異なるヘルパーＴ細胞による腸管ＩｇＡの変化と腸内細菌叢への影響の検討
| Project/Area Number |
13F03216
|
|---|
| Research Category |
Grant-in-Aid for JSPS Fellows
|
| Allocation Type | Single-year Grants |
|---|
| Section | 外国 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
ファガラサン シドニア 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (00391970)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Lucia 独立行政法人理化学研究所, 統合生命医科学研究センター, 外国人特別研究員
TAKAHASHI Lucia 独立行政法人理化学研究所, 統合生命医科学研究センター, 外国人特別研究員
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2014: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2013: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | IgA / Foxp3 / gut bacteria / Peyer's patches / germinal center |
|---|
| Outline of Annual Research Achievements |
The aim of the project was to dissect the contribution of the adaptive immune system in establishing the symbiosis between host and bacteria in the gut.
We found that: 1) mice deficient for B cells, T cells or both, fail to support complex bacterial communities in the gut; 2) the reconstitution of T cell-deficient mice with CD4+ T cells expressing the transcription factor Foxp3 (Foxp3+ T cells) restores both the diversity and the phylogenetic structure of bacteria; 3) Foxp3+ T cells helped diversification particularly of the non-virulent Clostridia species, which were recently reported to induce Foxp3. This means that not only Clostridia induce Foxp3, but that the Foxp3+ T cells contribute to the persistence and diversification of Clostridia of the Firmicutes (the most diverse bacterial species in both mice and humans); 4) Foxp3+ T cells act outside and inside germinal centers, by preventing inflammation and by regulating selection of IgAs, respectively; 5) the coating of bacteria with selected IgAs was required to maintain the bacteria in the gut and to prevent the expansion of opportunistic species which could become pathogenic.
The research was published in Immunity, 2014.
|
| Research Progress Status |
26年度が最終年度であるため、記入しない。
|
| Strategy for Future Research Activity |
26年度が最終年度であるため、記入しない。
|
Report
(2 results)
Research Products
(4 results)
-
-
[Journal Article] Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis2014
Author(s)
Shimpei Kawamoto, Mikako Maruya, Lucia M. Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, and Sidonia Fagarasan
-
Journal Title
Immunity
Volume: 41
Issue: 1
Pages: 152-165
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
