| Project/Area Number |
13680778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
IWASAKI Hideo Nagoya Univ.Graduate School of Science Research Associate, 大学院・理学研究科, 助手 (00324393)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Takao Nagoya Univ.Graduate School of Science Professor, 大学院・理学研究科, 教授 (10124223)
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| Project Period (FY) |
2002 – 2003
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | circadian / biological clock / phosphorylation / Kai / Sas A / kai / 概日リズム / シアノバクテリア |
|---|
| Research Abstract |
Circadian rhythms have been observed in many organisms at a variety of physiological processes. Cyanobacteria are the simplest organisms to exhibit circadian rhythms, and provide a well-established molecular genetic and physiological model system. In the current study, we revealed that a master clock element protein, KaiC, exhibits autokinase/autophosphatase activities, which are dramatically modified by associating clock proteins, KaiA and KaiB. Relationship among circadian dynamics of protein-protein interactions among clock proteins, phosphorylation of KaiC and their cellular localization will be a basis for further functional analyses on the mechanism to generate circadian rhythms in the prokaryote.
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