrogen / Antiandrogen / Thyroid hormonal compound / Vitellogenin / Endocrine disruptor / Drug metabolizing enzyme / Metabolic activation / Environmental pollutant / 内分泌撹乱前駆物質 / 甲状腺ホルモン撹乱物質
Research Abstract

The metabolic activation of endocrine disrupters was examined in this study.
1. Estrogenic activity was estimated by the reporter assay using human breast cancer cell line MCF-7. We found some proestrogens which were not estrogenic and produced their activities after the incubation with liver microsomes in the presence of NADPH. As proestrogens, we detected 2-nitrofluorene, trans-stilbene, biphenyl, diphenylmethane, dibenzyl, 2, 2-diphenylpropane, benzylideneacetone, styrene oligomers, diphenylamine, diphenylsulfone, azobenzene, pyrene, permethrin, dimethylphthalate and chalchone by screening the estrogenic activities of their metabolites. These proestrogens were converted to their hydroxylated active metabolites in vivo and in vitro in rats. The hydroxylation was mediated by liver microsomal cytochrome P450 2B1 or 1A1. 2. Bisphenol A, fluorene, pyrene, DDTs and some organophosphorus insecticides exhibited antiandrogenic activity. Fenthion sulfoxide also exhibited the activity after incubation with rat liver preparations. 3. Tetrabromobisphenol A, a flame retardant, exhibited thyroid hormonal activity. Some PCBs also exhibited the activity after the hydroxylation by cytochrome P450 system. 4. Trans-Stilbene, 2-nitrofluorene and fenthion showed endocrine-disrupting actions in vivo in rats. 5. When male goldfish were kept in the water containing trans-stilbene, diphenyl or 2-nitrofluorene (5x10^<-6> M) for five days, the vitellogenin level in blood was markedly increased. These hydroxylated compounds were detected in keeping water. These facts suggest that these proestrogens were activated to estrogens in mammals and fish.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (69 results)

All Other

All Publications (69 results)

  • [Publications] Koji Takekawa: "Enzymatic and Nonenzymatic Reduction of Brucine N-Oxide by Aldehyde Oxidase and Catalase"Xenobiotica. 31(11). 769-782 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shigeyuki Kitamura: "Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver"Biological and Pharmaceutical Bulletin. 24(7). 856-859 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazumi Sugihara: "Aryl Hydrocarbon Receptor (AhR)-Mediated Induction of Xanthine Oxidase/Xanthine Dehydrogenase Activity by 2,3,7,8-Tetrachloro-dibenzo-p-dioxin"Biochemical and Biophysical Research Communications. 281(5). 1093-1099 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, an Environmental Pollutant, and 2-Acetylaminofluorene in Fish"Bulletin of Environmental Contamination and Toxicology. 31(1). 371-378 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, 2-Aminofluorene and 2-Acetylaminofluorene in Rat and Dog and the Role of Intestinal Bacteria"Xenobiotica. 31(1). 33-49 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koji Takekawa: "Nonenzymatic Reduction of Aliphatic Tertiary Amine N-Oxides Mediate by the Heme Moiety of Cytochrome P450"Xenobiotica. 31(1). 11-23 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Osamu Ueda: "Deacylation of N-Arylformides and N-Arylacetamides by Formamidase in Rat Liver Drug Metabolism and Disposition"Drug Metabolism and Disposition. 31(12). 1297-1299 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shigeyuki Kitamura: "Thyroid Hormonal Activity of the Flame Retardants Tetrabromobisphenol A and Tetrachlorobisphenol A"Biochemical and Biophysical Research Communications. 293(1). 554-559 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, an Environmental Pollutant, by Liver Preparations of Sea Bream, Pagrus major"Xenobiotica. 32(8). 667-682 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shigeyuki Kitamura: "Reductive Metabolism of α,β-Ketoalkyne, 4-Phenyl-3-butyn-2-one, by Rat Liver Preparations"Drug Metabolism and Disposition. 30(4). 414-420 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Seigo Sanoh: "Cytochrome P450 1A1/2 Mediated Metabolism of trans-Stilbene in Rats and Humans"Biological and Pharmaceutical Bulletin. 