Integrated analyses of biological functions of sugar chains : Glycomics

• Project/Area Number: 13854010
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Osaka University
• Principal Investigator: TANIGUCHI Naoyuki Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (90002188)
• Co-Investigator(Kenkyū-buntansha): MIYOSHI Eiji Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (20322183) ; HONKE Koichi Kochi University, Faculty of Medicine, Professor, 医学部, 教授 (80190263) ; JIANGUO Gu Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (40260369) ; BUNGYOKU Tei Saga University, Faculty of Medicine, Professor, 医学部, 教授 (60252657) ; TAKAHASHI Motoko Saga University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (00303941)
• Project Period (FY): 2001 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥122,980,000 (Direct Cost: ¥94,600,000、Indirect Cost: ¥28,380,000); Fiscal Year 2005: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2004: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2003: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000); Fiscal Year 2002: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000); Fiscal Year 2001: ¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
• Keywords: sugar chain / glycosyltransferase / matriptase / GnT-III / GnT-V / Fut 8 / adhesion molecule / growth factor receptor / がん転移 / 糖鎖生物学 / プロテアーゼ / 発生・分化 / グライコミクス / 再生医療 / 血管新生 / アポトーシス / 硫酸化転移酵素 / EGF受容体 / がんの転移 / βカテニン / 異種移植

Research Abstract

To know biological functions of sugar chain by integrated analyses, we have identified target glycoproteins of specific glycosyltransferases as follows.
GnT-V catalyses the synthesis of beta 1-6 GlcNAc branching which involves inn tumor metastasis and invasion. In this project, we identified matriptase as a target molecule of GnT-V, which can activate uPA, and HGF. Addition of betal-6 GlcNAc branching on matriptase brought prolonged degradation of these proteins, leading to tumor metastasis in nude mice experiments.
Cadherin and integrin are target molecules for GnT-III which involves in the synthesis of bisecting GlcNAc structure. Bisecting GlcNAc inhibit further processing of N-glycan elongation via GnT-V or GnT-IV. In this project, biological functions of sugar chains on integrin and ECM interaction were clarified as a level of purified molecules. Cadherin/beta catenin system is also regulated by GnT-III. Phosphorylation of beta-catenin is suppressed by GnT-III and expression of e-cadherin is controlled by GnT-III
Fut8 involves in core fucosylation on N-glycans. To know physiological meaning of Fut8, we established Fut8 deficient mice. This mouse shows severe growth retardation and 70% of mice die within 3 days after birth. Interestingly, pathological analysis showed emphysema-like lesion in lung of the mice. The mechanism underlying this change is due to dys-regulation of TGF beta-receptor, leading to increases in MMP expression.

Research Products

• [Journal Article] Core fucosylation regulates epidermal 9「owth factor receptor-mediated intracellular signaling. (2006)
  • Author(s): Wang X et al.
  • Journal Title: J Biol Chem 281 Pages: 2572-2577
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Reaction mechanism and substrate specificity for nucleotide sugar of mammalian alpha1, 6-fucosyltransferase--a large-scale preparation and characterization of recombinant human FUT8. (2006)
  • Author(s): Ihara H et al.
  • Journal Title: Glycobiology 16 Pages: 333-342
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fucosylated haptoglobin is a novel marker for pancreatic cancer : a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation. (2006)
  • Author(s): Okuyama N et al.
  • Journal Title: Int J Cancer 118 Pages: 2803-2808
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain. (2006)
  • Author(s): Inamori K et al.
  • Journal Title: Biochim Biophys Acta 1760 Pages: 678-684
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Loss of core fucbsylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insulin-like growth factor-binding protein 3 in fut8-/- mice. (2006)
  • Author(s): Lee SH et al.
  • Journal Title: J Biochem (Tokyo) 139 Pages: 391-398
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. (2006)
  • Author(s): Ide Y et al.
  • Journal Title: Biochem Biophys Res Commun 341 Pages: 478-482
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High expression of N-acetylglucosaminyltransferase V in favorable neuroblastomas : Involvement of its effect on apoptosis. (2006)
  • Author(s): Inamori K et al.
  • Journal Title: FEBS Lett 580 Pages: 627-632
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A specific detection of GlcNAc{beta} 1-6Man {alpha} 1 branches in N-linked glycoproteins based on the specificity of N-acetvlalucosaminvltransferase VI. (2006)
  • Author(s): Watanabe T et al.
  • Journal Title: Glycobiology 16 Pages: 431-439
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues--its possible role in prolonged stability in vivo by aberrant glycosylation. (2006)
  • Author(s): Ito Y et al.
  • Journal Title: Glycobiology 16 Pages: 368-374
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. (2006)
  • Author(s): Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, S.H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, S.D., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K., Taniguchi, N.
  • Journal Title: J Biol Chem 281 Pages: 2572-2577
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reaction mechanism and substrate specificity for nucleotide sugar of mammalian alpha1,6-fucosyltransferase--a large-scale preparation and characterization of recombinant human FUT8. (2006)
  • Author(s): Ihara, H., Ikeda, Y., Taniguchi, N.
  • Journal Title: Glycobiology 16 Pages: 333-342
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fucosylated haptoglobin is a novel marker for pancreatic cancer : a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation. (2006)
  • Author(s): Okuyama, N., Ide, Y., Nakano, M., Nakagawa, T., Yamanaka, K., Moriwaki, K., Murata, K., Ohigashi, H., Yokoyama, S., Eguchi, H., Ishikawa, O., Ito, T., Kato, M., Kasahara, A., Kawano, S., Gu, J., Taniguchi, N., Miyoshi, E.
  • Journal Title: Int J Cancer 118 Pages: 2803-2808
  • NAID: 130006995325
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain. (2006)
  • Author(s): Inamori, K., Mita, S., Gu, J., Mizuno-Horikawa, Y., Miyoshi, E., Dennis, J.W., Taniguchi, N.
  • Journal Title: Biochim Biophys Acta 1760 Pages: 678-684
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Loss of core fucosylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insulin-like growth factor-binding protein 3 in fut8-/-mice. (2006)
  • Author(s): Lee, S.H., Takahashi, M., Honke, K., Miyoshi, E., Osumi, D., Sakiyama, H., Ekuni, A., Wang, X., Inoue, S., Gu, J., Kadomatsu, K.., Taniguchi, N.
  • Journal Title: J Biochem (Tokyo) 139 Pages: 391-398
  • NAID: 10018846392
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. (2006)
  • Author(s): Ide, Y., Miyoshi, E., Nakagawa, T., Gu, J., Tanemura, M., Nishida, T., Ito, T., Yamamoto, H., Kozutsumi, Y., Taniguchi, N.
  • Journal Title: Biochem Biophys Res Commun 341 Pages: 478-482
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High expression of N-acetylglucosaminyltransferase V in favorable neuroblastomas : Involvement of its effect on apoptosis. (2006)
  • Author(s): Inamori K, Gu J, Ohira M, Kawasaki A, Nakamura Y, Nakagawa T, Kondo A, Miyoshi E, Nakagawara A, Taniguchi N.
  • Journal Title: FEBS Lett 580 Pages: 627-632
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A specific detection of GlcNAc {beta} 1-6Man {alpha} 1 branches in N-linked glycoproteins based on the specificity of N-acetylglucosaminyltransferase VI. (2006)
  • Author(s): Watanabe, T., Ihara, H., Miyoshi, E., Honke, K., Taniguchi, N., Taguchi, T.
  • Journal Title: Glycobiology 16 Pages: 431-439
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues--its possible role in prolonged stability in vivo by aberrant glycosylation. (2006)
  • Author(s): Ito, Y., Akinaga, A., Yamanaka, K., Nakagawa, T., Kondo, A., Dickson, R.B., Lin, C.Y., Miyauchi, A., Taniguchi, N., Miyoshi, E.
