| Project/Area Number |
13680867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Shinshu University |
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Principal Investigator |
NAKAYAMA Kohzo Shinshu University, School of Medicine, lecturer, 医学部, 講師 (70192680)
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| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Delta / Notch / Preplate / sub plate / Cajal-Retzins / Cortical Plate / 大脳皮質 |
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| Research Abstract |
The preplate is composed by earliest generated neuron, including Cajal-Retzius cells and prospected subplate neuron which together play a critical role in the formation of cortical layers. Additionally, Notch and Delta have been identified as key components that mediate the lateral specification and fate of numerous cells during development. Here, we demonstrate that divergent type of Delta (D113) is expressed transiently and specifically in a set of earliest generated neuron in neural tube. Moreover, in developing cerebrum, D113 is specifically and transiently expressed in prospected subplate neurons. Thus, our results suggest that D113 mediates the specification of cell fate in the earliest stage of neurogenesis including neurons compose preplate, leading to the mechanism of genesis of cortical layers.
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