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Elucidation of activation mechanism for immune response in hyperthermia using MCL and application to cancer therapy

Research Project

Project/Area Number 13853005
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field 生物・生体工学
Research InstitutionChubu Univ. (2004-2005)
Nagoya University (2001-2003)

Principal Investigator

KOBAYASHI Takeshi  Chubu Univ., College of Bioscience and Biotechnology, Prof., 応用生物学部, 教授 (10043324)

Co-Investigator(Kenkyū-buntansha) WAKABAYASHI Toshihiko  Nagoya Univ., School of Medicine, Associate Prof., 医学部附属病院, 助教授 (50220835)
HONDA Hiroyuki  Nagoya Univ., School of Engineering, Prof., 大学院・工学研究科, 教授 (70209328)
ITO Akira  Kyushu Univ., School of Engineering, Associate Prof., 大学院・工学研究院, 助教授 (60345915)
新海 政重  東京大学, 大学院・工学系研究科, 講師 (70262889)
Project Period (FY) 2001 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥123,500,000 (Direct Cost: ¥95,000,000、Indirect Cost: ¥28,500,000)
Fiscal Year 2005: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2004: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2003: ¥30,030,000 (Direct Cost: ¥23,100,000、Indirect Cost: ¥6,930,000)
Fiscal Year 2002: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2001: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
KeywordsCancer therapy / Hyperthermia / Immune induction / Magnetic particles / Liposomes / Warming / リポソーム / マグネタイト / 腫瘍免疫 / 抗体 / HSP / メラノーマ / ヒートショックプロテイン / HSP70 / IL-2 / GM-CSF / 温熱免疫 / 交番磁界 / 誘電加温 / ヒートショックタンパク / MHCクラスI
Research Abstract

1.Hyperthermia using MCL for various carcinoma cells
Intracellular hyperthermia using magnetite cationic liposomes (MCL) was very effective for various carcinoma animal models (rabbit, hamster, rat and mouse).
2.Immune induction in lymph node using MCL-hyperthermia system
Selective hyperthermia using magnetoliposomes was found to induce immune responces in lymph node. Immune cells (NK cells, T cells and dendritic cells) were activated.
3.Targeting ability in tumor cells and intracellular hyperthermia using AML
Antibody-conjugated magnetoliposomes (AML) were developed. The monoclonal antibody to renal cell carcinoma was bound to the magnetoliposomes. This AML accumulated only renal cell carcinoma when AML was injected in vein, and intracellular hyperthermia was very effective.
4.Hyperthermia for human prostate cancer and hereditary melanoma in a mouse model
Heat can kill any cells. This was checked not only for mouse or rat carcinoma cells, but also for human prostate cancer and hereditary melanoma in a mouse model. Repeated hyperthermia was more effective compared with a single hyperthermia treatment.
5.Activation mechanisms for immune response in hyperthermia
By applying hyperthermia treatment, a lot of heat shock proteins were produced. Heat shock protein 70 chaperons tumor peptides, which induces immune response to the tumor.

Report

(6 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (87 results)

All 2006 2005 2004 2003 2002 2001 Other

All Journal Article (65 results) Book (2 results) Patent(Industrial Property Rights) (6 results) Publications (14 results)

  • [Journal Article] Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles : a novel concept of "heat-controlled necrosis" with heat shock protein expression2006

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology Immunotherapy 55

      Pages: 320-328

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles : a novel concept of "heat-controlled necrosis" with heat shock protein expression2006

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology Immunotherapy 55(3)

      Pages: 320-328

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles : a novel concenpt of "heat-controlled necrosis" with heat shock protein expression2006

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology Immunotherapy 55

      Pages: 320-328

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A mechanism of anititumor immunity induced by hyperthermia2005

    • Author(s)
      Akira Ito
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 21

      Pages: 1-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aniticancer effect of hyperthermia on prostate cancer mediated by magnitite cationic liposomes and immune-response induction in transplanted syngeneic rats2005