  • Journal Title: Glycobiology 16 Pages: 368-374
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High expression of N-acetylglucosaminyltransferase V in favorable neuroblastomas : Involvement of its effect on apoptosis. (2006)
  • Author(s): Kei-ichiro Inamori
  • Journal Title: FEBS Lett. 580 Pages: 627-632
• [Journal Article] Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. (2006)
  • Author(s): Yoshihito Ide
  • Journal Title: Biochem.Biophys.Res.Commun. 341 Pages: 478-482
• [Journal Article] Identification of target proteins of N-acetylglucosaminyl transferase V in human colon cancer and implications of protein tyrosine phosphatase kappa in enhanced cancer cell migration. (2006)
  • Author(s): Yong-Sam Kim
  • Journal Title: Proteomics 6 Pages: 1187-1191
• [Journal Article] Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain. (2006)
  • Author(s): Kei-ichiro Inamori
  • Journal Title: Biochem.Biophys.Acta (In press)
• [Journal Article] Fucosylated haptoglobin is a novel marker for pancreatic cancer : A detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation. (2006)
  • Author(s): Noriko Okuyama
  • Journal Title: Int.J.Cancer 108(In press)
• [Journal Article] Reaction Mechanism and Substrate Specificity for Nucleotide-Sugar of Mammalian {alpha}1,6-Fucosyltransferase (2006)
  • Author(s): Hideyuki Ihara
  • Journal Title: Glycobiology (In press)
• [Journal Article] {beta}1,4-N-Acetylglucosaminyltransferase III potentiates {beta}1 integrin-mediated neuritogenesis induced by serum deprivation in Neuro2a cells. (2006)
  • Author(s): Masaki Shigeta
  • Journal Title: Glycobiology (In press)
• [Journal Article] A specific detection of GIcNAc{beta}1-6Man{alpha}1 branches in N-linked glycoproteins based on the specificity of N-acetylglucosaminyltransferase VI. (2006)
  • Author(s): Tae Watanabe
  • Journal Title: Glycobiology (In press)
• [Journal Article] Co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues ; its possible role in prolonged stability in vivo by aberrant glycosylation. (2006)
  • Author(s): Yasuhiro Ito
  • Journal Title: Glycobiology (In press)
• [Journal Article] Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis. (2005)
  • Author(s): Zhang Y et al.
  • Journal Title: Glycobiology 15 Pages: 649-654
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Production of a recombinant single-chain variable-fragment (scFv) antibody against sulfoglycolipid. (2005)
  • Author(s): Cheng X et al.
  • Journal Title: J Biochem (Tokyo) 137 Pages: 415-421
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Bisecting GlcNAc mediates the binding of annexin V to Hsp47. (2005)
  • Author(s): Gao CX et al.
  • Journal Title: Glycobiology 15 Pages: 1067-1075
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion. (2005)
  • Author(s): Eguchi H et al.
  • Journal Title: Glycobiology 15 Pages: 1094-1101
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. (2005)
  • Author(s): Wang X et al.
  • Journal Title: Proc Natl Acad Sci U S A 102 Pages: 15791-15796
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of N-acetylglucosaminyltransferase V in the development of human esophageal cancers : immunohistochemical data from carcinomas and nearby noncancerous lesions. (2005)
  • Author(s): Ishibashi Y et al.
  • Journal Title: Oncology 69 Pages: 301-310
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta. (2005)
  • Author(s): Tomiie M et al.
  • Journal Title: Biochem Biophys Res Commun 330 Pages: 999-1004
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase. (2005)
  • Author(s): Kitazume S et al.
  • Journal Title: J Biol Chem 280 Pages: 8589-8595
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis. (2005)
  • Author(s): Zhang Y, Hayashi Y, Cheng X, Watanabe T, Wang X, Taniguchi N, Honke K.
  • Journal Title: Glycobiology 15 Pages: 649-654
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Production of a recombinant single-chain variable-fragment (scFv) antibody against sulfoglycolipid. (2005)
  • Author(s): Cheng, X., Zhang, Y., Kotani, N., Watanabe, T., Lee, S., Wang, X., Kawashima, I., Tai, T., Taniguchi, N., Honke, K.
  • Journal Title: J Biochem (Tokyo) 137 Pages: 415-421
  • NAID: 10017344246
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bisecting GlcNAc mediates the binding of annexin V to Hsp47. (2005)
  • Author(s): Gao, C.X., Miyoshi, E., Uozumi, N., Takamiya, R., Wang, X., Noda, K., Gu, J., Honke, K., Wada, Y., Taniguchi, N.
  • Journal Title: Glycobiology 15 Pages: 1067-1075
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion. (2005)
  • Author(s): Eguchi, H., Ikeda, Y., Ookawara, T., Koyota, S., Fujiwara, N., Honke, K., Wang, P.G., Taniguchi, N., Suzuki, K.
  • Journal Title: Glycobiology 15 Pages: 1094-1101
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. (2005)
  • Author(s): Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, S.H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, S.D., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K., Taniguchi, N.
  • Journal Title: Proc Natl Acad Sci USA 102 Pages: 15791-15796
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of N-acetylglucosaminyltransferase V in the development of human esophageal cancers : immunohistochemical data from carcinomas and nearby noncancerous lesions. (2005)
  • Author(s): Ishibashi, Y., Dosaka-Akita, H., Miyoshi, E., Shindoh, M., Miyamoto, M., Kinoshita, I., Miyazaki, H., Itoh, T., Kondo, S., Nishimura, M., Taniguchi, N.
  • Journal Title: Oncology 69 Pages: 301-310
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta. (2005)
  • Author(s): Tomiie, M., Isaka, S., Miyoshi, E., Taniguchi, N., Kimura, T., Ogita, K., Tsutsui, T., Shimoya, K., Nakagawa, T., Kondo, A., Koyama, M., Murata, Y.
  • Journal Title: Biochem Biophys Res Commun 330 Pages: 999-1004
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase. (2005)
  • Author(s): Kitazume, S., Nakagawa, K., Oka, R., Tachida, Y., Ogawa, K., Luo, Y., Citron, M., Shitara, H., Taya, C., Yonekawa, H., Paulson, J.C., Miyoshi, E., Taniguchi, N., Hashimoto, Y.
  • Journal Title: J Biol Chem 280 Pages: 8589-8595
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Core fucosylation regulates EGF receptor-mediated intracellular signaling. (2005)
  • Author(s): Xiangchun Wang
  • Journal Title: J Biol Chem 281(5) Pages: 2572-2577
• [Journal Article] Different immunoreactivity against monoclonal antibodies between wild-type and mutant copper/zinc superoxide dismutase linked to amyotrophic lateral sclerosis. (2005)
  • Author(s): Noriko Fujiwara
  • Journal Title: J Biol Chem 280(6) Pages: 5061-5070
• [Journal Article] Bisecting GIcNAc Mediates the Binding of Annexin V to Hsp47. (2005)
  • Author(s): Cong-xiao Gao
  • Journal Title: Glycobiology 15(11) Pages: 1067-1075
• [Journal Article] In vivo cleavage of alpha 2,6-sialyltransferase by Alzheimer's beta -secretase. (2005)
  • Author(s): Shinobu Kitazume
  • Journal Title: J Biol Chem 280(9) Pages: 6589-6595
• [Journal Article] Dysregulation of TGF-(β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. (2005)
  • Author(s): Xiangchun Wang
  • Journal Title: Proc.Natl.Acad.Sci.U S A 102(4) Pages: 15791-15796
• [Journal Article] Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis (2005)
  • Author(s): Yanlong Zhang
  • Journal Title: Glycobiology 15 Pages: 649-654
• [Journal Article] Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion (2005)
  • Author(s): Hironobu Eguchi
  • Journal Title: Glycobiology 15 Pages: 1094-1101
• [Journal Article] Expression of N-acetylglucosaminyltransferase V in the development of human esophageal cancers : immunohistochemical data from carcinomas and nearby noncancerous lesions (2005)
  • Author(s): Yoko Ishibashi
  • Journal Title: Oncology 69 Pages: 301-310
• [Journal Article] Elevated expression of N-acetylglucosaminyltramsferase V in the first trimester human placenta. (2005)
  • Author(s): Mari Tomiie
  • Journal Title: Biochem.Biophys.Res.Commun. 330 Pages: 999-1004
• [Journal Article] Overexpression of mutated Cu, Zn-SOD in neuroblastoma cells results in cytoskeletal change. (2005)
  • Author(s): Takamiya R.