25(3). 397-400 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shigeyuki Kitamura: "Reductive Metabolism of p,p'-DDT and o,p'-DDT by Rat Liver Cytochrome P450"Drug Metabolism and Disposition. 30(2). 113-118 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazumi Sugihara: "Ah-receptor-mediated Induction of Drug-metabolizing Enzymes by Indirubin and Indigo"Organohalogen Compounds. 59. 453-456 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shigeyuki Kitamura: "In Vitro Metabolism of Fenthion and Fenthion Sulfoxide by Liver Preparations of Sea Bream. Goldfish and Rats"Drug Metabolism and Disposition. 31(2). 179-186 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takashi Fujimoto: "Estrogenic Activity of an Environmental Pollutant, 2-Nitrofluorene, after Metabolic Activation by Rat Liver Microsomes"Biochemical and Biophysical Research Communications. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Osamu Ueda: "Xanthine Oxidase-Catalyzed Metabolism of 2-Nitrofluorene, a Carcinogenic Air Pollutant, in Rat Skin"Drug Metabolism and Disposition. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shigeyuki Kitamura: "Estrogenic Activity of Styrene Oligomers after Metabolic Activation by Rat Liver Microsomes"Environmental Health Perspectives. 111(3). 329-334 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shigeyuki Kitamura: "Antiandrogenic Activity of the Organophosphorus Pesticide Fenthion and Related Compounds, and the Effect of Metabolism"Environmental Health Perspectives. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 北村繁幸: "新しい臨床検査:内分泌撹乱物質の検査"株式会社 現代医療社. 6 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] O.Ueda, S.Kitamura, Y.Furuse, T.Saito, Y.Kanzaki, Y.Yano, K.Tatsumi and S.Ohta: "Metabolism of 2-Nitrofluorene, an Environmental Pollutant, and 2-Acetylaminofluorene in Fish"Bull.Environ.Contam.Toxicol.. 66(3). 371-378 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] O.Ueda, S.Kitamura, R.Kubo, Y.Yano, Y.Kanzaki, T.Fujimoto, K.Tatsumi and S.Ohta, Osamu Ueda: "Metabolism of 2-Nitrofluorene, 2-Aminofluorene and 2-Acetylaminofluorene in Rat and Dog and the Role of Intestinal Bacteria"Xenobiotica. 31(1). 33-49 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Sugihara, S.Kitamura, T.Yamada, S.Ohta, K.Yamashita, M.Yasuda and Y.Fujii-Kuriyama: "Aryl Hydrocarbon Receptor (AhR)-Mediated Induction of Xanthine Oxidase/Xanthine Dehydrogenase Activity by 2, 3, 7, 8-Tetrachloro-dibenzo-p-dioxin"Biochemical and Biophysical Research Communications. 281(5). 1093-1099 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Takekawa, K.Sugihara, S.Kitamura and S.Ohta: "Enzymatic and Nonenzymatic Reduction of Brucine N-Oxide by Aldehyde Oxidase and Catalase"Xenobiotica. 31(11). 769-782 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, K.Nakatani, K.Ohashi, S.Kanbara, Y.Hirao, K.Sugihara, R.Hosokawa, Y.Akagawa and S.Ohta: "Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver"Biol.Pharm.Bull.. 24(7). 856-859 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Takekawa, S.Kitamura, K.Sugihara and S.Ohta: "Nonenzymatic Reduction of Aliphatic Tertiary Amine N-Oxides Mediated by the Heme Moiety of Cytochrome P450"Xenobiotica. 31(1). 11-23 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] O.Ueda, S.Kitamura, and S.Ohta: "Deacylation of N-Arylformides and N-Aryl- acetamides by Formamidase in Rat Liver"Drug Metabolism and Disposition. 30(12). 1297-1299 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, N.Jinno, S.Ohta, H.Kuroki and N.Fujimoto: "Thyroid Hormonal Activity of the Flame Retardants Tetrabromobisphenol A and Tetrachlorobisphenol A"Biochemical and Biophysical Research Communications. 293(1). 554-559 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] O.Ueda, S.Kitamura, and S.Ohta: "Metabolism of 2-Nitrofluorene, an Environmental Pollutant, by Liver Preparations of Sea Bream, Pagrus major"Xenobiotica. 32(8). 667-682 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, Y.Kohno, Y.Okamoto, M.Takeshita and S.Ohta: "Reductive Metabolism of α,β-Ketoalkyne, 4-Phenyl-3-butyn-2-one, by Rat Liver Preparations"Drug Metabolism and Disposition. 