    • Author(s)
      Noriyasu Kawai
    • Journal Title

      The Prostate 64

      Pages: 373-381

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles2005

    • Author(s)
      Kouji Tanaka
    • Journal Title

      International Fournal of Cancer 116

      Pages: 624-633

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma2005

    • Author(s)
      Kouji Tanaka
    • Journal Title

      Journal of Bioscience and Bioengineering 100

      Pages: 112-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Screening of cytokines to enhance vaccine effects of heat shock protein 70-rich tumor cell lysate2005

    • Author(s)
      Akira Ito
    • Journal Title

      Journal of Bioscience and Bioengineering 100

      Pages: 36-42

    • NAID

      110002703740

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Medical application of functionalized magnetic nanoparticles2005

    • Author(s)
      Akira Ito
    • Journal Title

      Journal of Bioscience and Bioengineering 100

      Pages: 1-11

    • NAID

      110002703737

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Complete regression of hereditary melanoma in a mouse model by repeated hyperthermia using magnetite cationic Iiposomes2005

    • Author(s)
      Akira Ito
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 21

      Pages: 139-149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A mechanism of antitumor immunity induced by hyperthermia2005

    • Author(s)
      Akira Ito
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 21(1)

      Pages: 1-11

    • NAID

      10029676156

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplated syngeneic rats2005

    • Author(s)
      Noriyasu Kawai
    • Journal Title

      The Prostate (64)

      Pages: 373-381

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles2005

    • Author(s)
      Kouji Tanaka
    • Journal Title

      International Journal of Cancer 116

      Pages: 624-633

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma2005

    • Author(s)
      Kouji Tanaka
    • Journal Title

      Journal of Bioscience and Bioengineering 100(1)

      Pages: 112-115

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Screening of cytokines to enhance vaccine effects of heat shock protein 70-rich tumor cell lysate2005

    • Author(s)
      Akira Ito
    • Journal Title

      Journal of Bioscience and Bioengineering 100(1)

      Pages: 36-42

    • NAID

      110002703740

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Medical application of functionalized magnetic nanoparticles2005

    • Author(s)
      Akira Ito
    • Journal Title

      Journal of Bioscience and Bioengineering 100(1)

      Pages: 1-11

    • NAID

      110002703737

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Complete regression of hereditary melanoma in a mouse model by repeated hyperthermia using magnetite cationic liposomes2005

    • Author(s)
      Akira Ito
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 21(3)

      Pages: 169-149

    • NAID

      10029676417

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats2005

    • Author(s)
      Noriyasu Kawai
    • Journal Title

      The Prostate 64

      Pages: 373-381

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Intratumoral injection of immature dendritic cells enhances antitumor effect of hvperthermia using magnetic nanoparticles2005

    • Author(s)
      Kouji Tanaka
    • Journal Title

      International Journal of Cancer 116

      Pages: 624-633

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Complete regression of hereditary melanoma in a mouse model by repeated hyperthermia using magnetite cationic liposomes2005

    • Author(s)
      Akira Ito
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 21

      Pages: 139-149

    • NAID

      10029676417

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A Mechanism of Antitumor Immunity Induced by Hyperthermia2005

    • Author(s)
      Akira Ito et al.
    • Journal Title

      Japanese Journal of Hyperthermic Oncology In press

    • NAID

      10029676156

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles2005

    • Author(s)
      Kouji Tanaka et al.
    • Journal Title

      International Journal of Cancer In press

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Anititumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma2004

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology Immunotherapy 53

      Pages: 26-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma2004

    • Author(s)
      Fumiko Matsuoka
    • Journal Title

      BioMagnetic Reseach and Technology 2, 3

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 温熱療法に伴う免疫賦活のメカニズム2004

    • Author(s)
      小林 猛
    • Journal Title

      中部大学応用生物学紀要 3

      Pages: 39-45

    • NAID

      110004323756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of anitibody therapy with hyperthermia2004

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Letters 212

      Pages: 167-175

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anititumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma2004

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology Immunotherapy 53(1)

      Pages: 26-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma,2004

    • Author(s)
      Fumiko Matsuoka
    • Journal Title

      BioMagnetic Research and Technology 2:3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanism for immune induction in hyperthermia2004