  • Journal Title: Am.J.Physiol.Cell Physiol. 288
• [Journal Article] Optimization of liver biopsy RNA sampling and use of reference RNA for cDNA microarray analysis. (2005)
  • Author(s): Takemura F.
  • Journal Title: Anal.Biochem. 337 Pages: 224-234
• [Journal Article] Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells. (2005)
  • Author(s): Park Y.S.
  • Journal Title: Biochem.Biophys.Res.Commun. 327 Pages: 1058-1065
• [Journal Article] In vivo cleavage of alpha 2,6-sialyltransferase by Alzheimer's beta-secretase. (2005)
  • Author(s): Kitazume S.
  • Journal Title: J.Biol.Chem. 280 Pages: 8589-8595
• [Journal Article] Different Immunoreactivity against Monoclonal Antibodies between Wild-type and Mutant Copper/Zinc Superoxide Dismutase. Linked to Amyotrophic Lateral Sclerosis. (2005)
  • Author(s): Fujiwara N.
  • Journal Title: J.Biol.Chem. 280 Pages: 5061-5070
• [Journal Article] Addition of beta1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against (2004)
  • Author(s): Ihara S et al.
  • Journal Title: Glycobiology 14 Pages: 139-146
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Beta1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells. (2004)
  • Author(s): Gu J et al.
  • Journal Title: Glycobiology 14 Pages: 177-186
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain 0-mannosyl glycan. (2004)
  • Author(s): Inamori K et al.
  • Journal Title: J Biol Chem 279 Pages: 2337-2340
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. (2004)
  • Author(s): Isaji T et al.
  • Journal Title: J Biol Chem 279 Pages: 19747-19754
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers. (2004)
  • Author(s): Dosaka-Akita H et al.
  • Journal Title: Clin Cancer Res 10 Pages: 1773-1779
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of N-glycans in growth factor signaling. (2004)
  • Author(s): Takahashi M et al.
  • Journal Title: Glycoconj J 20 Pages: 207-212
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lactosylsulfatide expression in hepatocellular carcinoma cells enhances cell adhesion to vitronectin and intrahepatic metastasis in nude mice. (2004)
  • Author(s): Zhong Wu X et al.
  • Journal Title: Int J Cancer 110 Pages: 504-510
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulation of integrin functions by N-glycans. (2004)
  • Author(s): Gu J et al.
  • Journal Title: Glycoconj J 21 Pages: 9-15
  • NAID: 110006242860
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Biological roles of sulfoglycolipids and pathophysiology of their deficiency. (2004)
  • Author(s): Honke K et al.
  • Journal Title: Glycoconj J 21 Pages: 59-62
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional glycomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransf erases involved in N-glycan biosynthesis : their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer. (2004)
  • Author(s): Taniguchi N et al.
  • Journal Title: Proc.Jpn.Acad.Ser.B 80 Pages: 82-91
  • NAID: 130000093762
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis. (2004)
  • Author(s): Nakano N et al.
  • Journal Title: J Biol Chem 279 Pages: 11465-11470
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction. (2004)
  • Author(s): Ogawa D et al.
  • Journal Title: J Biol Chem 279 Pages: 2085-2090
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Attachment of human colon cancer cells to vascular endothelium is enhanced by N-acetylglucosaminyltransferase (2004)
  • Author(s): Murata K et al.
  • Journal Title: Oncology 66 Pages: 492-501
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Addition of betal-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin. (2004)
  • Author(s): Ihara, S., Miyoshi, E., Nakahara, S., Sakiyama, H., Ihara, H., Akinaga, A., Honke, K., Dickson, R.B., Lin, C.Y., Taniguchi, N.
  • Journal Title: Glycobiology 14 Pages: 139-146
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Betal,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells. (2004)
  • Author(s): Gu, J., Zhao, Y., Isaji, T., Shibukawa, Y., Ihara, H., Takahashi, M., Ikeda, Y., Miyoshi, E., Honke, K.., Taniguchi, N.
  • Journal Title: Glycobiology 14 Pages: 177-186
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. (2004)
  • Author(s): Inamori, K., Endo, T., Gu, J., Matsuo, I., Ito, Y., Fujii, S., Iwasaki, H., Narimatsu, H., Miyoshi, E., Honke, K.., Taniguchi, N.
  • Journal Title: J Biol Chem 279 Pages: 2337-2340
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Introduction of bisecting GlcNAc into integrin alpha5betal reduces ligand binding and down-regulates cell adhesion and cell migration. (2004)
  • Author(s): Isaji, T., Gu, J., Nishiuchi, R, Zhao, Y., Takahashi, M., Miyoshi, E., Honke, K., Sekiguchi, K.., Taniguchi, N.
  • Journal Title: J Biol Chem 279 Pages: 19747-19754
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers. (2004)
  • Author(s): Dosaka-Akita, H., Miyoshi, E., Suzuki, O., Itoh, T., Katoh, H., Taniguchi, N.
  • Journal Title: Clin Cancer Res 10 Pages: 1773-1779
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of N-glycans in growth factor signaling. (2004)
  • Author(s): Takahashi, M., Tsuda, T., Ikeda, Y., Honke, K.., Taniguchi, N.
  • Journal Title: Glycoconj J 20 Pages: 207-212
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lactosylsulfatide expression in hepatocellular carcinoma cells enhances cell adhesion to vitronectin and intrahepatic metastasis in nude mice. (2004)
  • Author(s): Zhong Wu, X., Honke, K., Long Zhang, Y., Liang Zha, X., Taniguchi, N.
  • Journal Title: Int J Cancer 110 Pages: 504-510
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of integrin functions by N-glycans. (2004)
  • Author(s): Gu, J., Taniguchi, N.
  • Journal Title: Glycoconj J 21 Pages: 9-15
  • NAID: 110006242860
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Biological roles of sulfoglycolipids and pathophysiology of their deficiency. (2004)
  • Author(s): Honke, K., Zhang, Y., Cheng, X., Kotani, N., Taniguchi, N.
  • Journal Title: Glycoconj J 21 Pages: 59-62
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional glycomics and evidence for gain-and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis : their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer. (2004)
  • Author(s): Taniguchi, N, Gu, J, Takahashi, M, Miyoshi, E.
  • Journal Title: Proc.Jpn.Acad.Ser.B 80 Pages: 82-91
  • NAID: 130000093762
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis. (2004)
  • Author(s): Nakano, N., Higashiyama, S., Ohmoto, H., Ishiguro, H., Taniguchi, N., Wada, Y.
  • Journal Title: J Biol Chem 279 Pages: 11465-11470
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction. (2004)
  • Author(s): Ogawa, D., Shikata, K., Honke, K., Sato, S., Matsuda, M., Nagase, R., Tone, A., Okada, S., Usui, H., Wada, J., Miyasaka, M., Kawashima, H., Suzuki, Y., Suzuki, T., Taniguchi, N., Hirahara, Y., Tadano-Aritomi, K., Ishizuka, I., Tedder, T.F., Makino, H.
  • Journal Title: J Biol Chem 279 Pages: 2085-2090
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Attachment of human colon cancer cells to vascular endothelium is enhanced by N-acetylglucosaminyltransferase V. (2004)
  • Author(s): Murata, K., Miyoshi, E., Ihara, S., Noura, S., Kameyama, M., Ishikawa, O., Doki, Y., Yamada, T., Ohigashi, H., Sasaki, Y., Higashiyama, M., Tarui, T., Takada, Y., Kannagi, R., Taniguchi, N., Imaoka, S.
  • Journal Title: Oncology 66 Pages: 492-501
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of N-acetylglucosaminyltransferase V is associated with prognosis and histology in non-small cell lung cancers (2004)
  • Author(s): Dosaka-Akita H.
  • Journal Title: Clin.Cancer Res. 10 Pages: 1773-1779
• [Journal Article] Addition of betal-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin. (2004)
  • Author(s): Ihara S.
  • Journal Title: Glycobiology 14 Pages: 139-146
• [Journal Article] Betal,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells. (2004)
  • Author(s): Gu J.
  • Journal Title: Glycobiology 14 Pages: 177-186
• [Journal Article] Lactosylsulfatide expression in hepatocellular carcinoma cells enhances cell adhesion to vitronectin and intrahepatic metastasis in nude mice. (2004)
  • Author(s): Wu X.Z.
  • Journal Title: Int.J.Cancer 110 Pages: 504-510
• [Journal Article] Sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction. (2004)
  • Author(s): Ogawa D.
  • Journal Title: J.Biol.Chem. 279 Pages: 2085-2090
• [Journal Article] N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man α 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. (2004)
  • Author(s): Inamori K.
  • Journal Title: J.Biol.Chem. 279 Pages: 2337-2340
• [Journal Article] γ-Glutamyl Transpeptidase Stimulates RANKL Expression Independent of Its Enzymatic activity and Serves as a Pathological Bone resorbing Factor. (2004)
  • Author(s): Niida S.
  • Journal Title: J.Biol.Chem. 279 Pages: 5752-5756
• [Journal Article] The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis. (2004)
  • Author(s): Nakano N.
  • Journal Title: J.Biol.Chem. 279 Pages: 11465-11470
• [Journal Article] Introduction of bisecting GlcNAc into integrin alpha5betal reduces ligand binding and down-regulates cell adhesion and cell migration. (2004)
  • Author(s): Isaji T.
  • Journal Title: J.Biol.Chem. 279 Pages: 19747-19754
• [Journal Article] Functional glycomics and evidence for gain-and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis : their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer-Review. (2004)
  • Author(s): Taniguchi N.
  • Journal Title: Proc.Japan Acad., Ser B 80 Pages: 82-91
• [Journal Article] Identification of target proteins of N-acetylglucosaminyl-transferase V and fucosyltransferase 8 in human gastric tissues by glycomic approach. (2004)
  • Author(s): Kim Y.S.
  • Journal Title: Proteomics 4 Pages: 3353-3358
• [Journal Article] Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransf erase III-transfected HeLaS3 cells. (2003)
  • Author(s): Shibukawa Y et al.
  • Journal Title: J Biol Chem 278 Pages: 3197-3203
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransf erase III within the golgi apparatus. (2003)
  • Author(s): Sasai K et al.
  • Journal Title: J Biol Chem 278 Pages: 25295-25301
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. (2003)
  • Author(s): Noda K et al.
  • Journal Title: Cancer Res 63 Pages: 6282-6289
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Purification and cDNA cloning of UDP-GlcNAc : GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine : a major carrier of dlGnT activity in rat small intestine. (2003)
  • Author(s): Korekane H et al.
  • Journal Title: Glycobiology 13 Pages: 387-400
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of alpha1, 6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid : its linkage to biological aggressiveness and anaplastic transformation. (2003)
  • Author(s): Ito Y et al.
  • Journal Title: Cancer Lett 200 Pages: 167-172
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Glycation proceeds faster in mutated Cu, Zn-superoxide dismutases related to familial amyotrophic lateral sclerosis. (2003)
  • Author(s): Takamiya R et al.
  • Journal Title: Faseb J 17 Pages: 938-940
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of the binding site of methylglyoxal on glutathione peroxidase : methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185. (2003)
  • Author(s): Park YS et al.
  • Journal Title: Free Radic Res 37 Pages: 205-211
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular cloning and characterization of human GnT-IX, a novel beta1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain. (2003)
  • Author(s): Inamori K et al.
  • Journal Title: J Biol Chem 278 Pages: 43102-43109
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differences in recognition of sulfated and sialylated carbohydrate chains. (2003)
  • Author(s): Honke K et al.
  • Journal Title: Methods Enzymol 363 Pages: 222-229
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Carbohydrate binding・activity of annexin V toward a bisecting N-acetylglucosamine. (2003)
  • Author(s): Gao CX et al.
  • Journal Title: Methods Enzymol 363 Pages: 34-47
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvement of oligosaccharide changes in alpha5beta1 integrin in a cisplatin-resistant human squamous cell carcinoma cell (2003)
  • Author(s): Nakahara S et al.
  • Journal Title: Mol Cancer Ther 2 Pages: 1207-1214
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells. (2003)
  • Author(s): Shibukawa, Y., Takahashi, M., Laffont, I., Honke, K.., Taniguchi, N.
  • Journal Title: J Biol Chem 278 Pages: 3197-3203
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus. (2003)
  • Author(s): Sasai, K., Ikeda, Y., Ihara, H., Honke, K., Taniguchi, N.
  • Journal Title: J Biol Chem 278 Pages: 25295-25301
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. (2003)
  • Author(s): Noda, K., Miyoshi, E., Gu, J., Gao, C.X., Nakahara, S., Kitada, T., Honke, K., Suzuki, K., Yoshihara, H., Yoshikawa, K., Kawano, K., Tonetti, M., Kasahara, A., Hori, M., Hayashi, N., Taniguchi, N.
  • Journal Title: Cancer Res 63 Pages: 6282-6289
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Purification and cDNA cloning of UDP-GlcNAc : GlcNAcbetal-3Galbetal-4Glc(NAc)-R [GlcNAc to Gal]betal,6N-acetylglucosaminyltransferase from rat small intestine : a major carrier of dIGnT activity in rat small intestine. (2003)
  • Author(s): Korekane, H., Taguchi, T., Sakamoto, Y., Honke, K., Dohmae, N., Salminen, H., Toivonen, S., Helin, J., Takio, K., Renkonen, 0., Taniguchi, N.
  • Journal Title: Glycobiology 13 Pages: 387-400
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of alphal,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid : its linkage to biological aggressiveness and anaplastic transformation. (2003)
  • Author(s): Ito, Y., Miyauchi, A., Yoshida, H., Uruno, T., Nakano, K., Takamura, Y., Miya, A., Kobayashi, K., Yokozawa, T., Matsuzuka, F., Taniguchi, N., Matsuura, N., Kuma, K.., Miyoshi, E.
  • Journal Title: Cancer Lett 200 Pages: 167-172
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glycation proceeds faster in mutated Cu, Zn-superoxide dismutases related to familial amyotrophic lateral sclerosis. (2003)
  • Author(s): Takamiya, R., Takahashi, M., Myint, T., Park, Y.S., Miyazawa, N., Endo, T., Fujiwara, N., Sakiyama, H., Misonou, Y., Miyamoto, Y., Fujii, J., Taniguchi, N.
