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Research for Creutzfeldt-Jakob Disease : vCJD

Research Project

Project/Area Number 13800006
Research Category

Grant-in-Aid for Special Purposes

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

KATO Nobumasa  The University of Tokyo, Facility of Neuropsychiatry, Professor, 医学部附属病院, 教授 (10106213)

Co-Investigator(Kenkyū-buntansha) ONODERA Takashi  The University of Tokyo, Faculty of Agriculture, Professor, 大学院・農学生命研究科, 教授 (90012781)
MOURI Shiro  Kyushu University, Graduate School of Medical Sciences, Professor, 大学院・医学研究科, 教授 (40117271)
IWAKI Toru  Kyushu University, Neuropathology, Professor, 大学院・医学研究科, 教授 (40221098)
HASHIMOTO Ohiko  Nagoya University Facility of Neuropsychiatry Assistant Professor, 大学院・医学研究科, 助教授 (90292911)
ARIMURA Kimiyoshi  Kagoshima University, Third Internal Medicine, Assistant Professor, 医学部, 助教授 (20159510)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 2002: ¥9,500,000 (Direct Cost: ¥9,500,000)
Keywordsvariant CJD / BSE / Ireland / tracking system
Research Abstract

The present research was intended to establish the early and definite diagnosis of BSE, the food safety control against possible contamination and the infection/risk control and safety management of the possible occurrence of human vCJD. In order to fulfil this purpose, the applicants and their cooperators visited the following Institutes and searched their activities on 2001/4 - 2003/3. 1) United Kingdom ; Edinburgh NCJDSU, London Institute of Neurology, 2) Ireland ; National Disease Surveillance Centre, 3) France ; National Surveillance Committee, Salpetriere Hospital, Bio Rad, 4) Netherlands ; BSE Center, 5) Germany ; University of Muenchen, 6) Italy ; University of Palermo, University of Rome, 7) United States ; National Institute of Health.
The results were summarized in this Report and presented in the International Symposium held in The University of Tokyo on November 25^<th>, 2002, which was organize by the applicant. In this Symposium, two distinguished guests from France were invited to present the current status of BSE and vCJD in France.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] 加藤 進昌, 金子 清俊, 湯浅龍彦, 木村暁夫, 郭 伸, 橋本 大彦, 小野寺 節, 樋口 輝彦: "変異型CJDをめぐって-精神科医が果たす役割-"脳と精神の医学. 13・2. 169-200 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sasaki K, Doh-ura K, Ironside WJ, Iwaki T: "Increased clusterin (apolipoprotein J) expression in human and mouse brains infected withtransmissible spongiform encephalopathies"Acta Neuropathol. 103. 199-208 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iida T, Doh-ura K, Kawashima T, Abe H, Iwaki T: "An atypical case of sporadic Creutzfeldt-Jakob disease with Parkinson's disease"Neuropathology. 21. 294-297 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawashima T, Doh-ura K, Ogomori K, Iwaki T: "Apoptotic bodies in the cerebellum of Japanese patients with Greutzfeldt-Jakob disease"Pathol. Int.. 51. 140-144 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Horiuchi H., Nemoto T., Ishiguro N., Furuoka H., Mohri S., Shinagawa M.: "Biological and biochemical characterization of sheep scrapie in Japan"J. Clin. Microbiol.. 40. 3421-3426 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 毛利資郎: "ヒト・プリオンのバイオアッセイ"臨床検査. 46. 1553-1558 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 毛利資郎: "プリオン病のモデル動物"神経進歩. 42(1). 54-58 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 毛利資郎, 北本哲之: "ヒト・プリオンバイオアッセイ法の新展開"第121回日本医学会シンポジウム記録集 プリオン病. 100-108 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小野寺 節: "日本のBSE"神経内科. 57. 391-397 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小野寺 節: "プリオンとは何か"獣医畜産進報. 55. 1029-1032 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小野寺 節: "プリオンとプリオン病"小児科. 44・3(印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小野寺 節, 作道 章一: "正常プリオン蛋白の機能"神経研究の進歩. 47. 7-17 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小野寺 節: "プリオンの遺伝子学、新世紀の感染症学"日本臨床. 61・3. 653-658 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小野寺 節, 作道 章一: "正常プリオン蛋白の機能、プリオン病(第121回日本医学会シンポジウム記録集)"協和企画. 121. 48-55 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 有村公良, 納 光弘, 橋口照人: "Vascular endothelial growth factor and Crow-Fukase syndrome"臨床神経学. 41(12). 1144-1146 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Arimura, Y.Sonoda, O.Watanabe et al.: "Isaacs' syndrome as a potassium channelopathy of the nerve"Muscle Nerve. Supple 11. 55-58 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Arimura, Y.Sonoda, O.Watanabe et al.: "Advances in Clinical Neurophysiology (Supplement to Clinical Neurophysiology Vol. 54)"Ion channel disorders in neuropathy. 