30(4). 414-420 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Sanoh, S.Kitamura, K.Sugihara and S.Ohta: "Clytochrome P450 1Al/2 Mediated Metabolism of trans-Stilbene in Rats and Humans"Biological and Pharmaceutical Bulletin. 25(3). 397-400 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, Y.Shimizu, Y.Shiraga, M.Yoshida, K.Sugihara and S.Ohta: "Reductive Metabolism of p, p'-DDT and o, p'-DDT by Rat Liver Cytochrome P450"Drug Metabolism and Disposition. 30(2). 113-118 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Sugihara, T.Yamada, S.Kitamura, S.Ohta, K.Yamashita, S.Okamura, M.Yasuda, Y.Fujii-Kuriyama, K.Saeki, S.Matsui and T.Matuda: "Ah-receptor-mediated Induction of Drug-metabolizing Enzymes by Indirubin and Indigo"Organohalogen Compounds. 59. 453-456 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, Y.Shiraga, Y.Shimizu, K.Sugihara and S.Ohta: "Reductive Metabolism of p, p'-DDT and o, p'-DDT by Rat Liver Cytochrome P450"Organohalogen Compounds. 56. 37-40 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Fujimoto, S.Kitamura, S.Sanoh, K.Sugihara, S.Yoshihara, N.Fujimoto and S.Ohta: "Estrogenic Activity of an Environmental Pollutant, 2-Nitrofluorene, after Metabolic Activation by Rat Liver Microsomes"Biochemical and Biophysical Research Communications. 303. 419-426 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] O.Ueda, S.Kitamura, K.Ohashi, K.Sugihara and S.Ohta: "Xanthine Oxidase-Catalyzed Metabolism of 2-Nitrofluorene, a Carcinogenic Air Pollutant, in Rat Skin"Drug Metabolism and Disposition. 31(4). 367-372 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, T.Suzuki, T.Kadota, M.Yoshida, K.Ohashi and S.Ohta: "In Vitro Metabolism of Fenthion and Fenthion Sulfoxide by Liver Preparations of Sea Bream, Goldfish and Rats"Drug Metabolism and Disposition. 31(2). 179-186 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, M.Ohmegi, S.Sanoh, K.Sugihara, S.Yoshihara, N.Fujimoto and S.Ohta: "Estrogenic Activity of Styrene Oligomers after Metabolic Activation-by Rat Liver Microsomes"Environmental Health Perspectives. 111(3). 329-334 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, T.Suzuki, S.Ohta and N.Fujimoto: "Antiandrogenic Activity of and Metabolism of the Organophosphorus Pesticide Fenthion and Related Compounds"Environmental Health Perspectives. 111(4). 503-508 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kitamura, S.Sanoh, R.Kohta, T.Suzuki, K.Sugihara, N.Fujimoto and S.Ohta: "Metabolic activation of proestrogenic diphenyl and related compounds by rat liver microsomes"Journal of Health Science. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koji Takekawa: "Enzymatic and Nonenzymatic Reduction of Brucine N-Oxide by Aldehyde Oxidase and Catalase"Xenobiotica. 31(11). 769-782 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver"Biological and Pharmaceutical Bulletin. 24(7). 856-859 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kazumi Sugihara: "Aryl Hydrocarbon Receptor (AhR)-Mediated Induction of Xanthine Oxidase/Xanthine Dehydrogenase Activity by 2,3,7,8-Tetrachlorodibenzo-p-dioxin"Biochemical and Biophysical Research Communications. 281(5). 1093-1099 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, an Environmental Pollutant, and 2-Acetylaminofluorene in Fish"Bulletin of Environmental Contamination and Toxicology. 31(1). 371-378 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, 2-Aminofluorene and 2-Acetylaminofluor in Rat and Dog and the Role of Intestinal Bacteria"Xenobiotica. 31(1). 33-49 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Koji Takekawa: "Nonenzymatic Reduction of Aliphatic Tertiary Amine N-Oxides Mediated by the Hame Moiety of Cytochrome P450"Xenobiotica. 31(1). 11-23 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Osamu Ueda: "Deacylation of N-Arylformides and N-Arylacetamides by Formamidase in Rat Liver"Drug Metabolism and Disposition. 31(12). 1297-1299 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Thyroid Hormonal Activity of the Flame Retardants Tetrabromobisphenol A and Tetrachlorobisphenol A"Biochemical and Biophysical Research Communications. 