  • Journal Title: Faseb J 17 Pages: 938-940
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of the binding site of methylglyoxal on glutathione peroxidase : methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185. (2003)
  • Author(s): Park, Y.S., Koh, Y.H., Takahashi, M., Miyamoto, Y., Suzuki, K., Dohmae, N., Takio, K., Honke, K.., Taniguchi, N.
  • Journal Title: Free Radic Res 37 Pages: 205-211
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular cloning and characterization of human GnT-IX, a novel betal,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain. (2003)
  • Author(s): Inamori, K., Endo, T., Ide, Y., Fujii, S., Gu, J., Honke, K.., Taniguchi, N.
  • Journal Title: J Biol Chem 278 Pages: 43102-43109
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differences in recognition of sulfated and sialylated carbohydrate chains. (2003)
  • Author(s): Honke, K., Ikeda, N., Taniguchi, N.
  • Journal Title: Methods Enzymol 363 Pages: 222-229
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Carbohydrate binding activity of annexin V toward a bisecting N-acetylglucosamine. (2003)
  • Author(s): Gao, C.X., Honke, K.., Taniguchi, N.
  • Journal Title: Methods Enzymol 363 Pages: 34-47
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of oligosaccharide changes in alpha5betal integrin in a cisplatin-resistant human squamous cell carcinoma cell line. (2003)
  • Author(s): Nakahara, S., Miyoshi, E., Noda, K., Ihara, S., Gu, J., Honke, K., Inohara, H., Kubo, T., Taniguchi, N.
  • Journal Title: Mol Cancer Ther 2 Pages: 1207-1214
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Plasma 3-deoxyglucosone elevation in chronic renal failure is associated with increased aldose reductase in erythrocytes. (2002)
  • Author(s): Hasuike Y et al.
  • Journal Title: Am J Kidney Dis 40 Pages: 464-471
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An enzymatic method of analysis for GDP-L-fucose in biological samples, involving high-performance liquid chromatography. (2002)
  • Author(s): Noda K et al.
  • Journal Title: Anal Biochem 310 Pages: 100-106
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A catalytically inactive beta 1, 4-N-acetylglucosaminyltransferase III (gnT-III) behaves as a dominant negative GnT-III inhibitor. (2002)
  • Author(s): Ihara H et al.
  • Journal Title: Eur J Biochem 269 Pages: 193-201
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The action of N-acetylglucosaminyltransferase-V is prevented by the bisecting GlcNAc residue at the catalytic step. (2002)
  • Author(s): Sasai K et al.
  • Journal Title: FEBS Lett 522 Pages: 151-155
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitrosamine (DEN) : identification of haptoglobin as a target molecule of GnT-III. (2002)
  • Author(s): Ekuni A et al.
  • Journal Title: Free Radic Res 36 Pages: 827-833
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] UDP-GlcNAc concentration is an important factor in the biosynthesis of beta1, 6-branched oligosaccharides : regulation based on the kinetic properties of N-acetylglucosaminyltransferase V. (2002)
  • Author(s): Sasai K et al.
  • Journal Title: Glycobiology 12 Pages: 119-127
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative damage due to copper ion and hydrogen peroxide induces GlcNAc-specific cleavage of an Asn-linked oligosaccharide. (2002)
  • Author(s): Eguchi H et al.
  • Journal Title: J Biochem (Tokyo) 131 Pages: 477-484
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The possibility of reducing xenoantigen levels with a novel gal 3'-sulfotransferase (GP3ST). (2002)
  • Author(s): Koma M et al.
  • Journal Title: J Biochem (Tokyo) 131 Pages: 517-522
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Paranodal junction formation and spermatogenesis require sulfoglycolipids. (2002)
  • Author(s): Honke K et al.
  • Journal Title: Proc Nati Acad Sci U S A 99 Pages: 4227-4232
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation : a novel function of GnT-V distinct from the original glycosyltransferase activity. (2002)
  • Author(s): Saito T et al.
  • Journal Title: J Biol Chem 277 Pages: 17002-17008
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. (2002)
  • Author(s): Ihara S et al.
  • Journal Title: J Biol Chem 277 Pages: 16960-16967
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Sulfotransferases and sulfated oligosaccharides. (2002)
  • Author(s): Honke K et al.
  • Journal Title: Med Res Rev 22 Pages: 637-654
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The enzymatic basis for the conversion of nonfucosylated to fucosylated alpha-fetoprotein by acyclic retinoid treatment in human hepatoma cells : activation of alpha 1-6 fucosyltransferase. (2002)
  • Author(s): Noda K et al.
  • Journal Title: Tumour Biol 23 Pages: 202-211
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats : possible involvement in expression of heparin-binding epidermal 9「owth factor-like 9rowth factor. (2002)
  • Author(s): Sakuda S et al.
  • Journal Title: J Hepatol 36 Pages: 527-533
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Plasma 3-deoxyglucosone elevation in chronic renal failure is associated with increased aldose reductase in erythrocytes. (2002)
  • Author(s): Hasuike, Y., Nakanishi, T., Otaki, Y., Nanami, M., Tanimoto, T., Taniguchi, N., Takamitsu, Y.
  • Journal Title: Am J Kidney Dis 40 Pages: 464-471
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An enzymatic method of analysis for GDP-L-fucose in biological samples, involving high-performance liquid chromatography. (2002)
  • Author(s): Noda, K., Miyoshi, E., Nakahara, S., Ihara, H., Gao, C.X., Honke, K., Yanagidani, S., Sasaki, Y., Kasahara, A., Hori, M., Hayashi, N., Taniguchi, N.
  • Journal Title: Anal Biochem 310 Pages: 100-106
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A catalytically inactive beta 1,4-N-acetylglucosaminyltransferase III (GnT-III) behaves as a dominant negative GnT-III inhibitor. (2002)
  • Author(s): Ihara, H., Ikeda, Y., Koyota, S., Endo, T., Honke, K.., Taniguchi, N.
  • Journal Title: Eur J Biochem 269 Pages: 193-201
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The action of N-acetylglucosaminyltransferase-V is prevented by the bisecting GlcNAc residue at the catalytic step. (2002)
  • Author(s): Sasai, K., Ikeda, Y., Eguchi, H., Tsuda, T., Honke, K.., Taniguchi, N.
  • Journal Title: FEBS Lett 522 Pages: 151-155
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitrosamine (DEN) : identification of haptoglobin as a target molecule of GnT-III. (2002)
  • Author(s): Ekuni, A., Miyoshi, E., Ko, J.H., Noda, K., Kitada, T., Ihara, S., Endo, T., Hino, A., Honke, K.., Taniguchi, N.
  • Journal Title: Free Radic Res 36 Pages: 827-833
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] UDP-GlcNAc concentration is an important factor in the biosynthesis of betal,6-branched oligosaccharides : regulation based on the kinetic properties of N-acetylglucosaminyltransferase V. (2002)
  • Author(s): Sasai, K., Ikeda, Y., Fujii, T., Tsuda, T., Taniguchi, N.
  • Journal Title: Glycobiology 12 Pages: 119-127
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative damage due to copper ion and hydrogen peroxide induces GlcNAc-specific cleavage of an Asn-linked oligosaccharide. (2002)
  • Author(s): Eguchi, H., Ikeda, Y., Koyota, S., Honke, K., Suzuki, K., Gutteridge, J.M., Taniguchi, N.
