| Project/Area Number |
13680934
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
KOKUBO Tadashi GRADUATE SCHOOL OF ENGINEERING, PROFESSOR, 工学研究科, 教授 (30027049)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASHITA Masakazu GRADUATE SCHOOL OF ENGINEERING, ASSOCIATE RESEARCHER, 工学研究科, 助手 (70314234)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | CARBOXY GROUP / APATITE / SIMULATED BODY FLUID / CHITIN / ALGINATE / GELLAN GUM / FIBERS / 3D-COMPOSITE / 三次元構造 / 複合体 / カードラン |
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| Research Abstract |
Carboxymethylated chitin and gellan gum, both of which contain carboxy groups, formed an apatite on their surfaces in SBF, only after Ca(OH)_2 solution treatment. Cardlan gels containing no carboxy group did not form the apatite even after the Ca(OH)_2 treatment. Calcium alginate fibers were prepared by extruding sodium alginate solution into calcium chloride solution through a nozzle. Chitin fibers constituting a nonwoven fabric were carboxymethylated. Both of the fibers formed the apatite on their surfaces in SBF, after the Ca(OH)_2 treatment. The calcium ion released from the fibers treated with Ca(OH)_2 solution might form carboxy groups effective for the apatite nucleation on the surface of the fibers and accelerate the apatite nucleation by increasing ionic activity product of the apatite in SBF. The apatiteorganic fiber composite prepared by the present method is expected to be useful as a flexible bioactive b-one repairing material
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