293(1). 554-559 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, an Environmental Pollutant, by Liver Preparations of Sea Bream, Pagrus major"Xenobiotica. 32(8). 667-682 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Reductive Metabolism of α,β-Ketoalkyne, 4-Phenyl-3-butyn-2-one, by Rat Liver Preparations"Drug Metabolism and Disposition. 30(4). 414-420 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Seigo Sanoh: "Cytochrome P450 1A1/2 Mediated Metabolism of frans-Stilbene in Rats and Humans"Biological and Pharmaceutical Bulletin. 25(3). 397-400 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Reductive Metabolism of p, p'-DDT and o, p'-DDT by Rat Liver Cytochrome P450"Drug Metabolism and Disposition. 30(2). 113-118 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kazumi Sugihara: "Ah-receptor-mediated Induction of Drug-metabolizing Enzymes by Indirubin and Indigo"Organohalogen Compounds. 59. 453-456 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "In Vitro Metabolism of Fenthion and Fenthion Sulfoxide by Liver Preparations of Sea Bream. Goldfish and Rats"Drug Metabolism and Disposition. 31(2). 179-186 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takashi Fujimoto: "Estrogenic Activity of an Environmental Pollutant, 2-Nitrofluorene, after Metabolic Activation by Rat Liver Microsomes"Biochemical and Biophysical Research Communications. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Osamu Ueda: "Xanthine Oxidase-Catalyzed Metabolism of 2-Nitrofluorene, a Carcinogenic Air Pollutant, in Rat Skin"Drug Metabolism and Disposition. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Estrogenic Activity of Styrene Oligomers after Metabolic Activation by Rat Liver Microsomes"Environmental Health Perspectives. 111(3). 329-334 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Antiandrogenic Activity of the Organophosphorus Pesticide Fenthion and Related Compounds, and the Effect of Metabolism"Environmental Health Perspectives. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] 北村繁幸: "新しい臨床検査:内分泌撹乱物質の検査"株式会社 現代医療社. 6 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, an Environmental Pollutant, and 2-Acetylaminofluorene in Fish"Bull. Environ. Contam. Toxicol. 66(3). 371-378 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, 2-Aminofluorene and 2-Acetylaminofluorene in Rat and Dog and the Role of Intestinal Bacteria"Xenobiotica. 31(1). 33-49 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kazumi sugihara: "Aryl Hydrocarbon Receptor-Mediated Induction of Xanthine Oxidase/Xanthine Dehydrogenase Activity by TCDD."Biochemical and Biophysical Research Communications. 281(5). 1093-1099 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koji Takekawa: "Nonenzymatic Reduction of Aliphatic Tertiary Amine N-Oxides Mediated by the Heme Moiety of Cytochrome P450"Xenobiotica. 31(1). 11-23 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver"Biological and Pharmaceutical Bulletin. 24(7). 856-859 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koji Takekawa: "Enzymatic and Nonenzymatic Reduction of Brucine N-Oxide by Aldehyde Oxidase and Catalase"Xenobiotica. 31(11). 769-782 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Reductive Metabolism of p, p'-DDT and o, p'-DDT by Rat Liver Cytochrome P450"Drug Metabolism and Disposition. 30(2). 113-118 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Seigo Sanoh: "Cytochrome P450 1A1/2 Mediated Metabolism of trans-Stilbene in Rats and Humans"Biological and Pharmaceutical Bulletin. 25(3). 397-400 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shigeyuki Kitamura: "Reductive Metabolism of α,β-Ketoalkyne, 4-Phenyl-3-butyn-2-one, by Rat Liver Preparations"Drug Metabolism and Disposition. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Osamu Ueda: "Metabolism of 2-Nitrofluorene, an Environmental Pollutant, by Liver Preparations of Sea Bream, Pagrus"Xenobiotica. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 北村繁幸: "新しい臨床検査:内分泌撹乱物質の検査"株式会社 現代医療社. 309-314 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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