  • Journal Title: J Biochem (Tokyo) 131 Pages: 477-484
  • NAID: 10010646855
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The possibility of reducing xenoantigen levels with a novel gal 3'-sulfotransferase (GP3ST). (2002)
  • Author(s): Koma, M., Miyagawa, S., Honke, K., Nakai, R., Miyoshi, S., Ohta, M., Matsuda, H., Shirakura, R., Taniguchi, N.
  • Journal Title: J Biochem (Tokyo) 131 Pages: 517-522
  • NAID: 10010647099
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Paranodal junction formation and spermatogenesis require sulfoglycolipids. (2002)
  • Author(s): Honke, K., Hirahara, Y., Dupree, J., Suzuki, K., Popko, B., Fukushima, K., Fukushima, J., Nagasawa, T., Yoshida, N., Wada, Y., Taniguchi, N.
  • Journal Title: Proc Natl Acad Sci US A 99 Pages: 4227-4232
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation : a novel function of GnT-V distinct from the original glycosyltransferase activity. (2002)
  • Author(s): Saito, T., Miyoshi, E., Sasai, K., Nakano, N., Eguchi, H., Honke, K.., Taniguchi, N.
  • Journal Title: J Biol Chem 277 Pages: 17002-17008
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. (2002)
  • Author(s): Ihara, S., Miyoshi, E., Ko, J.H., Murata, K., Nakahara, S., Honke, K., Dickson, R.B., Lin, C.Y., Taniguchi, N.
  • Journal Title: J Biol Chem 277 Pages: 16960-16967
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sulfotransferases and sulfated oligosaccharides. (2002)
  • Author(s): Honke, K.., Taniguchi, N.
  • Journal Title: Med Res Rev 22 Pages: 637-654
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The enzymatic basis for the conversion of nonfucosylated to fucosylated alpha-fetoprotein by acyclic retinoid treatment in human hepatoma cells : activation of alphal-6 fucosyltransferase. (2002)
  • Author(s): Noda, K., Miyoshi, E., Kitada, T., Nakahara, S., Gao, C.X., Honke, K., Shiratori, Y., Moriwaki, H., Sasaki, Y., Kasahara, A., Hori, M., Hayashi, N., Taniguchi, N.
  • Journal Title: Tumour Biol 23 Pages: 202-211
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats : possible involvement in expression of heparin-binding epidermal growth factor-like growth factor. (2002)
  • Author(s): Sakuda, S., Tamura, S., Yamada, A., Miyagawa, J., Yamamoto, K., Kiso, S., Ito, N., Higashiyama, S., Taniguchi, N., Kawata, S., Matsuzawa, Y.
  • Journal Title: J Hepatol 36 Pages: 527-533
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis. (2001)
  • Author(s): Sakata N et al.
  • Journal Title: Cardiovasc Res 49 Pages: 466-475
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fusion hybrids with macrophage and melanoma ceils up-regulate N-acetylglucosaminyltransferase V, beta1-6 branching, and metastasis. (2001)
  • Author(s): Chakraborty AK et al.
  • Journal Title: Cell Growth Differ 12 Pages: 623-630
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ectopic expression of alpha1,6 fucosyltransferase in mice causes steatosis in the liver and kidney accompanied by a modification of lysosomal acid lipase. (2001)
  • Author(s): Wang W et al.
  • Journal Title: Glycobiology 11 Pages: 165-174
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Elevated expression of UDP-N-acetylglucosamine : alphamannoside beta1,6 N-acetylglucosaminyltransferase is an early event in hepatocarcinogenesis. (2001)
  • Author(s): Ito Y et al.
  • Journal Title: Int J Cancer 91 Pages: 631-637
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The critical role of the stem region as a functional domain responsible for the oligomerization and Golgi localization of N-acetylglucosaminyltransferase V. The involvement of a domain homophilic interaction. (2001)
  • Author(s): Sasai K et al.
  • Journal Title: J Biol Chem 276 Pages: 759-765
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin. (2001)
  • Author(s): Kitada T et al.
  • Journal Title: J Biol Chem 276 Pages: 475-480
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta l-3/1-4GlcNAc-R) oligosaccharides. (2001)
  • Author(s): Honke K et al.
  • Journal Title: J Biol Chem 276 Pages: 267-274
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Overexpression of N-acetylglucosaminyltransferase 111 enhances the epidermal 9rowth factor-induced phosphorylation of ERK in HeLaS3 cells by up-regulation of the internalization rate of the receptors. (2001)
  • Author(s): Sato Y et al.
  • Journal Title: J Biol Chem 276 Pages: 11956-11962
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta 1. (2001)
  • Author(s): Saito T et al.
  • Journal Title: J Biol Chem 276 Pages: 11469-11472
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Down-regulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase 111 gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc. (2001)
  • Author(s): Koyota S et al.
  • Journal Title: J Biol Chem 276 Pages: 32867-32874
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Remodeling of the major pig xenoantigen by N-acetyl glue OS aminyltransfe rase 111 in transgenic pig. (2001)
  • Author(s): Miyagawa S et al.
  • Journal Title: J Biol Chem 276 Pages: 39310-39319
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Increased protein glycation in cerebrospinal fluid of Alzheimer's disease. (2001)
  • Author(s): Shuvaev VV et al.
  • Journal Title: Neurobiol Aging 22 Pages: 397-402
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A glycomic approach to the identification and characterization of glycoprotein function in cells transfected with glycosyltransferase genes. (2001)
  • Author(s): Taniguchi N et al.
  • Journal Title: Proteomics 1 Pages: 239-247
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transgenic pigs with human N-acetylglucosaminyltransferase 111. (2001)
  • Author(s): Miyagawa S et al.
  • Journal Title: Transplant Proc 33 Pages: 742-743
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes. (2001)
  • Author(s): Ikeda N et al.
  • Journal Title: J Biol Chem 276 Pages: 38588-38594
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Down-regulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetyiglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc. (2001)
  • Author(s): Koyota S et al.
  • Journal Title: J Biol Chem 276 Pages: 32867-32874
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells. (2001)
  • Author(s): Koh YH et al.
  • Journal Title: J Biochem (Tokyo) 130 Pages: 351-358
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis. (2001)
  • Author(s): Sakata, N., Uesugi, N., Takebayashi, S., Nagai, R., Jono, T., Horiuchi, S., Takeya, M., Itabe, H., Takano, T., Myint, T., Taniguchi, N.
  • Journal Title: Cardiovasc Res 49 Pages: 466-475
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fusion hybrids with macrophage and melanoma cells up-regulate N-acetylglucosaminyltransferase V, betal-6 branching, and metastasis. (2001)
  • Author(s): Chakraborty, A.K., Pawelek, J., Ikeda, Y., Miyoshi, E., Kolesnikova, N., Funasaka, Y., Ichihashi, M., Taniguchi, N.
  • Journal Title: Cell Growth Differ 12 Pages: 623-630
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ectopic expression of alphal,6 fucosyltransferase in mice causes steatosis in the liver and kidney accompanied by a modification of lysosomal acid lipase. (2001)
  • Author(s): Wang, W., Li, W., Ikeda, Y., Miyagawa, J.I., Taniguchi, M., Miyoshi, E., Sheng, Y., Ekuni, A., Ko, J.H., Yamamoto, Y., Sugimoto, T., Yamashita, S., Matsuzawa, Y., Grabowski, G.A., Honke, K., Taniguchi, N
  • Journal Title: Glycobiology 11 Pages: 165-174
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elevated expression of UDP-N-acetylglucosamine : alphamannoside beta 1,6 N-acetylglucosaminyltransferase is an early event in hepatocarcinogenesis. (2001)
  • Author(s): Ito, Y., Miyoshi, E., Sakon, M., Takeda, T., Noda, K., Tsujimoto, M., Ito, S., Honda, H., Takemura, F., Wakasa, K., Monden, M., Matsuura, N., Taniguchi, N.
