• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on factors contributing adverse drug reactions: establishment of a rational drug dosage system

Research Project

Project/Area Number 13672393
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 応用薬理学・医療系薬学
Research InstitutionOITA MEDICAL UNIVERSITY

Principal Investigator

NAKANO Shigeyuki  Oita Medical University, School of Medicine, Professor, 医学部, 教授 (10033341)

Co-Investigator(Kenkyū-buntansha) 小手川 喜美子  大分医科大学, 医学部, 助手 (20244171)
小手川 勤  大分医科大学, 医学部, 助教授 (20264343)
NAKAMURA Koichi  Oita Medical University, School of Medicine, Assoiciate Professor, 医学部, 助教授 (30045520)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsimpaired performance / bromazepam / digoxin / theophylline / quazepam / itraconazole / fluconazole / St John's wort / bromzepam / theophylline / St John's wort / CYP2C9 / CYP3A4 / マクロライド系抗菌薬 / P糖蛋白質 / 薬物相互作用 / ワープロ法 / 日常作業効率 / lorazepam
Research Abstract

For the purpose of this research, we carried out five clinical studies.
(1) A new computerized test battery to evaluate drug effects on psychomotor performance: Lorazepam-induced performance in healthy volunteers
Lorazepam-induced impaired psychomotor performance was objectively and sensitively detected in healthy subjects with no sujective feeling change using our newly developed computerized test battery. This objective method can be applied to more precisely evaluate the drug induced impaired psychomotor performance.
(2) The effect of erythromycin and clarithromycin on the phamacokinetics of intravenous digoxin in healthy volunteers
We observed a significant increase in digoxin renal clearance after coadministration of erythromycin and clarithromycin. However, serum digoxin disposition is not affected by either marcrolide when digoxin is administered intravenouly. These findings do not support the hypothesis that the increase in digoxin concentrations by macrolides is due to reduced ren … More al excretion of digoxin.
(3) The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healty volunteers
The inhibition of cytochrome P450(CYP) 3A4 produced by itraconazole did not alter the pharmacokinetics and pharmacodynamics of bromazepam. It is likely that CYP3A4 plays a minor role, if any, in the metabolism of bromazepam. When using benzodiazepiners in patients with altered CYP3A4 activity, bromazepam can be one of the alternatives as well as lorazepam that are metabolized by glucuronidation.
(4) Effect of St John's wort (SJW) on the pharmacokinetics of theophylline in health volunteers
The 15-day treatment with SJW produced no significant changes in the pharmcokinetics of theophylline in plasma. However, it is likely that the metabolism of theophylline is affected by SJW as indicated by the change in the urinary metabolite ration of 1-methyluric acid.
(5) The effect of itraconazole and fluconazole on the pharmacodynamics of quazepam in healthy volunteers
Compared with placebo, impairment of psychomotor performance with quazepam was significantly diminished after coadministration of fluconazole. This is probably due to the inhibition of CYP2C9 and CYP3A4 by fluconazole, which reduces productions of active metabolites of quazepam. Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Sunami Y, Tsutsumi K, Kotegawa T, Nakamura K, Nakano S: "A new computerized test battery to evaluate drug effects on psychomotor performance : Lorazepam-induced impaired perfoemance in healthy volunteers"Jpn J Clin Pharmancel Ther. 33. 73-79 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsutsumi K, Kotegawa T, Kuranari M, Ohtani Y, Moerimoto T, Matsuki S, Nakano S: "The effect of erythromycin and clarithromycin on the pharmacokinetics of intravenous digoxin in healthy volunteers"J Clin Pharmacol. 42. 1159-1164 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sunami Y, Tsutsumi K, Kotegawa T, Nakamura K, Nakano S: "A new computerized test battery to evaluate drug effects on psychomotor performance: Lorazepam-induced impaired performance in healthy volunteers"Jpn Clin Pharmacol Ther. 33(3). 73-79 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsutsumi K, Kotegawa T, Kuranari M, Ohtani Y, Morimoto T, Matsuki S, Nakano S: "The effect of erythromycin and clarithromycin on the pharmacokinetics if intravenous digoxin in healthy volunteers"J Clin Pharmacol. 42(10). 1159-1164 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sunami Y: "A new computerized test battery to evaluate drug effects on psychomotor performance : Lorazepam-induced impaired performance in healthy volunteers"Jpn J Clin Pharmacol Ther. (In Press).

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi