| Co-Investigator(Kenkyū-buntansha) |
HORI Etsuro Toyama Medical and Pharmaceutical University, Faculty of Medicine, Instructor, 医学部, 助手 (90313600)
UMENO Katsumi Toyama Medical and Pharmaceutical University, Faculty of Medicine, Instructor, 医学部, 助手 (90086596)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Research Abstract |
The limbic system which includes the hippocampus, the amygdala, the cingulate cortex, plays important role on emotion, spatial recognition, episodic memory, and their ongoing behavior. To elucidate the integrated function of information processing in the limbic system, we recorded multiple single neuronal activities simultaneously from the posterior cingulate cortex, and analyzed the neuronal responses in spatial sensory-reward association task. In this task, the rats received intracranial self-stimulation (ICSS) or sucrose solution (both reward), following 2 s sensory stimulus (light or sound) plus 1 s delay. Then, we compared the neuronal functions among the hippocampus, amygdala, and posterior cingulate cortex.
Behavioral correlates of the posterior cingulate cortex neurons showed that 1) more than half responded to ICSS and sucrose solution, 2) most did not respond to sensory stimuli, 3) some correlated highly with drinking (licks), which were activated a few 10 ms after respective licks. These findings support an idea that the posterior cingulate cortex functions as motor evaluation by analyzing information from the hippocampal, amygdalar, and motor inputs.
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