  • Journal Title: Int J Cancer 91 Pages: 631-637
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The critical role of the stem region as a functional domain responsible for the oligomerization and Golgi localization of N-acetylglucosaminyltransferase V. The involvement of a domain homophilic interaction. (2001)
  • Author(s): Sasai, K., Ikeda, Y., Tsuda, T., Ihara, H., Korekane, H., Shiota, K., Taniguchi, N.
  • Journal Title: J Biol Chem 276 Pages: 759-765
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin. (2001)
  • Author(s): Kitada, T., Miyoshi, E., Noda, K., Higashiyama, S., Ihara, H., Matsuura, N., Hayashi, N., Kawata, S., Matsuzawa, Y., Taniguchi, N.
  • Journal Title: J Biol Chem 276 Pages: 475-480
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides. (2001)
  • Author(s): Honke, K., Tsuda, M., Koyota, S., Wada, Y., Iida-Tanaka, N., Ishizuka, I., Nakayama, J., Taniguchi, N.
  • Journal Title: J Biol Chem 276 Pages: 267-274
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Overexpression of N-acetylglucosaminyltransferase III enhances the epidermal growth factor-induced phosphorylation of ERK in HeLaS3 cells by up-regulation of the internalization rate of the receptors. (2001)
  • Author(s): Sato, Y., Takahashi, M., Shibukawa, Y., Jain, S.K., Hamaoka, R., Miyagawa, J., Yaginuma, Y., Honke, K., Ishikawa, M., Taniguchi, N.
  • Journal Title: J Biol Chem 276 Pages: 11956-11962
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta 1. (2001)
  • Author(s): Saito, T., Kinoshita, A., Yoshiura, K., Makita, Y., Wakui, K., Honke, K., Niikawa, N., Taniguchi, N.
  • Journal Title: J Biol Chem 276 Pages: 11469-11472
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Down-regulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc. (2001)
  • Author(s): Koyota, S., Ikeda, Y., Miyagawa, S., Ihara, H., Koma, M., Honke, K., Shirakura, R., Taniguchi, N.
  • Journal Title: J Biol Chem 276 Pages: 32867-32874
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Remodeling of the major pig xenoantigen by N-acetylglucosaminyltransferase III in transgenic pig. (2001)
  • Author(s): Miyagawa, S., Murakami, H., Takahagi, Y., Nakai, R., Yamada, M., Murase, A., Koyota, S., Koma, M., Matsunami, K., Fukuta, D., Fujimura, T., Shigehisa, T., Okabe, M., Nagashima, H., Shirakura, R., Taniguchi, N.
  • Journal Title: J Biol Chem 276 Pages: 39310-39319
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Increased protein glycation in cerebrospinal fluid of Alzheimer's disease. (2001)
  • Author(s): Shuvaev, V.V., Laffont, I., Serot, J.M., Fujii, J., Taniguchi, N., Siest, G.
  • Journal Title: Neurobiol Aging 22 Pages: 397-402
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A glycomic approach to the identification and characterization of glycoprotein function in cells transfected with glycosyltransferase genes. (2001)
  • Author(s): Taniguchi, N., Ekuni, A., Ko, J.H., Miyoshi, E., Ikeda, Y., Ihara, Y., Nishikawa, A., Honke, K.., Takahashi, M.
  • Journal Title: Proteomics 1 Pages: 239-247
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transgenic pigs with human N-acetylglucosaminyltransferase III. (2001)
  • Author(s): Miyagawa, S., Murakami, H., Murase, A., Nakai, R., Koma, M., Koyota, S., Matsunami, K., Takahagi, Y., Fujimura, T., Shigehisa, T., Nagashima, H., Shirakura, R., Taniguchi, N.
  • Journal Title: Transplant Proc 33 Pages: 742-743
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes. (2001)
  • Author(s): Ikeda, N., Eguchi, H., Nishihara, S., Narimatsu, H., Kannagi, R, Irimura, T., Ohta, M., Matsuda, H., Taniguchi, N., Honke, K.
  • Journal Title: J Biol Chem 276 Pages: 38588-38594
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells. (2001)
  • Author(s): Koh, Y.H., Che, W., Higashiyama, S., Takahashi, M., Miyamoto, Y., Suzuki, K.., Taniguchi, N.
  • Journal Title: J Biochem (Tokyo) 130 Pages: 351-358
  • NAID: 10007858316
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Production of a recombinant single-chain variable-fragment (scFv) antibody against sulfoglycolipid (2000)
  • Author(s): Xinyao Cheng
  • Journal Title: J Biochem (Tokyo) 137 Pages: 415-421
• [Journal Article] Testis-Specific Sulfoglycolipid, Seminolipid Is Essential for Germ Cell Function in Spermatogenesis.
  • Author(s): Zhang Y
  • Journal Title: Glycobiology (In press)
• [Book] 糖鎖科学の新展開 (2005)
  • Author(s): 谷口直之, 伊藤幸成
  • Total Pages: 556
  • Publisher: NTS
• [Patent(Industrial Property Rights)] ゲノムが改変された非ヒ卜動物またはその子孫 (2006)
  • Inventor(s): 谷口直之, 顧 建国, 三善英知, 佐藤光男, 大貫尚子, 西谷春江
  • Industrial Property Rights Holder: 協和発酵株式会社
  • Industrial Property Number: 2006-040863
  • Filing Date: 2006
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] α-1.6-フコシルトランスフェラーゼ変異体とその用途 (2006)
  • Inventor(s): 谷口直之, 顧 建国, 三善英知, 佐藤光男, 大貫尚子, 中野了輔, 西谷春江
  • Industrial Property Rights Holder: 協和発酵株式会社
  • Industrial Property Number: 2006-052077
  • Filing Date: 2006
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] α 1-6フコシル化特異的レクチン (2005)
  • Inventor(s): 秦 洋二, 谷口直之, 三善英知, 顧 建国, 山本憲二
  • Industrial Property Rights Holder: 月桂冠株式会社
  • Industrial Property Number: 2005-358545
  • Filing Date: 2005-12-13
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] α1-6フコシル化糖特異的レクチン (2005)
  • Inventor(s): 秦 洋二
  • Industrial Property Rights Holder: 月桂冠
  • Industrial Property Number: 2005-358545
  • Filing Date: 2005-12-13
• [Patent(Industrial Property Rights)] Nアセチルグルコサミン転移酵素Vの合成基質及び酵素活性測定法 (2004)
  • Inventor(s): 佐治英郎, 向 高弘, 間賀田泰寛, 野出學, 加藤孝博, 谷口直之, 三善英知
  • Industrial Property Rights Holder: 日本メジフイジックス
  • Filing Date: 2004-03-18
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] α(1- 6)フコシルトランスフェラーゼの結晶 (2004)
  • Inventor(s): 谷口 直之, 井原 秀之
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Filing Date: 2004-01-19
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 金属錯化合物抗癌剤に対する癌細胞の耐性の検査方法及び該耐性を低減さ せるための薬剤 (2003)
  • Inventor(s): 谷口直之, 三善英知, 中原 晋
  • Industrial Property Rights Holder: JGS
  • Industrial Property Number: 2003-046918
  • Filing Date: 2003-02-25
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 血管新生作用を有する糖転移酵素GnT-V (2002)
  • Inventor(s): 谷口直之, 三善英知, 斉藤貴志
  • Industrial Property Rights Holder: サントリー
  • Industrial Property Number: 2002-002056
  • Filing Date: 2002-01-09
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] GDP-L-フコースの定量方法及びGDP-L-フコース量を測定して癌の診断に用いる方法 (2002)
  • Inventor(s): 谷口直之, 三善英知, 野田勝久
  • Industrial Property Rights Holder: JGS
  • Industrial Property Number: 2002-234156
  • Filing Date: 2002-08-09
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 血管新生作用を有する糖転移酵素GnT-V (2002)
