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Definitive Diagnosis And Intensive Monitor Of Prostate Diseases Based On Magnetic Resonance Spectroscopic Imaging

Research Project

Project/Area Number 13680953
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTOKAI UNIVERSITY

Principal Investigator

KURODA Kagayaki  Department of Human and Information Sciences The Faculty of Electronic Information, Tokai University, 電子情報学部, 助教授 (70205243)

Co-Investigator(Kenkyū-buntansha) JINZAKI Masahiro  Department of Radiology, School of Medicine, Keio University, 医学部, 講師 (80216259)
SUGIMURA Kazuro  Department of Radiology, School of Medicine, Kobe University, 医学部, 教授 (00136384)
KAJI Yasushi  Department of Radiology, School of Medicine, Kobe University, 医学部, 講師 (10273947)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsMRI / MRS / Proton / Prostate / Metabolite / Citrate / pH / Temperature / プロトン / MRSI / コリン / スペクトル
Research Abstract

It was found that the proton chemical shift of citrate has pH dependency of -0.09 ppm/pH, while that of choline or creatine has no pH dependency. The prostate metabolite measurement system based upon magnetic resonance spectroscopic imaging (MRSI) with the very high tesla (3T) magnet has been constructed. It was also found based on the phantom experiments that the intensity of the citrate signal is modulated by J-coupling and the chemical shift, and that the highest echo signal appears at the echo time of 290 ms. Density matrix simulation adopting J-modulation factor, chemical shift, pulse timing and T2 showed that the highest echo signal of citrate proton appears around 290 ms when the citrate T2 is longer than 133 ms while it is around 145 ms when the T2 is shorter than 133 ms. By fitting the volunteer data on the simulation model curve derived from the density matrix calculation, the citrate T2 value, which has not been reported so far, was estimated as approximately 80 ms.
As for th … More e MR probe development; a new coil element configuration with two pairs of loop coils was developed. Although we first examined suppression of thermal noise by cooling the coil to improve signal to noise, it turned out that increasing signal intensity by minimizing the distance between prostate and the coil elements, and by finely adjusting the shapes of the elements are more significant. The new coil design improved the signal to noise 2.1 times at the peripheral zone and 1.3 times at the central zone of prostate compared with the phased array coil used with a 1.5 T scanner.
Imaging sequence was optimized based on the prostate coil by adjusting the outer volume suppression pulses, water suppression pulses as well as spatial-frequency excitation pulses. High-resolution diagnostic anatomical images as well as high quality metabolite spectra were constantly obtained for twenty healthy volunteers. The spectral band width and signal to noise ratio (S/N) were smaller than 0.1 ppm and higher than 10, respectively, for citrate in the healthy prostates. Scans for patient volunteers with prostate cancers were started at the end of this annual year to examine the ability of the metabolite measurement system for the definitive diagnosis of prostate cancer and benign prostatic hyperplasia (BPH). It is our duty to continuously examine the patient volunteers to establish a practical prostate observation system based on the results obtained by this grant-in-aid.
