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Analysis of the mechanism underlying the pathway formation using mutant animals.

Research Project

Project/Area Number 13680832
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

KAWANO Hitoshi  Tokyo Metropolitan Institute for Neuroscience Staff Scientist, 東京都神経科学総合研究所, 副参事研究員 (20161341)

Co-Investigator(Kenkyū-buntansha) HORIE Masao  Tokyo Metropolitan Institute for Neuroscience Technician, 東京都神経科学総合研究所, 研究員 (70322716)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsmutant / Calbindin / N-syndecan / Brn-2 / Nkx2.1 / Pax-6 / NB3 / Pathway formation / 突然変異 / ノックアウトマウス / 脳 / 形態形成 / Nxk2.1 / TAG-1
Research Abstract

We have examined the brain development in both normal and mutant animals by chiefly using the morphological technique. Recent findings obtained are as follows.
1) Calbindin D-28k, a calsium-binding protein, is localized in neurons migrating from the nascent vomeronasal organ to the brain in rats (Toba et al., 2001). N-syndecan, a heparansulfate proteoglycan, is expressed in the migratory route from the rat olfactory placode (Toba et al., 2002).
2) Defects of the development and pathway formation of hypothalamic neurosecretory neurons were found in animals lacking transcription factors Brn-2, Nkx2.1 and Pax-6 (Kawano et al., 2002).
3) The abnormal development of cerebral neocortex is observed in double-knockout mice lacking both Brn-1 and Brn-2 (Sugitani et al., 2002).
4) InPax-6 mutant rats, precerebellar neurons of the medulla oblongata exhibit a delayed migration and aberrant migratory route (Horie et al., 2003).
5) Ascending dopaminergic axons of the mesencephalon abnormally cross the midline in knochout mice lacking Nkx2.1 (Kawano et al., 2003).
6) The motor function of mice lackingNB3, a cell recognition molecule, is abnormal (Takeda et al., 2003).

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Takeda, Y.: "Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subfamily"J.Neurobiol.. (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawano, H.: "Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1"Exp.Neurol.. (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Horie, M.: "Subpial neuronal migration in the fetal rat medulla oblongata with Pax-6 deficiency"Eur.J.neurosci.. 17(1). 49-57 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugitani, Y.: "Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons"Genes & Dev. 16(14). 1760-1765 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toba, Y.: "Expression and immunohistochemical localization of heparan sulfate proteoglycan N-syndecan in the migratory pathway from the rat olfactory placode"Eur.J.Neurosci.. 15. 1461-1473 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toba, Y.: "Immunohistochemical localizaion of calbindin D-28k in the migratory pathway from the rat olfactory placode"J.Neuroendocrinol.. 13(8). 683-694 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawano, H: "Neuroplasticity Development & Hormone Action"CRC Press LLC. (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeda Y: "Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subfamily"Exp. Neurol.. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sango K: "Phosphacan and neurocan are repulsive substrates for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro"J. Neurobiol.. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawano H: "Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1"Exp. Neurol.. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Horie M: "Subpial neuronal migration in the fetal rat medulla oblongata with Pax-6 deficiency"Eur. J. Neurosci.. 17(1). 49-57 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugitani, Y: "Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons"Genes & Dev.. 16(14). 1760-1765 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ueda, H: "Enhanced SUMOylation in polyglutamine disease"Biochem. Biophys. Res. Comm.. 293. 307-313 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sango, K: "Diabetes is not a potent inducer of neuronal cell death in mouse sensory ganglia, but it enhances neurite regeneration in vitro"Life Sci.. 71(20). 2351-2368 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toba, Y: "Expression and immunohistochemical localization of heparan sulfate proteoglycan N-syndecan in the migratory pathway from the rat olfactory placode"Eur. J. Neurosci.. 15. 1461-1473 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawano, H: "Melanin-concentrating hormone: the wide web that controls feeding"Anat. Sci. Int.. 77. 149-160 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toba, Y: "Immunohistochemical localization of calbindin D-28k in the migratory pathway from the rat olfactory placode"J. Neuroendocrinol.. 13(8). 683-694 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawano, H: "Roles of transcription factors in the development of the hypothalamic neuroendocrine system, Neuroplasticity, Development & Hormone Action"CRC Press. 21-29 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeda, Y.: "Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subfamily"J. Neurobiol.. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawano, H.: "Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1."Exp. Neurol.. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Horie, M: "Subpial neuronal migration in the fetal rat medulla oblongata with Pax-6 deficiency"Eur. J. neurosci.. 17(1). 49-57 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sugitani, Y.: "Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons"Genes & Dev. 16(14). 1760-1765 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toba, Y.: "Expression and immunohistochemical localization of heparan sulfate proteoglycan N-syndecan in the migratory pathway from the rat olfactory placode"Eur. J. Neurosci.. 15. 1461-1473 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toba, Y.: "Immunohistochemical localization of calbindin D-28k in the migratory pathway from the rat olfactory placode"J. Neuroendocrinol.. 13(8). 683-694 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawano, H: "Neuroplasticity Development & Hormone Action"CRC Press LLC. 9 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fukamauchi F.: "TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus"Biochem. Biophys. Res. Commun.. 281 1. 220-226 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toba Y.: "Immunohistochemical localization of calbindin D-28k in the migratory pathway from the rat olfactory placode"J. Neuroendocrinol.. 13 8. 683-694 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawano H.: "Neuroplasticity Development & Hormone Action"CRC Press. 9 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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