  • Inventor(s): 谷口直之, 三善英知, 斉藤貴志
  • Industrial Property Rights Holder: サントリー
  • Filing Date: 2002-01-09
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Shibukawa, Y. et al.: "Down-regulation of hydrogen peroxide-induced PKCδ activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells"J.Biol.Chem.. 278. 3197-3203 (2003)
• [Publications] Inamori, K. et al.: "Molecular cloning and characterization of human GnT-IX, a novel β1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain"J.Biol.Chem.. 278. 43102-43109 (2003)
• [Publications] Inamori, K. et al.: "N-acetylglucosaminyltransferase IX acts on the GlcNAcβ1,2-Manα1-Ser/Thr moiety, forming a 2,6-branched structure in brain 0-mannosyl glycan"J.Biol.Chem.. 279. 2337-2340 (2004)
• [Publications] Noda, K. et al.: "Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines"Cancer Res.. 63. 6282-6289 (2003)
• [Publications] Gu, J.et al.: "β1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells"Glycobiology. 14. 177-186 (2004)
• [Publications] Ihara, S. et al.: "Addition of β1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin"Glycobiology. 14. 139-146 (2004)
• [Publications] Isaji, T. et al.: "Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration"J.Biol.Chem.. 279(in press). (2004)
• [Publications] Taniguchi, N. et al.: "Functional glycomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis : their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer"Proc.Japan Acad. 80(in press). (2004)
• [Publications] Saito, T., et al.: "A secreted type of β1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation"J. Biol. Chem.. 277. 17002-17008 (2002)
• [Publications] Ihara, S., et al.: "Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding β1-6 GIcNAc branching"J. Biol. Chem.. 277. 16960-16967 (2002)
• [Publications] Honke, K., et al.: "Paranodal junction formation and spermatogenesis require sulfoglycolipids"Proc. Natl. Acad. Sci. U.S.A.. 99. 4227-4232 (2002)
• [Publications] Shibukawa, Y., et al.: "Down-regulation of hydrogen peroxide-induced PKCδ activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells"J. Biol. Chem.. 278. 3197-3203 (2003)
• [Publications] Ihara, H., et al.: "A catalytically inactive beta 1,4-N-acetylglucosaminyltransferase III (GnT-III) behaves as a dominant negative GnT-III inhibitor"Eur. J. Biochem.. 269. 193-201 (2002)
• [Publications] Sasai, K., et al.: "UDP-GIcNAc concentration is an important factor in the biosynthesis of β1,6-branched oligosaccharides : regulation based on the kinetic properties of N-acetylglucosaminyltransferase V"Glycobiology. 12. 119-127 (2002)
• [Publications] K.Sasai, Y.Ikeda, N.Taniguchi et al.: "The critical role the stem region as a functional domain responsibe for the oligomerization and Golgi localization of N-acetylglucosaminyltransferase V : The involvement of a domain homophilic interacion"J. Biol. Chem.. 276. 759-765 (2001)
• [Publications] T.Kitada, E.Miyoshi, N.Taniguchi et al.: "The addition of bisecting N-acetylglucosamine residues to E-cadherin downregulates the tyrosine phosphorylation of beta-catenin"J. Biol. Chem.. 276. 475-480 (2001)
• [Publications] K.Honke, N.Taniguchi et al.: "Molecular cloning and characterization of a Human b-Gal 3'-Sulfotransferase which acts on both type 1 and type 2 (Galb, 3/4, GlcNAc-R) oligosaccharides"J. Biol. Chem.. 276. 267-274 (2001)
• [Publications] Y.Sato, M.Takahashi, K.Honke, N.Taniguchi et al.: "Overexpression of N-acetylglucosaminyltransferase III enhances the EGF-induced phosphorylation of ERK in HeLaS3 cells by upregulation of the internalization rate of the receptors"J. Biol. Chem.. 276. 11956-11962 (2001)
• [Publications] W.Wang, Y.Ikeda, E.Miyoshi, K.Honke, N.Taniguchi et al.: "Ectopic expression of α1,6 fucosyltransferase in mice causes steatosis in the liver and kidney accompanied by a modification of lysosomal acid lipase"G, lycobiology. 11. 165-174 (2001)
• [Publications] N.Taniguchi, E.Miyoshi, Y.Ikeda, K.Honke, et al.: "A glycomic approach to the identification and characterization of glycoprotein function in cells transfected with glycosyltransferase genes"Proteomics. 1. 239-247 (2001)
• [Publications] T.Saito, K.Honke, N.Taniguchi et al.: "Domain-specific Mutations of a Transforming Growth Factor(TGF)-bl Latency-associated Peptide Cause Camurati-Engelmann Disease Because of the Formation of a Constitutively Active Form of TGH-bl"J. Biol. Chem.. 276. 11469-11472 (2001)
• [Publications] S.Koyota, Y.Ikeda, K.Honke, N.Taniguchi et al.: "Down-regulation of the alpha-Gal Epitope Expression in N-Glycans of Swine Endothelial Cells by Transfection with the N-Acetylglucosaminyltransferase III Gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc"J. Biol. Chem.. 276. 32867-32874 (2001)
• [Publications] S.Miyagawa, N.Taniguchi et al.: "Remodeling of the major pig xenoantigen by N-acetylglucosaminyltransferase III in transgenic pig"J. Biol. Chem.. 276. 39310-39319 (2001)
• [Publications] A.K.Chakraborty, E.Miyoshi, Y.Ikeda, N.Taniguchi et al.: "Fusion Hybrids with Macrophage and Melanoma Cells Up-Regulate N-Acetylglucosaminyltransferase V, β1-6 Branching, and Metastasis"Cell Growth Differ.. 12. 623-630 (2001)
• [Publications] Y.Ito, E.Miyoshi, N.Taniguchi et al.: "Elevated expression of UDP-N-acetylglucosamine : alphamannoside beta 1,6N-acetylglucosaminyltransferase is an early event in hepatocarcinogenesis"Int. J. Cancer. 91. 631-637 (2001)
• [Publications] H.Ihara, Y.Ikeda, K.Honke, N.Taniguchi et al.: "A catalytically inactive beta 1,4-N-acetylglucosaminyltransferase III (GnT-III) behaves as a dominant negative GnT-III inhibitor"Eur. J. Biochem.. 269. 193-201 (2001)
• [Publications] A.Ekumi, E.Miyoshi, K.Honke, N.Taniguchi et al.: "A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III(GnT-III) transgenic mice induced by diethylynitorsamine(DEN) : Identification of haptoglogin as a target molecule of GnT-III"Free Rad. Res.. (in press). (2002)
• [Publications] S.Ihara, E.Miyoshi, K.Honke, N.Taniguchi et al.: "Pro-metastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding β1-6 GlcNAc-branching"J. Biol. Chem.. (in press). (2002)
• [Publications] T.Saito, E.Miyoshi, K.Honke, N.Taniguchi et al.: "A secreted type of β1, 6-N-acetylglucosaminyltransferase V(GnT-V)induces tumor angiogenesis without mediation of glyosylation; ---A novel function of GnT-V distinct from the original glycosyltransferase activiy---"J. Biol. Chem.. (in press). (2002)
• [Publications] N.Taniguchi, E.Miyoshi, Y.Ikeda et al.: "Glycans in Cell Interaction and Recognition Therapeutic Aspects"The involvement of bisecting N-Acetylglucosamine in cancer. 73-88 (2001)