    • Author(s)
      Takeshi Kobayashi
    • Journal Title

      Bulletin of Chubu Univ., School of Bioscience and Biotechnology 3

      Pages: 39-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia2004

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Letters (212)

      Pages: 167-175

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia.2004

    • Author(s)
      Akira Ito et al.
    • Journal Title

      Cancer Letters 212・2

      Pages: 167-175

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Heat shock protein 70 expression induces an anitumor immunity during intracellular hyperthemia using magnetite nanoparticles2003

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology Immunotherapy 52

      Pages: 80-88

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experiment subcutaneous murine melanoma2003

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Science 94

      Pages: 308-313

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anticancer effect and immune induction by hyperthemia of malignant melanoma using magnetite cationic liposomes2003

    • Author(s)
      Masataka Suzuki
    • Journal Title

      Melanoma Reseach 13

      Pages: 129-135

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Selective hyperthemia using magneliposomes to target cervical lymph mode metastasis in a rabbit tongue tumor model2003

    • Author(s)
      Shigeaki Hmaguchi
    • Journal Title

      Cancer Science 94

      Pages: 834-839

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Time course of biodistribution and heat generation of magnetite cationic liposomes in mouse model2003

    • Author(s)
      Akira Ito
    • Journal Title

      Japanese Journal of Hyperthemic Oncology 19

      Pages: 151-159

    • NAID

      10029675650

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Complete regression of mouse mammary carcinoma with a size greater than 15 mm by frequent repeated hyperthermia using magnetite nanoparticles2003

    • Author(s)
      Akira Ito
    • Journal Title

      Journal of Bioscience and Bioengineering 96

      Pages: 364-369

    • NAID

      110002665207

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat shock protein 70 gene tharapy combined with hyperthermia using magnetic nanoparticles2003

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Gene Therapy 10

      Pages: 918-925

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat shock protein 70 expression induces an antitumor immunity during intracellular hyperthermia using magnetite nanoparticles2003

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology Immunotherapy 52(2)

      Pages: 80-88

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma2003

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Science 94(3)

      Pages: 308-313

    • NAID

      50000783906

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anticancer effect and immune induction by hyperthermia of malignant melanoma using magnetite cationic liposomes2003

    • Author(s)
      Masataka Suzuki
    • Journal Title

      Melanoma Research 13(2)

      Pages: 129-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Selective hyperthermia using magnetoliposomes to target cervical lymph node metastasis in a rabbit tongue tumor model2003

    • Author(s)
      Shigeaki Hamaguchi
    • Journal Title

      Cancer Science 94(9)

      Pages: 834-839

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Time course of biodistribution and heat generation of magnetite cationic liposomes in mouse model2003

    • Author(s)
      Akira Ito
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 19(3)

      Pages: 151-159

    • NAID

      10029675650

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Complete regression of mouse mammary carcinoma with a size grater than 15 mm by frequent repeated hyperthermia using magnetite nanoparticles2003

    • Author(s)
      Akira Ito
    • Journal Title

      Journal of Bioscience and Bioengineering 96(4)

      Pages: 364-369

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles2003

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Gene Therapy 10(12)

      Pages: 918-925

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of functional magnetic particles on radiofrequency capacitive heating : an in vivo study2002

    • Author(s)
      Masashige Shinkai
    • Journal Title

      Japanese Journal of Cancer Reseach 93

      Pages: 103-108

    • NAID

      10008066322

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of particulate heating mediator in RF capacitive heating2002

    • Author(s)
      Masashige Shinkai
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 18

      Pages: 33-40

    • NAID

      10029675145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effective solitary hyperthermia treatment of maglignant glioma using stick type CMC-magnetite. In vivo study2002

    • Author(s)
      Takanari Ohno
    • Journal Title

      Journal of Neuro-Oncology 56

      Pages: 233-239

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Magnetite needle as heating mediator for intracellular hyperthermia of tumor2002

    • Author(s)
      Masashige Shinkai
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 18

