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血液網膜柵外方透過性機能検査法の確立とその糖尿病黄斑浮腫への応用

Research Project

Project/Area Number 13771007
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionAsahikawa Medical College

Principal Investigator

森 文彦  旭川医科大学, 医学部, 助手 (90322916)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords糖尿病 / 黄斑浮腫 / 血液網膜柵外方透過性 / differential vitreous fluorophotometry / differential fluorophotometry / 血液網膜柵外方透過性機能 / プロベネシド / アセタゾラミド
Research Abstract

糖尿病黄斑浮腫患者のdifferential vitreous fluorophotometry (DVF)による血液網膜柵外方透過性機能の検討
改良されたDVF(Fluorotron(TM)Master-2,OcuMetrics, Mountain View)で、硝子体のfluorescein (F)とその代謝産物であるfluorescein monoglucuronide (FG)濃度を測定した。fluorescein-Naを静脈注射後2時間後にDVFでF/FG比を算出し、これを血液網膜柵外方透過性機能の指標とした。対象は正常者群7名、糖尿病黄斑浮腫患者群6名、糖尿病黄斑浮腫なし患者群5名の3群とした。F/FG比は正常者群で0.42±0.32(0.13-0.95)、糖尿病黄斑浮腫患者群で2.84±1.20(1.13-4.12)、糖尿病黄斑浮腫なし患者群で0.50±0.34(0.10-0.80)であり、正常者群と糖尿病黄斑浮腫なし患者群に比較して、糖尿病黄斑浮腫患者群が有意に増加していた。したがって、糖尿病黄斑浮腫患者において、activetransportの低下が認められ、これがそのメカニズムの1つであることが示唆された。

Report

(2 results)
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Fumihiko Mori, et al.: "Dysfunction of Active Transport of Blood Retinal Barrier in Patients with Clinically Significant Macular Edema in Type 2 Diabetes"Diabetes Care. 25・7. 1248-1249 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fumihiko Mori, et al.: "Inhibitory Effect of Losartan, an AT1 angiotensin II receptor antagonist, on increased leucocyte entrapment in retinal microcirculation of diabetic rats"British Journal of Ophthalmology. 86・10. 1172-1174 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fumihiko Mori, et al.: "Use of scanning laser ophthalmoscope microperimetry in clinically significant macular edema in type 2 diabetes mellitus"Japanese Journal of Ophthalmology. 46・6. 650-655 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi J, Mori F, et, al: "Effect of acetazolamide on outward permeability of blood-retina barrier using differential vitreous fluorophotometry"Current Eye Research. 23・3. 166-170 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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