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Mechanism of motor output system in the posterior cingulate cortex due to integration of hippocampal and amygdalar functions

Research Project

Project/Area Number 13680865
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

TABUCHI Eiichi  Toyama Medical and Pharmaceutical University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (70272911)

Co-Investigator(Kenkyū-buntansha) HORI Etsuro  Toyama Medical and Pharmaceutical University, Faculty of Medicine, Instructor, 医学部, 助手 (90313600)
UMENO Katsumi  Toyama Medical and Pharmaceutical University, Faculty of Medicine, Instructor, 医学部, 助手 (90086596)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsLimbic System / Cingulate Cortex / Posterior Cingulate Cortex / Amygdala / Hippocampus / Neuron / Cross-correlation / Motor Output / 相互関係解析 / 相互相関法
Research Abstract

The limbic system which includes the hippocampus, the amygdala, the cingulate cortex, plays important role on emotion, spatial recognition, episodic memory, and their ongoing behavior. To elucidate the integrated function of information processing in the limbic system, we recorded multiple single neuronal activities simultaneously from the posterior cingulate cortex, and analyzed the neuronal responses in spatial sensory-reward association task. In this task, the rats received intracranial self-stimulation (ICSS) or sucrose solution (both reward), following 2 s sensory stimulus (light or sound) plus 1 s delay. Then, we compared the neuronal functions among the hippocampus, amygdala, and posterior cingulate cortex.
Behavioral correlates of the posterior cingulate cortex neurons showed that 1) more than half responded to ICSS and sucrose solution, 2) most did not respond to sensory stimuli, 3) some correlated highly with drinking (licks), which were activated a few 10 ms after respective licks. These findings support an idea that the posterior cingulate cortex functions as motor evaluation by analyzing information from the hippocampal, amygdalar, and motor inputs.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Zugaro M.B., et al.: "Active locomotion increases peak firing rates of anterior dorsal thalamic head direction cells"Journal of Neurophysiology. 86. 692-702 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Goso Y., et al.: "Respiratory modulation of muscle sympathetic nerve activity in patients with chronic heart failure"Circulation. 104. 418-423 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hori, E., et al.: "Effects of a novel arginine-vasopressin derivative, NC-1900, on the spatial memory impairment of rats with transient forebrain ischemia"Cognitive Brain Research. 13. 1-15 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Joho S., et al.: "Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia"Journal of American Collage of Cardiology. 39. 436-442 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tabuchi E., et al.: "Spatio-temporal dynamics of brain activated regions during drinking behavior in rats"Brain Research. 951. 270-279 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tabuchi E., et al.: "Reward value invariant place responses and reward site associated activity in hippocampal neurons of behaving rats"Hippocampus. 13. 117-132 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hori E., et al.: "Representation of place by monkey hippocampal neurons in real and virtual translocation"Hippocampus. 13. 148-154 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishimura F.T., et al.: "Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects"Autonomic Neuroscience-Basic & Clinical. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Umeno K., et al.: "Gamma-band EEGs predict autonomic responses during mental arithmetic"Neuroreport. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takakura M., et al.: "Differential activation in the medial temporal lobe during a sound-sequence discrimination task across age in human subjects"Neuroscience. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 数井健一: "仮想現実空間探索課題におけるサル海馬体ニューロンの応答性"信学技報. MBE. 3-5 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 西条寿夫: "食物のおいしさと食欲の調節機構「フードデザイン21」"サイエンスフォーラム. 124-137 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto G., et al.: "Role of the monkey amygdala in social cognition. In : Cognition and Emotion in the Brain"Elsevier(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 西条寿夫: "表情認知の神経機構-他者の意図推定における扁桃体の役割-"脳と精神の医学(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Zugaro M.B., et al.: "Active locomotion increases peak firing rates of anterior dorsal thalamic head direction cells."Journal of Neurophysiology. 86. 692-702 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Goso Y., et al: "Respiratory modulation of muscle sympathetic nerve activity in patients with chronic heart failure."Circulation. 104. 