      Pages: 191-198

    • NAID

      10029675390

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of functional magnetic particles on radiofrequency capacitive heating : an in vivo study2002

    • Author(s)
      Masashige Shinkai
    • Journal Title

      Japanese Journal of Cancer Research 93(1)

      Pages: 103-108

    • NAID

      10008066322

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of particulate heating mediator in RF capacitive heating2002

    • Author(s)
      Masashige Shinkai
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 18(1)

      Pages: 33-40

    • NAID

      10029675145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effective solitary hyperthermia treatment of maglignant glioma using stick type CMC-magnetite. In vivo study2002

    • Author(s)
      Takanari Ohno
    • Journal Title

      Journal of Neuro-Oncology 56(5)

      Pages: 233-239

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Magnetite needle as heating mediator for intracellular hyperthermia of tumor2002

    • Author(s)
      Masashige Shinkai
    • Journal Title

      Japanese Journal of Hyperthermia Oncology 18(4)

      Pages: 191-198

    • NAID

      10029675390

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Preparation of tumaor-specific magnetoliposomes and their application for hyperthermia2001

    • Author(s)
      Biao Le
    • Journal Title

      Journal of Chemical Engineering of Japan 34

      Pages: 66-72

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interstitial hyperthermia using magnetite cationic liposomes inhibit to tumor growth of VX-7 transplanted tumor in rabbit tongue2001

    • Author(s)
      Hideyuki Matsuno
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 17

      Pages: 141-149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat-inducible TNF-α gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy2001

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Gene Therapy 8

      Pages: 649-654

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Targeting hyperthermia for renal cell carcinima using human MN anigen-special magnetoliposomes2001

    • Author(s)
      Akira Ito
    • Journal Title

      Japanese Journal of Cancer Reseach 92

      Pages: 1138-1145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Radiation-inducible TNF-α gene expression under stress-inducible promoter gadd153 for cancer therapy2001

    • Author(s)
      Akira Ito
    • Journal Title

      Journal of Bioscience and Bioengineering 92

      Pages: 598-601

    • NAID

      110002683969

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia2001

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology and Immunotherapy 50

      Pages: 515-522

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Preparation of tumor-specific magnetoliposomes and their application for hyperthermia2001

    • Author(s)
      Biao Le
    • Journal Title

      Journal of Chemical Engineering of Japan 34(1)

      Pages: 66-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interstitial hyperthermia using magnetite cationic liposomes inhibit to tumor growth of VX-7 transplanted tumor in rabbit tongue2001

    • Author(s)
      Hideyuki Matsuno
    • Journal Title

      Japanese Journal of Hyperthermic Oncology 17(3)

      Pages: 141-149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat-inducible TNF-α gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy2001

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Gene Therapy 8(9)

      Pages: 649-654

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Targeting hyperthermia for renal cell carcinoma using human MN antigen-specific magnetoliposomes2001

    • Author(s)
      Masashige Shinkai
    • Journal Title

      Japanese Journal of Cancer Research 92(10)

      Pages: 1138-1145

    • NAID

      50000984502

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Radiation-inducible TNF-α gene expression under stress-inducible promoter gadd153 for cancer therapy2001

    • Author(s)
      Akira Ito
    • Journal Title

      Journal of Bioscience and Bioengineering 92(6)

      Pages: 598-601

    • NAID

      110002683969

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia2001

    • Author(s)
      Akira Ito
    • Journal Title

      Cancer Immunology and Immunotherapy 50(10)

      Pages: 515-522

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Recent Progress of Biochemical and Biomedical Engineering in Japan II, Advances in Biochemical Engineering/Biotechnology(Edited by Takeshi Kobayashi)2004

    • Author(s)
      Masashige Shinkai
    • Publisher
      Springer-Verlag
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Functional Magnetic Particles for Medical Application, Recent Progress of Biochemical and Biomedical Engineering in Japan II(Ed.T.Kobayashi)2004

    • Author(s)
      Masashige Shinkai et al.
    • Publisher
      Springer-Verlag
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗HMW-MAA抗体を結合した磁性微粒子を含むリボソーム2005

