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Effect of Electrical Stimulation to Motor Disturbance in Central Nerves System.

Research Project

Project/Area Number 13680946
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionSapporo Medical University

Principal Investigator

MURAKAMI Shinji  Sapporo Medical University, School of Healthscience, Dep.Of Occupational Therapy, Professor (30142756)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Mariko  Sapporo Medical University, School of Health science, Dep.Of Occupational Therapy, 准教授 (70227940)
GOTO Minako  Sapporo Medical University, School of Health science, Dep.Of Occupational Therapy, 助教 (00295370)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsElectrical Stimulation / More Effective Condition / Histological / Type of Muscle Contraction / Type I Muscle fiber / Type II Muscle fiber / 中枢性運動障害 / 経皮的電気刺激 / 刺激パラメーター / 随意的連続運動 / 中枢神経 / 痙性障害 / 動作解析 / 表面筋電図
Research Abstract

To investigate theraptic electrical stimulation to motor disturbance in central nervous system, we planed to entry the patients with central nervous system disease, however we found few report to research the effective condition of electrical stimulation to muscle contraction. So, we decided to research the more effective electrical stimulation condition for muscle contraction. If we did not get the more effective condition for electrical stimulation to make muscle contraction, the patients would accept less effective therapy. We started to investigate the more effective condition for electrical stimulation using rat preparation.
This research was to determine the morphologic and histologic effects of electrical stimulation(ES) used to prevent muscle atrophy, and to investigate the effects of ES at different stimulation frequencies in preventing atrophy in different muscle fiber types.
Research design was that rats in the hindlimb suspended (HS) plus ES group were subjected to 20-and 30-Hz stimulation (ES1, ES2) Every other day for 2wks.
In our rerearch, short periods of low-intensity, low-stimulation frequency(20Hz) ES of musele during periods of inactivity could maintain changes in both morphologic and histologic properties of the slow-twitch muscle fibers(soleus). Short periods of low-intensity, high-frequency(30Hz) ES of muscle during periods of inactivity could maintain changes in both morphologic and histologic properties of the fast-twitch muscle fibers (extensor digitorum longus).
So, we get the more effective condition for electrical stimulation for muscle contraction and are to prepare clinical research for electrical stimulation to motor disturbance in central nervous system. This research was very important for those electrical stimulation therapy effectively.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (2 results)

All 2009

All Journal Article (2 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Effect of Electrical Stimulation to Prevent Muscle Atrophy on Morphologic and Histologic Properties of Hindlimb Suspended Rat Hindlimb Muscles.2009

    • Author(s)
      Boonyarom, Kozuka, Matsuyama, Murakami
    • Journal Title

      American Journal of Physical Medicine and Rehabilitation. 88

      Pages: 719-726

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of Electrical Stimulation to Prevent Muscle Atrophy on Morphological and Histologic Properties of Hindlimb Suspended Rat Hindlimb Muscles2009

    • Author(s)
      Boonyarom Onuma, Kozuka Naoki, Matsuyama Seiichi, Murakami Shinji
    • Journal Title

      American Journal of Physical Medicine and Rehabilitation Vol.88

      Pages: 719-726

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary

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Published: 2001-04-01   Modified: 2016-04-21  

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