6(527) (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato N., Kaneko K., Yuasa T., etc.: "Prespectives on variant Creutzfeldt-Jakob Disease(vCJD)-Role of Clinical Psychiatrists"Brain Science and Mental Disorders. 13(2). 169-200 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sasaki K, Doh-ura K, Ironside WJ, Iwaki T.: "Increased clusterin(apolipoprotein J) expression in human and mouse brains infected withtransmissible spongiform encephalopathies"Acta Neuropathol. 103. 199-208 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] lidaT, Doh-ura K, Kawashima T, Abe H, Iwaki T.: "An atypical case of sporadic Creutzfeldt-Jakob disease with Parkinson's disease"Neuropathology. 21. 294-297 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawashima T, Doh-ura K, Ogomori K, Iwaki T.: "Apoptotic bodies in the cerebellum of Japanese patients with Creutzfeldt-Jakob disease"Pathol. Int.. 51. 140-144 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Horiuchi, H., Nemoto, T., Ishiguro, N., Furuoka, H., Mohri, S. and Shinagawa, M.: "Biological and biochemical characterization of sheep scrapie in Japan"J. Clin. Microbiol.. 40(9). 3421-3426 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mohri S.: "Bioassay of human prion protein"Rinsyou Kensa. 46. 1553-1558 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mohri S.: "Mouse models of prion disease for highly sensitive detection of infectivity"Advances in Neurological Sciences. 47(1). 54-58 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tateishi J., Kitamoto T., Mohri S., Satoh S., Sato T., Shepherd A. and Macnaughton M R.: "Scrapie removal study using viral removal filter, PLANOVA"Biologicals. 100-108 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera T.: "Japanese BSE"Shinkei Naika. 57. 391-397 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera T.: "What is prion?"Jui Chikusan Shinpo. 55. 1029-1032 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera T.: "Prion and prion diseases"Shinkei Naika. 44(3), in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera, T. and Sakudo, A.: "Normal function of cellular isoform of prion protein"Shinkeikenkyu no Shinpo. 47. 7-17 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera, T.: "Molecular genetics of prion"Nihon Rinsho. 61(3). 653-658 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera T., Sakudo A.: "Normal function of PrPc."Proceedings of Japanese Medical Association Symposium. 121. 48-55 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arimura K, Osame, M, Hashuguchi T.: "Vascular endotbelial growth factor and Crow-Fukase syndrome"Clinical Neurology. 41(12). 1144-1146 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arimura K, Sonoda Y, Watanabe O, et al.: "Isaacs' syndrome as a potassium channelopathy of the nerve"Muscle Nerve Suppl. 11. 55-58 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arimura K, Sonoda Y, Watanabe O, et al.: "Ion channel disorders in neuropathy"Advances in Clinical Neurophysiobgy (Supplement to Clinical Neurophysiology). 54. 43-48 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 加藤 進昌, 金子 清俊, 湯浅龍彦, 木村暁夫, 郭 伸, 橋本 大彦, 小野寺 節, 樋口 輝彦: "変異型CJDをめぐって-精神科医が果たす役割-"脳と精神の医学. 13・2. 169-200 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sasaki K, Doh-ura K, Ironside WJ, Iwaki T: "Increased clusterin (apolipoprotein J) expression in human and mouse brains infected withtransmissible spongiform encephalopathies"Acta Neuropathol. 103. 199-208 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iida T, Doh-ura K, Kawashima T, Abe H, Iwaki T: "An atypical case of sporadic Creutzfeldt-Jakob disease with Parkinson's disease"Neuropathology. 21. 294-297 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawashima T, Doh-ura K, Ogomori K, Iwaki T: "Apoptotic bodies in the cerebellum of Japanese patients with Creutzfeldt-Jakob disease"Pathol. Int.. 51. 140-144 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Horiuchi H., Nemoto T., Ishiguro N., Furuoka H., Mohri S., Shinagawa M.: "Biological and biochemical characterization of sheep scrapie in Japan"J. Clin. Microbiol.. 40. 3421-3426 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 毛利資郎: "ヒト・プリオンのバイオアッセイ"臨床検査. 46. 1553-1558 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 毛利資郎: "プリオン病のモデル動物"神経進歩. 42(1). 54-58 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 毛利資郎, 北本哲之: "ヒト・プリオンのバイオアッセイ法の新展開"第121回日本医学会シンポジウム記録集 プリオン病. 100-108 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-23  

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