We deeply thank to the Japan Society for the Promotion of Science (JSPS) for supporting our research. Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] K.Kuroda, N.Takei, R.V.Mulkern, K.Oshio, T.Nakai, T.Okada, A.Matsumura, K.Yanaka, K.Hynynen, F.A.Jolesz: "Feasibility of Internally-Referenced Temperature Imaging Using Metabolite Signals"Magn.Reson.Med.Sci.. 2,1. 17-22 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 黒田 輝: "MRIによる物理計測がもたらすもの"映像医療メディカル. 34,5. 476-479 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 楫 靖, 杉村和朗, 北村ゆり, 竹井直行, 黒田 輝, 塚元鉄二: "超高磁場MRIのインパクト-前立腺MRI-Proton MRSへの期待"映像医療メディカル. 34,5. 438-442 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Kuroda, Y.Kaji, RV Mulkern, N.Takei, Y.Kitamura, M.Tamura, K.Sugimura: "MR Observations of Prostate Metabolites at 3 Tesla"Proc.10th Annual Meeting ISMRM. 1921 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yasushi Kaji, Kagayaki Kuroda, Takaki Maeda, Yuri Kitamura, Yuichiro Matsuoka, Tsuyoski Matsuda, Tetsuji Tsukamoto, Kazuro Sugimura: "MR Imaging and MR Spectroscopy of Prostate at 3 Tesla"Proc.11th Annual Meeting ISMRM. 1542 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 楫 靖, 黒田輝, 竹井直行, 塚元鉄二, 杉村和朗: "3テスラMR装置で観察したクエン酸のhomonuclear coupling"日本磁気共鳴医学会雑誌. 21S. (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 前田隆樹, 楫 靖, 北村ゆり, 杉村和朗, 黒田 輝, 藤原俊孝, 松田 豪, 塚元鉄二: "3テスラMR装置による前立腺Proton MRS:健常ボランティアでの検討"日本磁気共鳴医学会雑誌. 22S. (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Kuroda, N. Takei, R. V. Mulkern, K. Oshio, T. Nakai, T. Okada, A. Matsumura, K. Yanaka, K. Hynynen, F. A. Joles: "Feasibility of Internally-Referenced Temperature Imaging Using Metabolite Signals"Magn. Reson. Med. Sci.. 2, 1. 17-22 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Kuroda: "What physical instrumentation by MRI brings"Image Medicine. 34,5. 476-479 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yasushi Kaji, Kazuro Sugimura, Yuri Kitamura, Naoyuki Takei, Kagayaki Kuroda, Tetsuji Tsukamoto: "The Impact of the very high tesla MRI: Expectation for Prostate, MRI and MRS"Image Medicine. 34, 5. 438-442 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Kuroda, Y. Kaji, RV Mulkern, N. Takei, Y. Kitamura, M. Tamura, K. Sugimura: "MR Observations of Prostate Metabolites at 3 Tesla"Proc. 10h Annual Meeting ISMRM. 1921 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yasushi Kaji, Kagayaki Kuroda, Takaki Maeda, Yuri Kitamura, Yuichiro Matsuoka, Tsuyoshi Matsuda, Tetsuji Tsukamoto, Kazuro Sugimura: "MR Imaging and Spectroscopy of Prostate at 3 Tesla"Proc. 11th Annual Meeting ISMRM. 1542 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yasushi Kaji, Kagayaki Kuroda, Naoyuki Takei, Tetsuji Tsukamoto, Kazuro Sugimura: "Homo-nuclear coupling of citrate observed by a 3 tesla"MRI, JJMR. 21S. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takaki Maeda, Yasushi Kaji, Yuri Kitamura, Kazuro, Sugimura, Kagayaki Kuroda, Toshitaka Fujiwara, Tsuyoshi Matsuda, Tetsuji Tsukamoto: "Proton MRS of Normal Prostates examined by a 3 tesla"MRI, JJMR. 22S. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.Kaji, K.Kuroda, T.Maeda, Y.Kitamura, Y.Matsuoka, Y.Matsuda, Y.Tsukamoto, K.Sugimura: "MR Imaging and MR Spectroscopy of Prostate at 3 Tesla"Proc. 11th Annual Meeting ISMRM, Toronto. 2. 1542 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Kaji, K.Kuroda, K.Sugimura: "MRI and Proton MRS of Prostate at 3.0 Tesla"Asia Pacific MR Symposium. 45 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 前田隆樹, 楫 靖, 木村ゆり, 杉村和朗, 黒田 輝, 藤原俊孝, 松田 豪, 塚元鉄二: "3テスラMR装置による前立腺Proton MRS:健常ボランティアでの検討"日本磁気共鳴医学会雑誌. 22S. 311-334A (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Kuroda, Y.Kaji, RV Mulkern, N.Takei, Y.Kitamura, M.Tamura, K.Sugimura: "MR Observations of Prostate Metabolites at 3 Tesla"Proc.10th Meeting ISMRM. 3. 1921 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Kuroda, N.Takei, Y.Kaji, K.Sugimura et al.: "Interventional MR Researches at The Institute of Biomedical Research and Innovation"Proc.LIST 2001,AIST-Kansai,Ikeda. 45 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 黒田 輝: "MRIによる物理計測がもたらすもの"映像医療メディカル. 2002-4(印刷中). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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