418-423 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hori E., et al.: "Effects of a novel arginine-vasopressin derivative, NC-1900, on the spatial memory impairment of rats with transient forebrain ischemia."Cognitive Brain Research. 13. 1-15 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Joho S., et al.: "Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia."Journal of American Collage of Cardiology. 39. 436-442 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tabuchi E., et al.: "Spatio-temporal dynamics of brain activated regions during drinking behavior in rats."Brain Research. 951. 270-279 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tabuchi E., et al.: "Reward value invariant place responses and reward site associated activity in hippocampal neurons of behaving rats."Hippocampus. 13. 117-132 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hori E., et al.: "Representation of place by monkey hippocampal neurons in real and virtual translocation."Hippocampus. 13. 148-154 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishimura F.T., et al.: "Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects."Autonomic Neuroscience-Basic & Clinical. in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Umeno K., et al.: "Gamma-band EEGs predict autonomic responses during mental arithmetic."Neuroreport. in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takakura M., et al.: "Differential activation in the medial temporal lobe during a sound-sequence discrimination task across age in human subjects."Neuroscience. in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto G., et al.: "Role of the monkey amygdala in social cognition. In: Cognition and Emotion in the Brain."Elsevier. in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Zugaro M.B., et al.: "Active locomotion increases peak firing rates of anterior dorsal thalamic head direction cells"Journal of Neurophysiology. 86. 692-702 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Goso Y., et al.: "Respiratory modulation of muscle sympathetic nerve activity in patients with chronic heart failure"Circulation. 104. 418-423 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hori E., et al.: "Effects of a novel arginine-vasopressin derivative, NC-1900, on the spatial memory impairment of rats with transient forebrain ischemia"Congnitive Brain Research. 13. 1-15 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Joho S., et al.: "Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia"Journal of American Collage of Cardiology. 39. 436-442 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tabuchi E., et al.: "Spatio-temporal dynamics of brain activated regions during drinking behavior in rats"Brain Research. 951. 270-279 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tabuchi E., et al.: "Reward value invariant place responses and reward site associated activity in hippocampal neurons of behaving rats"Hippocampus. 13. 117-132 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hori E., et al.: "Representation of place by monkey hippocampal neurons in real and virtual translocation"Hippocamus. 13. 148-154 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishimura F.T., et al.: "Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects"Autonomic Neuroscience-Basic & Clinical. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Umeno K., et al.: "Gamma-band EEGs predict autonomic responses during mental arithmetic"Neuroreport. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Takakura M., et al.: "Differential activation in the medial temporal lobe during a sound-sequence discrimination task across age in human subjects"Neuroscience. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] 数井 健一: "仮想現実空間探索課題におけるサル海馬体ニューロンの応答性"信学技報. MBE. 3-5 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 西条寿夫: "食物のおいしさと食欲の調節機構.「フードデザイン21」"サイエンスフォーラム. 124-137 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsumoto G., et al.: "Role of the monkey amygdala in social cognition. In : Congnition and Emotion in the Brain"Elsevier(in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] 西条寿夫: "表情認知の神経機構 -他者の意図推定における扁桃体の役割-"脳と精神の医学(in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Tabuchi, E., Mulder, A. B., Wiener, S. I.: "Reward value invariant place responses and reward site associated activity in hippocampal neurons of behaving rats. Hippocampus, in press"Hippocampus. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hori, E., Tabuchi E., Matsumura, N., Tamura, R., Eifuku, S., et al.: "Representation of place by monkey hippocampal neurons in real and virtual translocation"Hippocampus. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Zugaro, M. B., Tabuchi, E., Fouquier, C., Berthoz, A., Wiener, S. I.: "Active locomotion increases peak firing rates of anterior dorsal thalamic head direction cells"Journal of Neurophysiology. 86. 692-702 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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