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Analysis of SNPs and pathogenesis of human Protein 1 gene

Research Project

Project/Area Number 13672411
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

KAWABATA Isao  Asahikawa Medical College, Dep.of Medical Laboratory, Zyosyu, 医学部, 助手 (50195129)

Co-Investigator(Kenkyū-buntansha) ITO Yosihisa  Asahikawa Medical College, Dep.of Medical Laboratory, professor, 医学部, 教授 (20129026)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsCC10 / uteroglobin / IgA nephropathy / SNPs / interferon-gamma / sarcoidosis / サルコイドーシス / IgA腎症 / SNP / Single Nucleotide Polymorphisms / IgA Nephropathy
Research Abstract

Clara cell 10-kDa protein (CC10)/uteroglobin (UG) is a nonglycoprotein with a molecular mass of 16 kilodaltons, which is produced by mucosal epithelial cells in the lung (Clara cells), uterus and prostate.
We analyzed the UG gene as a candidate for a predisposing factor in 61 Japanese patients with IgA nephropathy (23 children, 38 adults) and detected only the G38A mutation. The gene frequency of the G38A mutation in patients was 0.43, not significantly different from the frequency of 0.36 in healthy controls. However, the frequency of patients homozygous for G38A was twice that of controls, and a significant increase was seen in child patients. We measured serum UG levels in patients and healthy adults. A significant decrease in serum UG levels in homozygotes of G38A compared with homozygotes of G38 was detected only in adult women patients and controls.
The value is changed in the lung fluid and serum of various inflammatory and allergic lung diseases. Several kinds of single nucleotide polymorphisms (SNPs) in human CC10/UG gene were recently discovered ; Adenine allele accumulation in G38A SNP has possible association with asthma and IgA nephropathy, being paralleled with disease severity of IgA nephropathy. Its expression is enhanced by some transcriptional factors induced by cytokines such as interferon-gamma. For cancer cells, the protein functions as an antagonist of neoplastic phenotype.
We also analyzed the expression of uteroglobin in 15 menopausal women who received hormone replacement therapy (HRT). The expression of uteroglobin was higher during the secretory phase than in the proliferative phase, however, it was detected in endometrial hyperplasia as weakly as in the proliferative phase and decreased according to the loss of differentiation in endometrial carcinoma.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Akira Matsunaga: "Association of the Uteroglobin Gene Polymorphism with IgA Nephropathy"American Journal of Kidney Diseases. 39. 36-41 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 河端 薫雄: "遺伝子検査によるオーダーメイド医療"臨床病理. Vol.50. 1124-1129 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shijubo N.: "Clinical aspects of Clara cell 10-kDa protein/uteroglobin(secretoglobin 1A1)."Curr Pharm Des.. Vol.9. (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohchi T.: "Polymorphism of Clara cell 10-kD protein gene of sarcoidosis."Am J Respir Crit Care Med.. 162. 180-186 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 四十坊典晴: "クララ10kDa蛋白質"臨床化学. 32. 227-233 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ryoichi Tanaka: "Expression of uteroglobin in normal and carcinogenic endometrium and influence of hormone replacement therapy"Int.J.Cancer. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawabata I. Itoh Y.: "Present and future prospects of individualized medical services by genetic tests"Rinsho Byori.. 50(12). 1124-1129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsunaga A, Numakura C, Kawakami T, Itoh Y, Kawabata I, Masakane I, Suzuki T, Suzuki M, Goto T, Itoh K, Hayasaka K.: "Association of the uteroglobin gene polymorphism with IgA nephropathy."Am J Kidney Dis.. 39(1). 36-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohchi T, Shijubo N, Kawabata I, Ichimiya S, Inomata S, Yamaguchi A, Umemori Y. Itoh Y, Abe S. Hiraga Y. Sato N.: "Polymorphism of Clara cell 10-kD protein gene of sarcoidosis"Am J Rcspir Cnt Care Med.(Jan 15 Epub 2003 Oct 09). 169(2). 180-186 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shijubo N, Kawabata I, Sato N, Itoh Y.: "Clinical aspects of Clara cell 10-kDa protein/uteroglobin (secretoglobin 1A1)."Curr Pharm Des.. 9(14). 227-233 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shijubo N, Kawabata I, Itoh Y.: "Clara cell 10-LD protein"Rinnsyokagaku. 32. 227-233 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka R, Saito T, Shijubo N, Takehara M, Yamada G, Kawabata I, Itoh Y, Kudo R.: "Expression of uteroglobin in normal and carcinogenic endometrium and influence of hormone replacement therapy."Int J Cancer. 109(1). 43-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shijubo N.: "Clinical aspects of Clara cell 10-kDa protein/uteroglobin (secretoglobin 1A1)"Curr Pharm Des.. 9・(14). 1139-1149 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohchi T.: "Polymorphism of Clara cell 10-kD protein gene of sarcoidosis"Am J Respir Crit Care Med.. 169(2). 180-186 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 四十坊典晴: "クララ10kDa蛋白質"臨床化学. 32巻. 227-233 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 河端 薫雄: "遺伝子検査によるオーダーメイド医療"臨床病理. Vol.50 No.12. 1124-1129 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noriharu Shijobo: "Clinical aspects of Clara cell 10-kDa protein/uteroglobin (secretoglobin 1A1)"Current Pharmaceutical Design. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akira Matsunaga: "Association of the Uteroglobin Gene Polymorphism with IgA Nephropathy"American Journal of Kidney Diseases. Vol 39, No 1. 36-41 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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