自励振動ゲルを用いた新規化学システムの構築

Research Project

Project/Area Number	13F03038
Research Category	Grant-in-Aid for JSPS Fellows
Allocation Type	Single-year Grants
Section	外国
Research Field	Polymer/Textile materials
Research Institution	The University of Tokyo
Principal Investigator	吉田亮東京大学, 工学(系)研究科(研究院), 教授 (80256495)
Co-Investigator(Kenkyū-buntansha)	JIMENEZ Zulma 東京大学, 工学(系)研究科(研究院), 外国人特別研究員 JIMENEZ Z. A. 東京大学, 大学院工学系研究科, 外国人特別研究員
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥1,200,000 (Direct Cost: ¥1,200,000) Fiscal Year 2014: ¥600,000 (Direct Cost: ¥600,000) Fiscal Year 2013: ¥600,000 (Direct Cost: ¥600,000)
Keywords	高分子 / 機能性材料 / 相転移 / 自己集合 / 温度応答性高分子 / 化学振動反応 / N-イソプロピルアクリルアミド / サーモセンサー
Outline of Annual Research Achievements	We report a zwitterionic block copolymer composed of N-isopropylacrylamide and N,N-dimethyl-N-(3-(methacrylamido)propyl) ammoniopropane sulfonate monomers which self-assembles into different structures depending on the solution temperature. As the temperature is increased from 20 °C to 70 °C, the solubility of the polymer switches direction from insoluble to soluble to insoluble to soluble. During this process, the polymer self-assembly changes from polymersomes to micelles. These extraordinary transitions are possible because of the hydrophilic-hydrophobic ratio of the polymer blocks and the presence of a carbonyl group attached to the end of the poly(N-isopropyl acrylamide) chain. Additionally, one of these transitions can be controlled by the pH of the solution thanks to the protonation-deprotonation of the carbonyl and the charge neutralization of the ammonium moieties. The present work opens the possibility of designing polymers with temperature driven self-assembly properties that could be used for biomedical applications.
Research Progress Status	26年度が最終年度であるため、記入しない。
Strategy for Future Research Activity	26年度が最終年度であるため、記入しない。