    • Inventor(s)
      小林 猛, 井藤 彰, 本多裕之, 斎田俊明
    • Industrial Property Rights Holder
      小林 猛, ナノセラピー研究所
    • Industrial Property Number
      2005-093846
    • Filing Date
      2005-03-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 免疫賦活剤2004

    • Inventor(s)
      小林 猛, 井藤 彰, 本多裕之
    • Industrial Property Rights Holder
      小林 猛, TTC CO.
    • Filing Date
      2004-02-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 新規リボソーム2004

    • Inventor(s)
      井藤 彰, 本多裕之, 小林 猛
    • Industrial Property Rights Holder
      井藤 彰, 本多裕之, 小林 猛
    • Industrial Property Number
      2004-049423
    • Filing Date
      2004-02-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] Hypertheermia agent for malignant tumor comprising cytokine and magnetic fine particles2004

    • Inventor(s)
      Akira Ito, Hitoyuki Honda, Takeshi Kobayashi
    • Industrial Property Rights Holder
      小林 猛, TTC Co., ナノセラピー研究所
    • Filing Date
      2004-07-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 熱ショックタンパク質と磁気微粒子からなる悪性腫瘍の温熱治療剤2003

    • Inventor(s)
      小林 猛, 井藤 彰, 本多裕之
    • Industrial Property Rights Holder
      小林 猛, TTC Co.
    • Filing Date
      2003-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 磁石配置方法及び磁気誘導方法2001

    • Inventor(s)
      小林 猛, 新海政重, 本多裕之, 瀧 千智
    • Industrial Property Rights Holder
      名古屋大学学長
    • Filing Date
      2001-06-06
    • Acquisition Date
      2003-07-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Akira Ito et al.: "Time course of biodistribution and heat generation of magnetite cationic liposomes in mouse model"Japanese Journal of Hyperthermic Oncology. 19・3. 151-159 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akira Ito et al.: "Complete regression of mouse mammary carcinoma with a size greater than 15 mm by frequent repeated hyperthermia using magnetite nanoparticles"Journal of Bioscience and Bioengineering. 96・4. 364-369 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akira Ito et al.: "Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles"Cancer Gene Therapy. 10・12. 918-925 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akira Ito et al.: "Anititumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma"Cancer Immunology Immunotherapy. 53・1. 26-32 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masashige Shinkai: "Characteristics of particulate heating mediator in RF capacitive heating"Japanese Journal of Hyperthermic Oncology. 18・1. 33-40 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masashige Shinkai: "Effect of functional magnetic particles on radiofrequency capacitive heating : an in vivo study"Japanese Journal of Cancer Research. 93・1. 103-108 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akira Ito 他: "Transglutaminase-mediated gelatin matrices incorporating cell adhesion factors as a biomaterial for tissue engineering"Journal of Bioscience and Bioengineering. 95・2. 196-199 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akira Ito 他: "Heat shock protein 70 expression induces an antitumor immunity during intracellular hyperthermia using magnetite nanoparticles"Cancer Immunology Immunotherapy. 52・1. 80-88 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akira Ito 他: "Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma"Cancer Science. 94・3. 308-313 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masataka Suzuki 他: "Anti-cancer effect and immune induction by hyperthermia of malignant melanoma using magnetite cationic liposomes"Melanoma Research. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akira Ito 他: "Radiation-inducible TNF-α gene expression under stress-inducible promoter gadd153 for cancer therapy"Journal of Bioscience and Bioengineering. 92・6. 598-601 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masashige Shinkai 他: "Effect of functional magnetic particles on radiofrequency capacitive heating : an in vivo study"Japanese Journal of Cancer Research. 93・1. 103-108 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akira Ito 他: "Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia"Cancer Immunology and Immunotherapy. 50・10. 515-522 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masashige Shinkai 他: "Targeting hyperthermia for renal cell carcinoma using human MN antigen-specific magnetoliposomes"Japanese Journal of Cancer Research. 92・10. 1138-1145 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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